“…This is also the case for TMDs, which are gradually becoming more and more understandable in terms of classification, etiopathogenesis, and treatment [ 34 , 35 ], and in this field, new therapeutic methods are constantly searched for, including intra-articular injections [ 6 , 8 , 14 , 17 , 20 , 36 ]. As with any emerging therapy, clinicians face the risk of unexpected adverse events that may result in serious complications [ 37 , 38 , 39 , 40 , 41 ]. A more subtle issue is to assess the effectiveness of emerging treatments and see if they are any better than the existing ones [ 8 , 14 , 16 , 17 , 25 , 42 ].…”