Markedly reduced incidence of melanoma and nonmelanoma skin cancer in a nonconcurrent cohort of 10,040 patients with vitiligo

Current Approach to Phototherapy Applications in Dermatology Practice: Part 2. Phototherapy in Vitiligo, Mycosis Fungoides, Atopic Dermatitis, Sclerosing Diseases and Psoriasis

“…Ancak, dar bant UVB'nin vitiligoda deri kanseri riskini artırdığına dair herhangi bir veri yoktur. Hatta, yapılan çeşitli çalışmalarda, vitiligoda deri kanseri riskinin düşük olduğu saptanmıştır (9,10). Yine de, tedavinin gereksiz uzatılmaması ve uzun süre fototerapi yapılan hastaların düzenli olarak izlenmesi konusuna önem verilmelidir.…”

Low frequency of skin cancers in vitiligo patients

“…It is assumed that the overexpression of the wild protein p53, which is responsible for apoptosis, present in keratinocytes of these patients, prevents photodamage of the skin and development of tumors of epidermal origin. Patients with vitiligo have increased levels of glutathione peroxidase and superoxide dismutase [28][29][30] and overproduction of interleukin (IL)-1 and tumor necrosis factor (TNF)-α, which play a role in the induction of superoxide dismutase. At the same time, there is a decrease of transforming growth factor (TGF)-β and IL-10, which may indicate reduced susceptibility to skin carcinogenesis [31,32].…”

“…An important function of glutathione peroxidase in protecting cells from oxidative damage was confirmed in a study of mice irradiated by UV. The UVR provoked a decrease of the enzyme level and this, in consequence, predisposed to formation of squamous cell carcinoma [29].…”

“…Incidence of malignant melanoma and nonmelanoma skin cancers in non-vitiligo patients Rycina 4. Częstość występowania czerniaka i nieczerniakowych nowotworów skóry u pacjentów bez vitiligo of developing skin cancer in patients with vitiligo despite increased exposure to UV radiation associated with frequently used phototherapy [29]. This may be related to the recommendation of the use of creams with a high SPF.…”

Cutaneous Field Cancerization on a Vitiligo Area

“…The oldest reports of a disease similar to Vitiligo known until today date from 1500 AC, present in sacred Hindu writings and in texts of ancient Egypt [1]. Classified as a disease of acquired character, in the most cases, with a prevalence of 0,5% all around the world [2], without predilection of gender, racial or age [3][4][5] although some studies reveal prevalence in females. Clinically, is expressed by patches and macules, achromic and rarely hypochromic, located mainly in the skin and mucous membranes, due to the decrease or absence of melanocytes, resulting from the autoantibodies produced by the own body that will eventually destroy them.…”