The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer’s Disease: A Systematic Review

Chang, Ya‐Ting; Chang, Wen-Neng; Tsai, Nai‐Wen; Huang, Chih‐Cheng; Kung, Chia-Te; Su, Yu‐Jih; Lin, Wei-Che; Cheng, Ben-Chung; Su, Chih-Min; Chiang, Yu Chung; Lu, Cheng-Hsien

doi:10.1155/2014/182303

Cited by 114 publications

(122 citation statements)

References 75 publications

(166 reference statements)

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“…During aging, however, there is a clear accumulation of free radicals and associated damage in various tissues [17][18][19] -and this constitutes the basis for the free radical theory of aging. In addition, enhanced oxidative stress (OS) contributes to the pathogenesis of many age-related diseases [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging

Müller

Gottlieb

Correa

et al. 2015

Cellular Immunology

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Aging has been associated with increased generation of free radicals as well as immunosenescence. Previous studies have identified older individuals with inverted T CD4:CD8 cell ratio and increased immunity to cytomegalovirus (CMV). Here, we investigated markers of oxidative stress and antioxidant defences in older individuals with inverted CD4:CD8 T-cell ratio. Sixty-one subjects were identified with inverted CD4:CD8 ratio. Older individuals with a CD4:CD8 ratio <1 had increased levels of plasma advanced oxidation protein products (AOPP) and ferric reducing ability of plasma (FRAP), but reduced levels of thiobarbituric acid reactive substances (TBARS) as compared to subjects with normal CD4:CD8 ratio. The CMV IgG serology was negatively correlated with CD4:CD8 ratio. These markers were more evident among elderly men than women. Our data suggest a close relationship between chronic CMV infection and oxidative profile in older individuals in the midst of its influence on the peripheral T-cell subsets.

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Section: Introductionmentioning

confidence: 99%

The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging

Müller

Gottlieb

Correa

et al. 2015

Cellular Immunology

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“…There is consistent evidence in literature showing the involvement of free radical-induced oxidative damage in the etiopathogenesis of AD, since oxidative stress is one of the earliest events in AD pathogenesis [18,[80][81][82]. Moreover, oxidative damage has been shown in the blood, CSF and brain of neurological patients with probable AD [83][84][85]. Post mortem studies on brain specimens collected from individuals affected by AD, evidenced extensive oxidative stress compared to healthy controls, i.e.…”

Section: Involvement Of Sam In Oxidative Stress and Neurodegenerationmentioning

confidence: 52%

Role of S-adenosylmethionine in the Modulation of Oxidative Stress- Related Neurodegeneration

Cavallaro¹,

Fuso²,

D’Erme³

et al. 2016

Int J Clin Nutr Diet

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S-adenosyl-L-methionine (SAM) is the main biological methyl donor in transmethylation reactions, consisting in the transferring of a methyl moiety to different substrates including DNA, proteins, lipids and RNA. SAM level in the organism decreases with aging and restoring the original levels through exogenous supplementation is an important tool for the improvement of many vital functions. Indeed, SAM deficiency may contribute to the onset of several diseases, i.e. depression, liver diseases, osteoarthritis and senile neurological disorders such as Alzheimer's and Parkinson's diseases. Recent evidences indicate that SAM may have an involvement in oxidative stress, a process which typically involves an alteration of cellular sulfur amino acids homeostasis. SAM is not only the principal methyl donor, but also a precursor of glutathione, the major endogenous antioxidant, whose role in counteracting oxidative stress is well known. In this review we will highlight the role of SAM not just as a methyl-donor but also as a regulator of different metabolic pathways involved in the antioxidant response in brain related disorders. Role of S-adenosylmethionine in the Modulation of Oxidative StressRelated Neurodegeneration Review ArticleOpen Access IntroductionThe interaction between environmental and genetic factors plays a fundamental role in inducing and modulating the aging processes towards brain disorders. Among environmental factors, diet and nutritional lifestyle have a key role in brain health through the alteration of the intake or the bioavailability of metabolites and cofactors. Specific nutritional factors have particular impact on one-carbon metabolism, which is a complex biochemical pathway regulated by the presence of folate, vitamin B12 and B6 (among other metabolites) and leading to the production of S-adenosyl-L-methionine (SAM), the main biological methyl donor in transmethylation reactions, consisting in the transferring of a methyl moiety to different substrates including DNA, proteins, lipids and RNA. This metabolism involves three interrelated biochemical pathways: folate cycle, transsulfuration pathway and methionine cycle. These three metabolic sequences were first combined and correlated in 1964 by Laster's group [1][2][3] giving the integrated point of view of transmethylation and transsulfuration pathways, linking sulfur amino acid metabolism to the provision of methyl groups for many biochemical processes. Normal functioning of this metabolic cycle is essential for growth and development and impairment of this metabolism; transmethylation efficiency is associated with many diseases like cardiovascular diseases [4][5], liver diseases [6-9], neural tube defects [10] and brain diseases [11][12][13][14][15][16]. One-carbon metabolism alterations, low methylation and oxidative stress are all linked to Late Onset Alzheimer's Disease (LOAD) [17][18][19][20][21][22][23][24] Moreover, wide confirmed reports underline the role of SAM dependent reactions in age related neurodegeneration also showi...

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“…Menopause is associated with an increase in oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) and the antioxidant system (3)(4)(5). Previous studies have demonstrated that oxidative stress is implicated in the pathogenesis of various chronic diseases (6)(7)(8)(9). Osteoporosis is a skeletal disorder characterized by compromised bone strength, predisposing patients to increased risk of fracture (10).…”

Section: Introductionmentioning

confidence: 99%

Effect of anthocyanin-rich bilberry extract on bone metabolism in ovariectomized rats

et al. 2017

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Abstract. Menopause is associated with increased oxidative stress, which serves a role, in part, in the pathogenesis of postmenopausal bone loss. Fruits and vegetables are rich in antioxidative nutrients and phytochemicals. Berries are a natural source of anthocyanins, and their intake may improve bone health. The aim of the present study was to determine the effect of an anthocyanin-rich bilberry extract (VME) on bone metabolism in an ovariectomized (Ovx) rat. Female Sprague-Dawley rats (12 weeks old) were randomly divided into the following four groups: Baseline, Sham, Ovx and Ovx+VME (n=8-12 rats per group). Rats in the Baseline group were sacrificed immediately, while those in the other groups were subjected to either sham operation (Sham) or bilateral Ovx (Ovx and Ovx+VME). Rats in the Ovx+VME group were administered VME daily at a dose of 500 mg/kg body weight. At 8 weeks after surgery, bone mass and bone histomorphometry were evaluated. The femur bone mineral density (BMD) in the Ovx group was significantly lower than that in the Sham group (P<0.01). Supplementation of VME in the Ovx rats did not result in an increase in BMD. Histomorphometric analyses revealed that Ovx resulted in decreased measures of bone volume and trabecular number and increased measures of osteoid volume, mineralizing surface and bone formation rates (all P<0.01), whereas VME had no significant effects on these parameters. The present findings indicate that VME did not alter bone metabolism in Ovx rats, suggesting that consumption of VME may not be helpful in preventing postmenopausal bone loss.

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The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer’s Disease: A Systematic Review

Cited by 114 publications

References 75 publications

The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging

The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging

Role of S-adenosylmethionine in the Modulation of Oxidative Stress- Related Neurodegeneration

Effect of anthocyanin-rich bilberry extract on bone metabolism in ovariectomized rats

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