Low prevalence of CCR5-Δ32, CCR2-64I and SDF1-3′A alleles in the Baiga and Gond tribes of Central India

Kumar, Ashish; Mahla, Ranjeet Singh; Kumar, Sushil; Ingle, Harshad; Yadav, Tushar; Mishra, Anamika; Raut, Ashwin Ashok; Kumar, Himanshu

doi:10.1186/s40064-015-1238-6

Cited by 11 publications

(3 citation statements)

References 19 publications

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“…Numerous studies were reported at the context of disease epidemiology and genetics, upon various indian tribal communities, who are highly isolated both demographically and topogra phically, from the mainstream indian populations [4][5][6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Association of ACE DD Genotype with Hypertension among the Tribal Populations of South India

Paramasivam

Nandakumar

Arumugam

et al. 2016

ILNS

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The Renin-Angiotensin System (RAS) is an important regulator of the blood pressure(BP). The level of the vasoactive peptide Angiotensin-II, is mainly determined by the RAS enzyme, angiotensin converting enzyme-1 (ACE-1). Polymorphisms in ACE gene is reported to be associated with hypertension in various populations worldwide. We investigated the association of ACE I/D polymorphisms with hypertension among the tribal populations of South India. Samples were collected from hypertensive patients (n = 33) and healthy controls (n = 37). Genotyping was performed using Polymerase chain reaction (PCR) with allele specific primers. The DD genotype is significantly observed among the cases (OR = 1.0) . Specifically, the DD genotype is more evident among the females (OR = 0.705) than males (OR = 1.22) and is analysed to be associated with hypertension among the tribal populations of South India.

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Section: Introductionmentioning

confidence: 99%

Association of ACE DD Genotype with Hypertension among the Tribal Populations of South India

Paramasivam

Nandakumar

Arumugam

et al. 2016

ILNS

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“…Among other African populations, frequencies ranging from 10%–30% have been reported. The frequencies of the CCR2-64I allele in African populations have been higher than what has been observed in Caucasians (7%–10%), while Asian populations show a wider range from 1%–30% 22. A study on subjects selected from different regions of Jordan showed that this allele is common among Jordanians, with a prevalence of 17.5% 8.…”

Section: Discussionmentioning

confidence: 88%

CCR2 Genetic Polymorphism And Its Potential Effect On HIV Acquisition In A Population Of Children Living In The Northern Region Of Cameroon

Ngoufack

Nkenfou

Tiedeu

et al. 2019

TACG

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Background and objectivesThe association of chemokine receptor-2 (CCR2) polymorphism with HIV transmission or disease progression remains highly controversial. The role of CCR2-64I allele in HIV infection may differ from one population to another because of their genetic background. The objectives of this study were to characterize the CCR2 genetic polymorphism and to determine its potential effect in HIV acquisition in children living in the Northern Region of Cameroon.Materials and methodsA cross-sectional study was carried out in five health facilities in the Northern region of Cameroon. DNA was extracted from the Buffy coat of each participant using the QIAamp®DNA mini kit. The DNA extract was then subjected to polymorphic analyses. CCR2 genotypes were analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The Chi-Squared test was used for the assessment of the Hardy-Weinberg equilibrium.ResultsA total of 134 children under 15 years comprised of 38 HIV-exposed infected (28.36%) and 96 HIV-exposed un-infected (71.64%) participants were recruited. Prevalences of 44.78% wild type homozygous, 48.52% heterozygous and 6.7% mutant homozygous alleles were found in the overall population. An allelic frequency of 29.69% for the mutant allele CCR2-64I was found in HIV-exposed un-infected individuals as compared to 34.21% in HIV-infected children (p=0.47).ConclusionThe CCR2-64I allele is relatively common in the Northern Region of Cameroon, with a similar distribution among HIV-exposed un-infected and infected children. As this allele alone does not seem to confer protection against HIV-1 infection, further studies using genotype-combination of CCR2 polymorphism and other single nucleotide polymorphisms would be of great relevance in both HIV prevention and novel therapeutic strategies.

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“…129, 130, 136, 138, 139, 140 A twentieth century disease, HIV-1 has not been around long enough for selection pressure to drive CCR5 Δ32 from 0 to 10% in European populations. 141 Another pathogen, Yersinia pestis , the cause of the bubonic plague, was proposed as an agent of positive selection for CCR5 Δ32.…”

Section: Introductionmentioning

confidence: 99%

Pharmacogenomic implications of the evolutionary history of infectious diseases in Africa

et al. 2016

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As the common birthplace of all human populations, modern humans have lived longer on the African continent than in any other geographical region of the world. This long history, along with the evolutionary need to adapt to environmental challenges such as exposure to infectious agents, has led to greater genetic variation in Africans. The vast genetic variation in Africans also extends to genes involved in the absorption, distribution, metabolism and excretion of pharmaceuticals. Ongoing cataloging of these clinically relevant variants reveals huge allele-frequency differences within and between African populations. Here, we examine Africa's large burden of infectious disease, discuss key examples of known genetic variation modulating disease risk, and provide examples of clinically relevant variants critical for establishing dosing guidelines. We propose that a more systematic characterization of the genetic diversity of African ancestry populations is required if the current benefits of precision medicine are to be extended to these populations.

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Low prevalence of CCR5-Δ32, CCR2-64I and SDF1-3′A alleles in the Baiga and Gond tribes of Central India

Cited by 11 publications

References 19 publications

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

<p>CCR2 Genetic Polymorphism And Its Potential Effect On HIV Acquisition In A Population Of Children Living In The Northern Region Of Cameroon</p>

Pharmacogenomic implications of the evolutionary history of infectious diseases in Africa

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