Low risk of melanoma in patients with atopic dermatitis

Synnerstad, Ingrid; Fredrikson, Mats; Ternesten-Bratel, Annika; Rosdahl, Inger

doi:10.1111/j.1468-3083.2008.02888.x

Cited by 32 publications

(25 citation statements)

References 32 publications

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“…A very recent Danish cohort study [ 9 ], on more than 30,000 AD patients, also showed results in the same direction. [ 10 ], which was not the case in our cohort [ 6 ].…”

Section: Epidemiological Studiescontrasting

confidence: 67%

Atopic Dermatitis and Skin Cancer

2014

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Filaggrin gene ( FLG ) mutation carriage increases the risk of atopic dermatitis (AD), contact allergy, asthma, hay fever, and peanut allergy. These genetic variants also infl uence the severity of asthma and alopecia areata and susceptibility to herpetic infection [ 1 ]. Squamous cell carcinoma (SSC) in the skin is perhaps the most rapidly increasing malignancy arising through mutations in epidermal cells in sun-exposed areas. UVB radiation damages the DNA and its repair system and causes mutations in tumor-suppressing genes. The risk of metastasis increases if the mutated cells penetrate the dermis. Other risk factors for SCC include chronic sun exposure to UVB and UVA, a suppressed immune system due to treatment effects, exposure to cyclic aromatic hydrocarbons in tar, or long-standing infl ammation. Basal cell carcinoma (BCC) arises from basal keratinocytes in epidermis. In this kind of tumor, UVB is also important for the induction of damaging the DNA and its repair system and also causing mutations in tumor-suppressing genes. BCC grows by direct extension and almost never metastasizes. Malignant melanoma (MM) is a malignancy of melanocytes located mostly in the skin but also in the eyes, ears, central nervous system, and gastrointestinal (GI) tract. Malignant melanoma accounts for approximately 4 % of skin cancers but is responsible for more than 74 % skin cancer deaths [ 2 ]. The melanocyte transformation is poorly understood. It involves a series of steps, several unknown, with progressive genetic mutation that alters cell proliferation, differentiation, and death, and has an impact from

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“…A very recent Danish cohort study [ 9 ], on more than 30,000 AD patients, also showed results in the same direction. [ 10 ], which was not the case in our cohort [ 6 ].…”

Section: Epidemiological Studiescontrasting

confidence: 67%

Atopic Dermatitis and Skin Cancer

2014

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“…An association between cancer and allergy has been previously recognized [34]. The incidences of glioma, colorectal, larynx, esophageal, oral, pancreatic, stomach, and uterine cancers, as well as melanoma and non-Hodgkin's lymphoma, were found to be decreased in the allergic condition, whereas the incidences of bladder cancer, lymphoma, and myeloma, and prostate cancer were increased in the allergic condition [35], [36]. Case-control studies, multicenter case-control studies, and rigorous meta-analyses have provided stronger support for the relationship between allergy and cancer development [37], [38], [39], [40].…”

Section: Discussionmentioning

confidence: 91%

Activated Natural Killer Cells Mediate the Suppressive Effect of Interleukin-4 on Tumor Development via STAT6 Activation in an Atopic Condition Melanoma Model

et al. 2017

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A protective effect of allergy for cancer has been suggested, but the results are somewhat conflicting, and the mechanism remains elusive. Interleukin-4 (IL-4) signaling has been identified as a potentially important pathway in the development of allergies and the suppression of cancer development. To evaluate the allergy responses in IL-4–mediated tumor development, we compared the growth of B16F10 melanoma cells in 4% phthalic anhydride (PA)-treated IL-4/Luc/CNS-1 transgenic mice (IL-4 mice) and acetone-olive oil (AOO)–treated IL-4 mice as a control for 3 weeks. Much higher allergic responses and natural killer (NK) and STAT6 activation were found in PA-treated IL-4 mice compared with AOO-treated IL-4 control mice. Tumor volume and weight showed an inverse association with the higher allergic response and were significantly reduced in the PA-treated IL-4 mice when compared with those of AOO-treated IL-4 control mice. Significantly higher activation of STAT6, as well as IL-4 and NK cell activation, was found in the tumor tissues of PA-treated IL-4 mice. Infiltration of immune cells and cytokine levels were also higher in the tumor tissues of PA-treated IL-4 mice. We further found that IL-4–activated NK-92MI cells showed increased anticancer effects in human melanoma cells. Overall, these results showed that allergy responses further accelerated the IL-4–induced inhibition of tumor development through the activation of STAT6 pathways.

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“…Such alterations are likely to influence the risk of skin tumors. For instance, in psoriasis 12 and atopic dermatitis 13 it has been shown that subjects affected by these diseases have a reduced number of melanocytic nevi, suggesting that cytokine networks involved in such conditions might inhibit melanogenesis, melanocyte growth, and/or progression to nevi.…”

Section: Methodsmentioning

confidence: 99%