Low rumen degradable starch promotes the growth performance of goats by increasing protein synthesis in skeletal muscle via the AMPK-mTOR pathway

Liang, Ziqi; Jin, Chunjia; Bai, Hanxun; Liang, Guozheng; Su, Xiaodong; Wang, Dangdang; Yao, Junhu

doi:10.1016/j.aninu.2022.10.006

Cited by 6 publications

(3 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MAPK signaling pathway plays an important role in complex cellular processes, such as proliferation, differentiation, and survival. While the activation of the MAPK signaling pathway is associated with the differentiation ability of various stem cells [ 17 ], two main types of MAPK pathways include p38 MAPK and ERK1/2 [ 29 ]. Among them, p38 MAPK pathway mainly controls satellite cells, which is closely related to cell cycle.…”

Section: Discussionmentioning

confidence: 99%

Zein-Derived Peptides from Corn Promote the Proliferation of C2C12 Myoblasts via Crosstalk of mTORC1 and mTORC2 Signaling Pathways

Amin,

Yu,

et al. 2024

Foods

View full text Add to dashboard Cite

Dietary protein supplementation has emerged as a promising strategy in combating sarcopenia. Furthermore, searching for alternatives of animal proteins has been a hot topic. The present study aimed to investigate the effects of zein peptides on C2C12 myoblasts and explore their potential molecular mechanisms. The proliferative, cell cycle, and anti-apoptotic activities of zein peptides were evaluated. Peptidomics analysis and transcriptome sequencing were employed to explore the structure-activity relationship and underlying molecular mechanisms. The results indicated that zein peptides (0.05–0.2 mg/mL) exerted a significant proliferation-promoting impact on C2C12 cells, via increasing cell viability by 33.37 to 42.39%. Furthermore, zein peptides significantly increased S phase proportion and decreased the apoptosis rate from 34.08% (model group) to 28.96% in C2C12 cells. In addition, zein peptides exhibited a pronounced anti-apoptotic effect on C2C12 cells. Zein peptides are abundant in branch-chain amino acids, especially leucine. Transcriptomics analysis revealed that zein peptides can promote proliferation, accelerate cell cycle, and improve protein synthesis of muscle cells through mTORC1 and mTORC2 signaling pathways.

show abstract

Section: Discussionmentioning

confidence: 99%

Zein-Derived Peptides from Corn Promote the Proliferation of C2C12 Myoblasts via Crosstalk of mTORC1 and mTORC2 Signaling Pathways

Amin,

Yu,

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

“…It was demonstrated that CT attenuated tumor growth by activating the AMP-activated protein kinase (AMPK) signaling pathway. The activation of the AMPK signaling pathway leads to the suppression of mTOR activity, which is responsible for the inhibition of protein synthesis [ 17 , 18 ]. Altered aminoacyl-tRNA biosynthesis may cause oxidative stress, which may ultimately sabotage the cellular and metabolic activities of tumor cells [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Study on the Intervention Mechanism of Cryptotanshinone on Human A2780 Ovarian Cancer Cell Line Using GC-MS-Based Cellular Metabolomics

Wang

Yin

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

Cryptotanshinone (CT), an active component of the traditional Chinese medicine Salvia miltiorrhiza Bunge, exhibits a wide range of biological and pharmacological activities. Although the anticancer activity of CT is well known, the knowledge of its effect on the regulation of cancer cell metabolism is relatively new. The present study investigated the anticancer mechanism of CT in ovarian cancer with a focus on cancer metabolism. CCK8 assays, apoptosis assays, and cell cycle assays were conducted to reveal the growth-suppressive effect of CT on ovarian cancer A2780 cells. To explore the potential underlying mechanisms of CT, the changes in endogenous metabolites in A2780 cells before and after CT intervention were investigated using the gas chromatography–mass spectrometry (GC-MS) approach. A total of 28 important potential biomarkers underwent significant changes, mainly involving aminoacyl-tRNA biosynthesis, energy metabolism, and other pathways. Changes in the ATP and amino acid contents were verified with in vitro and in vivo experiments. Our results indicate that CT may exert an anti-ovarian cancer effect by inhibiting ATP production, promoting the protein catabolic process, and inhibiting protein synthesis, which may lead to cell cycle arrest and apoptosis.

show abstract

“…By examining and interpreting power grid data, artificial intelligence (AI) technology can enhance the intelligent management of power grids, thus reducing energy consumption and environmental pollution (Cai et al, 2022;Tang et al, 2022;Wu et al, 2023). The hybridcascaded high-voltage direct current (HVDC) transmission technique can effectively reduce power transmission losses, and a combination of the two can boost further the energy utilization efficiency and intelligence of the power grid (Tang et al, 2021;Dong et al, 2023;Liang et al, 2023). In China, the energy distribution is opposite with respect to the center, with bounteous renewable energy sources in the west and developed economies and highenergy demand in the east, and HVDC has numerous potential applications as an important means of large-scale energy transfer.…”

Section: Introductionmentioning

confidence: 99%

Study on the characteristic of the grounding fault on the cascaded midpoint side of the hybrid cascaded HVDC system

et al. 2023

View full text Add to dashboard Cite

The hybrid cascaded high-voltage direct current (HVDC) system combines the system support capabilities of the modular multilevel converter (MMC) with the capacity of the line-mutated converter’s (LCC’s) advantage of high-power transmission. The HVDC system is among the key elements of a smart grid where artificial intelligence is applied extensively. However, the characteristics of a grounding fault on the cascaded midpoint side of a hybrid cascaded HVDC system remain unclear. This study analyzes fault characteristics and the impact of faults using analytical methods. First, the topology and basic control strategy are presented. The fault response process is then analyzed by dividing systems into the MMC and LCC parts at the inverter side. A separate theoretical analysis is also conducted. In addition, the impacts of faults on HVDC and alternating current (AC) networks are analyzed. Therefore, even after the HVDC system is disabled, the AC network can supply fault currents using an antiparallel diode. The simulation results show that the proposed analysis method is feasible, and the theoretical analysis is correct. The proposed method can provide a theoretical basis for the selection of equipment for HVDC systems and smart grid construction.

show abstract

Low rumen degradable starch promotes the growth performance of goats by increasing protein synthesis in skeletal muscle via the AMPK-mTOR pathway

Cited by 6 publications

References 68 publications

Zein-Derived Peptides from Corn Promote the Proliferation of C2C12 Myoblasts via Crosstalk of mTORC1 and mTORC2 Signaling Pathways

Zein-Derived Peptides from Corn Promote the Proliferation of C2C12 Myoblasts via Crosstalk of mTORC1 and mTORC2 Signaling Pathways

Study on the Intervention Mechanism of Cryptotanshinone on Human A2780 Ovarian Cancer Cell Line Using GC-MS-Based Cellular Metabolomics

Study on the characteristic of the grounding fault on the cascaded midpoint side of the hybrid cascaded HVDC system

Contact Info

Product

Resources

About