Low prevalence of HPV infection and its natural history in normal oral mucosa among volunteers on Miyako Island, Japan

Kurose, Kazuyo; Terai, Masanori; Soedarsono, Nurtami; Rabello, Doralina do Amaral; Nakajima, Yoshikazu; Burk, Robert D.; Takagi, Minoru

doi:10.1016/j.tripleo.2003.12.029

Cited by 69 publications

(67 citation statements)

References 36 publications

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“…One study evaluated persistence of oral HPV infection at baseline and a subsequent two and a half year time-point among only 4 subjects. 5 In a study of husband-wife pairs, only overall HPV infection status was considered.6 Because analysis of type-specific HPV infection was not performed, meaningful estimates of incidence and clearance could not be obtained. Our study was designed to evaluate the feasibility of studying the natural history of oral HPV infection prior to initiating a larger and longer cohort study.…”

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confidence: 99%

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Six‐month natural history of oral versus cervical human papillomavirus infection

D’Souza

Fakhry

Sugar

et al. 2007

Intl Journal of Cancer

157

138

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Human papillomavirus (HPV) infection is etiologically associated with a subset of oral cancers, and yet, the natural history of oral HPV infection remains unexplored. The feasibility of studying oral HPV natural history was evaluated by collecting oral rinse samples on 2 occasions at a 6-month interval from 136 HIV-positive and 63 HIV-negative participants. Cervical vaginal lavage samples were concurrently collected for comparison. HPV genomic DNA was detected in oral and cervical samples by consensus primer PCR and type-specified for 37 HPV types. The sixmonth cumulative prevalence of oral HPV infection was significantly less than for cervical infection (p < 0.0001). HIV-positive women were more likely than HIV-negative women to have an oral (33 vs. 15%, p 5 0.016) or cervical (78 vs. 51%, p < 0.001) infection detected. Oral HPV infections detected at baseline were as likely as cervical infections to persist to 6 months among HIVnegative (60% vs. 51%, p 5 0.70) and HIV-positive (55% vs. 63%, p 5 0.27) women. Factors that independently elevated odds for oral HPV persistence differed from cervical infection and included current smoking (OR 5 8, 95% CI 5 1.3-53), age above 44 years (OR 5 20, 95% CI 5 4.1-83), CD4 < 500 (OR 5 6, 95% CI 5 1.1-26), use of HAART therapy (OR 5 12, 95% CI 5 1.0-156), and time on HAART therapy (trend p 5 0.04). The rate of oral HPV infections newly detected at follow-up was significantly lower than cervical infection among HIV-positive (p < 0.001) and HIV-negative women (p < 0.001). Our study not only demonstrates that it is feasible to study the natural history of oral HPV infection with oral rinse sampling, but also indicates that oral and cervical HPV natural history may differ. ' 2007 Wiley-Liss, Inc.Key words: oral; HPV; natural history; comparison; cervical; human papillomavirus; infectionThe majority of oral cancers are attributable to alcohol and tobacco use, however a subset are etiologically associated with human papillomavirus (HPV) infection.1 Case-control studies have shown that oral HPV infection elevates risk of oral cancer, 2,3 and therefore is likely a prerequisite for cancer development. Although natural history studies of oral infection are yet to be performed, seropositivity to HPV16 increases risk for incident oral cancer, supporting a temporal association between infection and cancer risk. While the natural history of cervical HPV infection is well studied, it is unclear whether it is appropriate to extrapolate data from the cervical literature to oral HPV infection. Unfortunately, 2 studies with consecutive measures of oral HPV infection provide limited insight into its natural history. One study evaluated persistence of oral HPV infection at baseline and a subsequent two and a half year time-point among only 4 subjects. 5 In a study of husband-wife pairs, only overall HPV infection status was considered.6 Because analysis of type-specific HPV infection was not performed, meaningful estimates of incidence and clearance could not be obtained. Our study was designed ...

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confidence: 99%

mentioning

confidence: 99%

Six‐month natural history of oral versus cervical human papillomavirus infection

D’Souza

Fakhry

Sugar

et al. 2007

Intl Journal of Cancer

157

138

View full text Add to dashboard Cite

show abstract

“…(28,22). All MY-PCR reactions were performed in the Biometra T-gradient thermocycler (Biometra GmbH, Goettingen, Germany) using the following procedure: (1) incubation with UNG at 558C for 2 min; (2) pre-denaturing at 958C for 5 min; (3) annealing of oligonucleotides at 558C for 30 sec; (4) elongation at 728C for 45 sec; (5) denaturing at 958C for 30 sec; (6) final elongation at 728C for 7 min.…”

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Detection of Anti-HPV11-L1 Antibodies in Immune Sera from Patients Suffering from Recurrent Respiratory Papillomatosis Using ELISA

Durzyńska

Błażejewska

Szydłowski³

et al. 2010

Viral Immunology

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CitationDetection of anti-HPV11-L1 antibodies in immune sera from patients suffering from recurrent respiratory papillomatosis using ELISA. Infection with human papillomaviruses (mostly HPV6 and HPV11) may lead to recurrent respiratory papillomatosis (RRP), a chronic disease affecting 2-4/100,000 people. Papillomas have to be removed surgically so patients can breathe normally. Papillomas often grow back and some patients are subjected to a number of operations. In general, asymptomatic HPV-positive people have low levels of antiviral antibodies in their sera, as the human humoral response is weak due to HPV's biology. In patients suffering from RRP who have undergone multiple surgeries, a blood-epithelium barrier breach stimulates the production of anti-HPV antibodies. Our study's aim was to produce HisTag-HPV11-L1 major capsid protein in E. coli cells, and to purify it. We also sought to detect anti-HPV11-L1 antibodies in antisera obtained from RRP patients using ELISA. Clinical samples were collected from 47 patients with RRP (antisera and papillomas), and from 32 controls (sera and oral swabs), from the Wielkopolska region of Poland. Antisera and control sera were used to coat microplates, HisTag-HPV11-L1 antigen was applied, and antibody-antigen complexes were detected by anti-HisTag monoclonal antibody in an ELISA assay. Simultaneously, total cellular DNA was extracted from papillomas and oral squamous cells obtained from controls. All DNA samples were screened for HPV DNA using MY-PCR. All patients were HPV-positive (30% for HPV6 and 70% for HPV11). Statistically significant correlations were found between the amount of anti-HPV11-L1 antibodies in the sera of RRP patients and the number of surgical procedures they underwent. Although HPV virus-like particles are most often used for anti-HPV antibody detection, the ELISA method presented herein is another viable option for use in RRP patients.

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“…La presencia del genoma viral en la cavidad oral de sujetos sin patología ha sido analizada por diversos autores con frecuencias que varían de 0,6 a 81% [7][8][9][10] . Se ha asociado al sexo oral sin protección como el principal factor de riesgo a la infección oral por genotipos presentes en el tracto genito-urinario 11,12 .…”

Section: Introductionunclassified

Epidemiología de la infección oral por VPH en sujetos jóvenes sanos

Cab-Sánchez

Hernández-Solís

Rueda-Gordillo

et al. 2017

Rev. chil. infectol.

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Low prevalence of HPV infection and its natural history in normal oral mucosa among volunteers on Miyako Island, Japan

Cited by 69 publications

References 36 publications

Six‐month natural history of oral versus cervical human papillomavirus infection

Six‐month natural history of oral versus cervical human papillomavirus infection

Detection of Anti-HPV11-L1 Antibodies in Immune Sera from Patients Suffering from Recurrent Respiratory Papillomatosis Using ELISA

Epidemiología de la infección oral por VPH en sujetos jóvenes sanos

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