Low pulmonary function is related with a high risk of sarcopenia in community-dwelling older adults: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011

Jeon, Yun Kyung; Shin, Myung Jun; Kim, M. H.; Mok, James; Kim, Sung Sik; Kim, B. H.; Kim, Y. K.; Chang, Jae Hyeok; Shin, Yong‐Il; Kim, I. J.

doi:10.1007/s00198-015-3152-8

Cited by 68 publications

(65 citation statements)

References 35 publications

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“…In this sense, in communitydwelling older adults, low FEV1 is associated with low muscle mass in both males and females, suggesting that impaired pulmonary function relates to low muscle mass (Jeon et al, 2015). Supporting this idea, sarcopenia was shown to be highly prevalent in COPD patients and associated with impaired strength (van de Bool et al, 2015).…”

Section: Chronic Respiratory Diseasesmentioning

confidence: 88%

Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults

Angulo

Assar

Rodríguez‐Mañas

2016

Molecular Aspects of Medicine

131

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Section: Chronic Respiratory Diseasesmentioning

confidence: 88%

Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults

Angulo

Assar

Rodríguez‐Mañas

2016

Molecular Aspects of Medicine

131

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“…These previous studies were conducted in older patients in hospitals and/or nursing homes, not in community‐dwelling subjects, and had mostly small sample sizes. Nevertheless, few studies have explored lung function in healthy subjects . Our survey is the first assessing pulmonary and physical function in a general and in a large sample of non‐selected population.…”

Section: Discussionmentioning

confidence: 99%

Relationship between pulmonary function and physical performance among community‐living people: results from Look‐up 7+ study

Landi

Salini

Zazzara

et al. 2019

J cachexia sarcopenia muscle

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Background While respiratory muscle strength is recognized to decline with aging process, the relationship between sarcopenia and pulmonary function remains to be studied. The present study was undertaken to provide a better insight into the comprehension of the relationship between pulmonary function and muscle function (strength and physical performance) using an unselected sample of subjects assessed during the Longevity Check‐up 7+ project. Methods Look‐up 7+ is an ongoing cross‐sectional survey started in June 2015 and conducted in unconventional settings (i.e. exhibitions, malls, and health promotion campaigns) across Italy. Candidate participants are eligible for enrolment if they are at least 18 years of age and provide written informed consent. Muscle strength was assessed by handgrip strength test, and physical performance was evaluated by chair stand test. Spirometer analysis was performed using the AirSmart system, and the largest forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and peak expiratory flow (PEF) values were collected. Results The mean age of 925 subjects participating in the Longevity check‐7+ surveys and receiving the spirometer evaluation was 55.6 years (range from 18 to 98 years), and 501 (54%) were women. Overall, both in male and female participants, FVC, FEV1 and PEF positively correlated with handgrip strength and chair stand tests. The receiver operator characteristic curve analysis revealed that the areas under the curves for FVC, FEV1, and PEF were 0.79, 0.80 and 0.80, respectively. Conclusions The results clearly show that pulmonary function was positively associated with handgrip strength and chair stand tests. Based on this observation, muscle strength, physical performance, and pulmonary function should be recommended as the method of choice for the early detection of individuals at risk of probable sarcopenia and at the same time to better characterized the severity of sarcopenia status.

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“…Mean BMI at both seasonal time points was within the overweight category (BMI 25.0–29.9 kg/m 2 ), which has been associated with poor vitamin D status in some studies,41,42 including COPD populations 43. Nonetheless, BMI cannot distinguish between fat mass (FM) and FFM, which is particularly important in COPD patients, who are at risk of sarcopenia22 or sarcopenic obesity (normal BMI but with low FFM and increased FM) 44. Despite no significant associations between body composition and 25(OH)D concentration it is encouraging that in a population with a chronic and progressive disease, such as COPD, there is no significant deterioration in FFM over ~6 months.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with moderate to severe COPD often present with muscle wastage and severe muscle weakness, which can manifest as cachexia or sarcopenia, both of which have been associated with increased mortality risk and disease severity 21,22. Cachexia in COPD patients is typically diagnosed through low body mass index (BMI ⩽18.5 kg/m 2 ) and a low fat-free mass index (FFMI),23 while sarcopenia can be defined as low FFM with a normal or elevated BMI 24.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D status is associated with muscle strength and quality of life in patients with COPD: a seasonal prospective observation study

Carson¹,

Pourshahidi²,

Madigan³

et al. 2018

COPD

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BackgroundOwing to hospitalization, reduced functional capacity and consequently, less sunlight exposure, suboptimal vitamin D status (25-hydroxyvitamin D [25(OH)D]⩽50 nmol/L) is prevalent among COPD patients.ObjectiveThis study aimed to investigate seasonal changes in vitamin D status and any associated changes in fat-free mass (FFM), muscle strength and quality of life (QoL) in COPD patients.Patients and methodsCOPD patients living in Northern Ireland (n=51) completed study visits at the end of winter (March/April) and at the end of summer (September/October), corresponding to the nadir and peak of vitamin D status, respectively. At both time points, serum concentration of 25(OH)D was quantified by liquid chromatography-tandem mass spectrometry, FFM (kg) was measured using bioelectrical impedance and muscle strength (kg) was measured using handgrip dynamometry. QoL was assessed using the validated St George’s Respiratory Questionnaire.ResultsMean±SD 25(OH)D concentration was significantly higher at the end of summer compared to the end of winter (52.5±30.5 nmol/L vs 33.7±28.4 nmol/L, P<0.001); and house- bound patients had significantly lower 25(OH)D concentration compared to nonhousebound patients at the end of summer (42.9±4.2 vs 57.2±9.9 nmol/L; P⩽0.001). Muscle strength (at both time points) and QoL (end of summer only) were positively predicted by 25(OH)D concentration, independent of age, sex and smoking status.ConclusionThis study highlights the need for health policies to include a recommendation for year-round vitamin D supplementation in housebound COPD patients, and wintertime supplementation in nonhousebound patients, to maintain optimal 25(OH)D concentrations to protect musculoskeletal health. Furthermore, an optimal vitamin D status may have potential benefits for QoL in these patients.

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Low pulmonary function is related with a high risk of sarcopenia in community-dwelling older adults: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011

Abstract: Using nationally representative data from the 2008-2011 KNHANES, low pulmonary function was found to be associated with low muscle mass in community-dwelling older Korean adults.

Cited by 68 publications

References 35 publications

Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults

Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults

Relationship between pulmonary function and physical performance among community‐living people: results from Look‐up 7+ study

Vitamin D status is associated with muscle strength and quality of life in patients with COPD: a seasonal prospective observation study

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