Low-Power Laser Irradiation (LPLI): A Clinical Point of View on a Promising Strategy to Improve Liver Regeneration

Araújo, Tiago Gomes; Oliveira, Alexandre G.; Teixeira, Antônio Roberto Franchi

doi:10.15171/jlms.2018.40

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…The low-power laser of 632.5 nm showed that it can increase calcium, thereby helping the proliferation of cells. 10,17,18 ΔΨm/ATP/cAMP/JNK/AP-1 Pathway The low-level laser could result in an increase in cAMP and consequently jNK phosphorylation, thereby increasing AP1. AP-1 enhances the expression of the genes involved in proliferation, survival, and angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Photobiomodulation Therapy on the Differentiation, Proliferation, and Migration of the Mesenchymal Stem Cell: A Review

et al. 2019

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Introduction: The purpose of this study is to investigate the effect of a low-power laser on the proliferation, migration, differentiation of different types of mesenchymal stem cells (MSCs) in different studies. Methods: The relevant articles that were published from 2004 to 2019 were collected from the sources of PubMed, Scopus, and only the articles specifically examining the effect of a lowpower laser on the proliferation, differentiation, and migration of the MSCs were investigated. Results: After reviewing the literature, only 42 articles were found relevant. Generally, most of the studies demonstrated that different laser parameters increased the proliferation, migration, and differentiation of the MSCs, except the results of two studies which were contradictory. In fact, changing the parameters of a low-power laser would affect the results. On the other hand, the source of the stem cells was reported as a key factor. In addition, the combination of lasers with other therapeutic approaches was found to be more effective. Conclusion: The different parameters of lasers has been found to be effective in the proliferation, differentiation, and migration of the MSCs and in general, a low-power laser has a positive effect on the MSCs, helping to improve different disease models.

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Section: Introductionmentioning

confidence: 99%

The Effect of Photobiomodulation Therapy on the Differentiation, Proliferation, and Migration of the Mesenchymal Stem Cell: A Review

et al. 2019

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“…Activated TPKR can activate the catalytic activity of phospholipase C (PLC)-gamma, thereby increasing the concentration of diacylglycerol and inositol triphosphate (IP3) in the cytoplasm. 56 IP3 can contribute to increased calcium levels in the endoplasmic reticulum, activating protein kinase C (PKC). PKC was first described as a Ca 2+ activated, phospholipid-dependent serine/threonine protein kinase, having different functions, including cell proliferation and differentiation.…”

Section: Tpkr/plc-gamma/pkc Pathwaymentioning

confidence: 99%

Photobiomodulation improves the therapeutic efficacy of mesenchymal stem cells in regenerative medicine

Woo¹,

Abueva²

2022

Medical Lasers

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Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into many other cell types typically isolated from adult tissue sources. The therapeutic potential of MSCs is considerable in regenerative medicine and has advanced over the years. Consequently, methods and tools that improve the therapeutic efficacy of MSCs have also been devised and utilized. Recent strategies used to enhance the therapeutic efficacy of MSC include photobiomodulation (PBM), which can increase proliferation and enhance differentiation into target cell types. PBM is a non-thermal, non-invasive method that utilizes light from coherent or non-coherent sources to influence metabolic activity at the cellular level and has been found to increase cell proliferation and migration in vitro, in vivo, and in clinical studies. However, little is known of the mechanism responsible for the effects of PBM on MSCs or its potential as an adjunctive treatment, which obscures appreciation of its regenerative applications. This review summarizes reports on the effects of PBM on different MSCs and provides perspectives on the ability of PBM to improve the therapeutic efficacy of MSCs in regenerative medicine.

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“…The advantage of the laser method is that it can provide results that are easily controlled precisely and more accurately [ 12 ]. The use of low-power lasers to stimulate acupuncture points is fast, simple, and harmless at each point [ 13 ], so this technology is relatively cheaper because one device can be used en masse and with low operating costs rather than using acupuncture through a needle because the time can be adjusted according to the desired dose, so that, in 1 minute, at least 6 birds can undergo laser puncture. According to Ng et al [ 14 ], acupuncture treatment can effectively overcome reproductive problems and be free from side effects.…”

Section: Introductionmentioning

confidence: 99%

Increasing Quantity and Internal Quality of Japanese Quail (Coturnix coturnix japonica) Eggs by Shooting Laser Puncture at Reproductive Acupuncture Points

Warsito

Adikara

Megasari

et al. 2021

Veterinary Medicine International

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This study aims to determine the effect of laser puncture shooting on the reproductive acupuncture points of Japanese quail (Coturnix coturnix japonica) egg quantity (egg production) and internal egg quality (Haugh unit, yolk index, and yolk colour). This research was conducted for 30 days using a sample of Japanese quail aged 4 weeks because for the first 2 weeks, the quail did not produce and it was in production in the last 2 weeks. There were 4 treatments and 25 replications each. So, there were a total of 100 quails. Laser puncture shooting was carried out at 3-day intervals at the Ova point and 6-day intervals at Hu Men, Bei Ji, and Wei Gen points. So, on the first day, laser puncture shooting was carried out at 4 points, on the 4th day, only at 1 point, and then, on the 7th day, it returned to 4 points. And so, it was carried out for 4 weeks. T0 (−) was considered as a negative control because quails are not given laser puncture shooting; T0 (+) was considered as a positive control because quails are treated with laser puncture shooting which is deactivated or a dose of 0 Joule; T1 was a group treated with laser puncture shooting at a dose of 0.2 Joule, and T2 was a group treated with laser puncture shooting at a dose of 0.5 Joule. Then, the research results were analyzed using Analysis of Variance and followed by Duncan’s Multiple Range Test. Laser puncture shooting at the reproductive acupuncture point of Japanese quail (Coturnix coturnix japonica) can increase the quantity of eggs ( p < 0.05 ). While the results of the egg internal quality in the form of the Haugh unit value and the yolk index increased ( p < 0.05 ), the value of the yolk colour did not change compared to the control ( p > 0.05 ). Laser puncture shooting at the reproductive acupuncture point of Japanese quail (Coturnix coturnix japonica) can increase egg quantity (egg production) and internal egg quality (Haugh unit and yolk index) with the best dose of 0.5 Joule.

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Low-Power Laser Irradiation (LPLI): A Clinical Point of View on a Promising Strategy to Improve Liver Regeneration

Cited by 6 publications

References 21 publications

The Effect of Photobiomodulation Therapy on the Differentiation, Proliferation, and Migration of the Mesenchymal Stem Cell: A Review

The Effect of Photobiomodulation Therapy on the Differentiation, Proliferation, and Migration of the Mesenchymal Stem Cell: A Review

Photobiomodulation improves the therapeutic efficacy of mesenchymal stem cells in regenerative medicine

Increasing Quantity and Internal Quality of Japanese Quail (Coturnix coturnix japonica) Eggs by Shooting Laser Puncture at Reproductive Acupuncture Points

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