Low plasma vitamin C in Alzheimer patients despite an adequate diet

Rivière, Stéphanie; Birlouez‐Aragon, Inès; Nourhashémi, F.; Vellas, Bruno

doi:10.1002/(sici)1099-1166(1998110)13:11<749::aid-gps860>3.0.co;2-t

Cited by 138 publications

(48 citation statements)

References 21 publications

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“…Vitamin C concentration in plasma or serum is also found to be significantly lower in AD in most literature [10, 16, 25, 54, 60, 62, 63]. Furthermore, vitamin C is especially significantly lower in moderate and severe AD [62].…”

Section: Resultsmentioning

confidence: 99%

The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer’s Disease: A Systematic Review

Chang

Tsai

et al. 2014

BioMed Research International

114

116

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Purpose. Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies. Methods. PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD. Results and Conclusion. Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD.

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Section: Resultsmentioning

confidence: 99%

The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer’s Disease: A Systematic Review

Chang

Tsai

et al. 2014

BioMed Research International

114

116

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“…Though the etiology of the disease is not completely elucidated, ROS and oxidative stress has been linked to disease progression [123]. As AD patients have been reported to have decreased levels of plasma VitC, investigations into the role of antioxidants including VitC in AD pathogenesis has been conducted [124,125]. In animal models of AD, VitC supplementation has been reported to reduce some of the cognitive dysfunction seen in control animals [126,127].…”

Section: Vitamin C Deficiency and Cognitive Dysfunctionmentioning

confidence: 99%

Does Vitamin C Deficiency Affect Cognitive Development and Function?

2014

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Vitamin C is a pivotal antioxidant in the brain and has been reported to have numerous functions, including reactive oxygen species scavenging, neuromodulation, and involvement in angiogenesis. Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(−/−) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring. Furthermore, vitamin C deficiency has been proposed to play a role in age-related cognitive decline and in stroke risk and severity. The present review discusses the available literature on effects of vitamin C deficiency on the developing and aging brain with particular focus on in vivo experimentation and clinical studies.

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“…The primary role of CAT is to scavenge H 2 O 2 that has been generated by free radicals or by SOD in its -removal of superoxide anions, and convert it to water. [29] The destruction of superoxide radicals is catalysed by SOD, which is an important defence system against oxidative damage. From our experimental results of the aforesaid antioxidant enzyme activities in serum and liver tissues, it is clear that nimesulide significantly decreased SOD, CAT, GSH activities in nimesulide treated experimental group compared to -control group, BH treated control group, Hepamerz treated control group, Hepamerz pretreated nimesulide treated experimental group and BH pretreated nimesulide treated experimental group.…”

Section: Discussionmentioning

confidence: 99%

The protective role of Benincasa hispida on nimesulide - induced hepatotoxicity in albino rat model

Roy¹,

Das²

2011

Int J Green Pharm

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The objective of the present investigation was to study the protective role of aqueous extract of pulps of Benincasa hispida (BH) on nimesulide-induced hepatotoxicity model in adult male albino rats. Hepatotoxicity in rats was caused by nimesulide at a dose of 10 mg-/ ml/kg body weight. Hepamerz (L-ornithine, L-aspartate) was administered orally as standard hepatoprotective agent for 14 consecutive days prior to nimesulide treatment at a dose of 10 mg-/ml/kg body weight. This drug has many side effects. These side effects have prompted the scientific world for the search of alternative herbal remedies of liver damage. In our country BH is easily available, cheap and has no side effects. The aqueous pulp extract of BH was administered orally to rats daily for 14 days before nimesulide treatment. The biochemical parameters were investigated. The results indicated that biochemical changes produced by nimesulide were restored to normal by aqueous extract of pulps of BH. The aqueous pulp extract of BH showed significant hepatoprotective effect through the modulation of antioxidant-mediated mechanism by altering serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase, superoxide dismutase and catalase activities and reduced glutathione and lipid peroxidation levels against nimesulide-induced hepatotoxicity model in rats.

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Low plasma vitamin C in Alzheimer patients despite an adequate diet

Cited by 138 publications

References 21 publications

The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer’s Disease: A Systematic Review

The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer’s Disease: A Systematic Review

Does Vitamin C Deficiency Affect Cognitive Development and Function?

The protective role of Benincasa hispida on nimesulide - induced hepatotoxicity in albino rat model

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