Low prevalence of vancomycin-resistant enterococci in clinical samples from hospitalized patients of the Canary Islands, Spain

Pérez-Hernández, Xiomara; Méndez-Álvarez, Sebastián; Delgado, Teresa; Moreno, A; Reyes-Darias, José Antonio; López, Arturo Bados; Villar, Jesús Monterrubio; González, Agustín; Sánchez, Antonio Manuel Martı́n; Macía, Manuel; Claverie-Martı́n, Félix

doi:10.1007/s10123-002-0075-y

Cited by 12 publications

(7 citation statements)

References 20 publications

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“…Our finding was higher than the prevalence reported in the studies from Spain (0.7%), 24 France (1.0%), 25 Europe (4.0%) 26 and Canada (6.0%) 27 whereas lower than that of the United States (35.5%) 28 . North America (21%), 23 Belgium (12.8%), 29 Germany (9.8%) and 30 the United Kingdom (9.2%) 31 .…”

Section: Discussioncontrasting

confidence: 86%

“…It is closer to the prevalence of 11.9%, reported by a surveillance study among 4018 Enterococci species in the Asia Pacific region and lower than the reported prevalence of 23% by a meta-analysis among the patients with malignancy in Asia. 22,23 Our finding was higher than the prevalence reported in the studies from Spain (0.7%), 24 France (1.0%), 25 Europe (4.0%) 26 and Canada (6.0%) 27 whereas lower than that of the United States (35.5%). 28 North America (21%), 23 Belgium (12.8%), 29 Germany (9.8%) and 30 the United Kingdom (9.2%).…”

Section: Discussioncontrasting

confidence: 72%

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Prevalence of vancomycin‐resistant enterococci in Asia—A systematic review and meta‐analysis

et al. 2021

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Enterococci are gram-positive flora of the human intestine, of which E. faecalis and E. faecium are responsible for the majority of the infections in humans amongst at least 59 validly published species. 1,2 They are common causes of some serious infections such as endocarditis, urinary tract infection, wound infection and nosocomial bacteremia. [3][4][5] Enterococci are resistant to a wide range of antimicrobials used in the treatment of gram-positive bacterial infection and inherent resistance is shown to aminoglycosides, clindamycin and co-trimoxazole. 3,6 They also have the ability for the acquisition of resistant genes to antimicrobials through mutations or attainment

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Section: Discussioncontrasting

confidence: 86%

Section: Discussioncontrasting

confidence: 72%

Prevalence of vancomycin‐resistant enterococci in Asia—A systematic review and meta‐analysis

et al. 2021

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“…The phenotypic methods such as E-test are the convenient and useful meth-ods for determining of MIC values for vancomycin in enterococci. Our result are in accordance with the other studies which conducted by Sharifi et al in Iran, but, in contrast to the results of the study which performed by Pérez-Hernández et al 13,17 Horizontal gene transfer has an important role for the dissemination of resistance genes in enterococci and transposon (Tn1546) also has an important role for the dissemination of vancomycin resistance genes. Although primarily vanA cluster (Tn1546 and Tn5482) was identified in E. faecium, it has also been detected in E. faecalis.…”

Section: Discussionsupporting

confidence: 92%

Investigation of the Prevalence of vanA and vanB genes in vancomycin resistant enterococcus (VRE) by Taq Man real time PCR Assay

Mirzaei¹,

Farivar²,

Juhari³

et al. 2013

Jmid

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Objective: Enterococci are important nosocomial agents and due to their potential antimicrobial resistance they have a significant role in the dissemination of resistance genes. Currently, these species are described as healthcare concern. The aim of this study was to determine vanA and vanB genes in vancomycin resistant enterococci (VRE) strains isolated from the various clinical samples in the hospitals in Iran.Methods: Susceptibility of 235 strains to vancomycin was screened as minimum inhibitory concentration (MIC) by Etest. The genes encoding modifying vancomycin precursor's dipeptide termini named as vanA and vanB genes were targeted by Taq Man real time PCR assay in vancomycin resistant and vancomycin intermediate resistant Enterococcus faecalis and Enterococcus faecium strains.Results: A total of 235 enterococci were isolated from the clinical specimens. One hundred and ninety three (82.1%) of them were defined as E. faecalis, 33 (14.0%) E. faecium, 1/235 (0.4%) E. avium, 1/235 (0.4%) E. raffinosus and 7/235 (3.0%) E. galinarium. The prevalence of vancomycin resistance was 13.6% (32/235) consisting of 18/235 (7.7%) E. faecalis and 6.0% (14/235) E. faecium. Among the 32 VRE strains, a total of 36 vanA and vanB genes were detected (some isolates had both vanA and vanB genes). These resistance genes were not detected in 5 out of 32 (15.6%) isolates.Conclusion: E. faecalis was more common in clinical samples and vanA (58.3%) gene was the predominant gene among the VRE isolates. The current study showed that Taq Man real time PCR assay is the useful, precise and rapid detection of vancomycin resistance genes. J Microbiol Infect Dis 2013;3(4): 192-198 Mirzaei B, et al. Detection of vanA and vanB genes in VRE 193

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“…Some studies have reported a lower prevalence, eg, in Spain only three cases were resistant to vancomycin from 437 Enterococcus samples. 54 A prevalence of 6.7% was reported in a study in Canada, 55 9% in a study in New York, 56 and 2%–9% in a separate study in the USA. 57 – 60 In soEurope, a prevalence of 1% in France and 59% in Portugal was reported.…”

Section: Discussionmentioning

confidence: 94%

Prevalence of vancomycin resistance among isolates of enterococci in Iran: a systematic review and meta-analysis

Moghimbeigi¹,

Moghimbeygi²,

Dousti³

et al. 2018

AHMT

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IntroductionEnterococcus is responsible for 10% of hospital-acquired infections. The purpose of this review was to evaluate the prevalence of vancomycin-resistant Enterococcus (VRE) isolates in Iran using a meta-analysis method.Materials and methodsIranian databases, including Magiran and IranDoc, and international databases, including PubMed and MedLib, were examined carefully, and a total of 20 articles published between 2000 and 2011 were extracted. The data were subjected to meta-analysis and random-effects models. In addition, heterogeneous studies were assessed using the I2 index. Finally, the data were analyzed using R and STATA software.ResultsThe results showed that the strain of Enterococcus faecalis had been more common than Enterococcus faecium in clinical infection (69% vs 28%). However, resistance to vancomycin was higher among strains of E. faecium compared with strains of E. faecalis (33% vs 3%). The complete resistance, intermediate resistance, and sensitivity to vancomycin among Enterococcus isolates were 14% (95% CI: 11, 18), 14% (95% CI: 5, 23), and 74% (95% CI: 65, 83), respectively. The resistance patterns, depending on the sample type, did not show a significant difference. In addition, the resistance of isolated strains to vancomycin in outpatients was significantly higher than that in inpatients (16% vs 1%). Moreover, 80%–86% of resistant strains were genotype van A and 14%–20% of resistant strains were genotype van B.ConclusionThe findings of the present review show that there is a high frequency of resistant Enterococcus in Iran. Therefore, consideration of the prevalence and frequency of subjected resistant strains can be helpful for decision makers to implement proper health policies in this direction.

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Low prevalence of vancomycin-resistant enterococci in clinical samples from hospitalized patients of the Canary Islands, Spain

Cited by 12 publications

References 20 publications

Prevalence of vancomycin‐resistant enterococci in Asia—A systematic review and meta‐analysis

Prevalence of vancomycin‐resistant enterococci in Asia—A systematic review and meta‐analysis

Investigation of the Prevalence of vanA and vanB genes in vancomycin resistant enterococcus (VRE) by Taq Man real time PCR Assay

Prevalence of vancomycin resistance among isolates of enterococci in Iran: a systematic review and meta-analysis

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