Low prevalence of IgE to cross-reactive carbohydrate determinants in beekeepers

Carballada, F.; Gonzalez-Quintela, Arturo; Núñez, Ramón; Vidal, Carmen; Boquete, M.

doi:10.1016/j.jaci.2011.08.002

Cited by 9 publications

(6 citation statements)

References 8 publications

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“…In Vidal et al study, CCD sensitization was not significantly associated with age, rural residence, alcohol consumption or smoking [24]. On the other hand, among beekeepers, the presence of anti-CCD IgE was positively associated with atopy and higher levels of serum total IgE [23].…”

Section: Discussionmentioning

confidence: 84%

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Identification of cross-reactive carbohydrate determinants in subjects reporting work-related respiratory symptoms

Wiszniewska

Zgorzelska-Kowalik

Nowakowska‐Świrta

et al. 2015

Int J Occup Med Environ Health

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Objectives: The role of cross-reactive carbohydrate determinants (CCDs) in diagnostics of occupational allergy remains unclarified and its clinical relevance is still questioned. The aim of the study was to assess the frequency of positive response to CCDs in the subjects with suspected occupational allergy and the relationship between other diagnostic test results and final diagnosis. Material and Methods: The study group included 201 patients. They underwent clinical examination, skin prick test (SPT) to common and occupational allergens, specific serum immunoglobulin (sIgE) determinations, spirometry and specific inhalation challenge test. Moreover, sIgE to CCDs from bromelain was assessed in all subjects. Results: Occupational respiratory allergy was recognized in 64.3% of CCD-positive and 52.4% of CCD-negative patients. Positive SPT results to common and occupational allergens were found in 64.3% and 35.7% of CCD-positive subjects, respectively. In all subjects with CCDs, the sIgE to grass pollens as well as to occupational allergens were detected. The total IgE level > 100 kU/l was significantly associated with the presence of sIgE to CCDs. Conclusions: sIgE to CCDs were found in 7% of subjects suspected to suffer from occupational respiratory allergy. The presence of CCDs is not significantly associated with occupational respiratory allergy. It is also not more frequent in subjects reporting work-related respiratory symptoms in whom occupational allergy was not confirmed. The elevated total IgE level was related with CCD positivity. In patients with suspected occupational allergy, the presence of sIgE to CCDs in serum did not indicate the irrelevance of positive sIgE to occupational allergens. Key words:Occupational allergy, Cross-reactive carbohydrate determinants, CCDs, Work-related respiratory symptoms MATERIAL AND METHODSThe study group included 201 patients (bakers, farmers, healthcare workers (HCWs), carpenters and single other occupations, i.e., veterinarian, poultry farm worker, cleaner, seamstress, ceramics decorator, leather cutter, pharmacist) suspected to be affected by occupational respiratory allergy (asthma and/or rhinitis), diagnosed at our Department of Occupational Diseases between 2008 and 2010. After completion of the diagnostic procedures, the study group was divided taking into account the final diagnosis (subjects with occupational respiratory allergy vs. suspected occupational allergy) and anti-CCD IgE determination results (CCD-positive vs. CCD-negative subjects) to compare statistically the various parameters. The subjects were administered a questionnaire that included e.g., a history of respiratory symptoms (rhinitis, itching, nasal blockage, cough, wheezing, shortness of breath, chest tightness), skin symptoms, personal and family history of atopy, exposure to pet allergens at home, medication use, and smoking habits. Skin prick tests (SPT) were performed on the volar part of the forearm with a standard battery of common allergens including tree and grass pollens, Der...

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Section: Discussionmentioning

confidence: 84%

“…In our study, sIgE to CCDs was found in 7% of subjects with suspected occupational respiratory allergy disease, mainly among farmers (11.4%). Lower prevalence of IgE sensitization to CCDs has been observed among beekeepers (2.6%) [23].…”

Section: Discussionmentioning

confidence: 99%

Identification of cross-reactive carbohydrate determinants in subjects reporting work-related respiratory symptoms

Wiszniewska

Zgorzelska-Kowalik

Nowakowska‐Świrta

et al. 2015

Int J Occup Med Environ Health

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“…It was discussed that the high venom exposure due to repeated bee stings induces tolerance to CCD indicated by anti-CCD IgG antibodies in most of these serum samples [17]. It was discussed that the high venom exposure due to repeated bee stings induces tolerance to CCD indicated by anti-CCD IgG antibodies in most of these serum samples [17].…”

Section: Incidence and Clinical Relevance Of Cross Reactive Carbohydrmentioning

confidence: 99%

Cross-reacting carbohydrate determinants and hymenoptera venom allergy

Grundmann¹,

Stöcker²

2013

Current Opinion in Allergy &Amp; Clinical Immunology

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“…Most probably, the high venom exposure after repeated stinging episodes could provoke a status of immunologic tolerance through the induction of regulatory T cells, as previously described. 9 Notably, beekeepers also had the lowest levels of serum total IgE among the populations studied (Table E2). The association between hypersensitivity symptoms and CCD-sIgE could indicate that sensitization to the glycosydic epitope is a risk factor for the development of clinical allergy to the venom.…”

mentioning

confidence: 93%

“…9 Studies on beekeepers offer the opportunity to investigate such differences. Future longitudinal studies in this population could elucidate the role of repeated stings in the balance between sensitization and tolerance to the venom and its glycosydic epitopes.…”

mentioning

confidence: 99%