Low Peptic Ulcer and High Gastric Cancer Prevalence in a Developing Country with a High Prevalence of Infection by Helicobacter pylori

Burstein, M; Monge, Eduardo; León-Barúa, Raúl; Lozano, Roberto; Berendson, R.; Gilman, Robert H.; Legua, H.; Rodriguez, Christina

doi:10.1097/00004836-199104000-00007

Cited by 72 publications

(28 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We (28) and others (50) have previously shown that 4 wk after treatment, a significant proportion of eradicated patients still have evidence of antral gastritis, and in a country with a high prevalence of gastric cancer, it is interesting to follow the evolution of this histological abnormality. However, duodenal ulcer patients are probably not representative of H. pylori-infected populations from developing countries, where gastric cancer is more frequent than duodenal ulcer (51). As confirmed by our observations during the follow-up period, duodenal ulcer patients do not develop atrophic gastritis (25), which probably explains their lower risk of gastric cancer compared to that of the general population or that of gastric ulcer patients (52).…”

Section: Discussionsupporting

confidence: 55%

The long-term reinfection rate and the course of duodenal ulcer disease after eradication of Helicobacter pylori in a developing country

Rollan¹

2000

The American Journal of Gastroenterology

View full text Add to dashboard Cite

OBJECTIVE:The aim of this study was to evaluate the effect of Helicobacter pylori (H. pylori) eradication on the natural history of duodenal ulcer disease and the reinfection rate after treatment in a developing country. METHODS:A total of 111 H. pylori-infected patients with duodenal ulcer were treated with either omeprazole or famotidine plus two antibiotics for 2 wk. Those failed to respond to treatment were retreated with bismuth-based triple therapy. RESULTS:The radication rate was 76% (95% CI: 67-83%). Eventually, H. pylori was eradicated in 96 of the 111 patients (86%), who were followed-up clinically and endoscopically for a mean of 37.2 months. The cumulative reinfection rate after eradication (Kaplan-Meier) was 8% Ϯ 3% in yr 1, 11% Ϯ 4% in yr 2, and 13% Ϯ 4% in yr 3. Nine of the 12 reinfections occurred during yr 1. Recurrence of duodenal ulcer was detected in five patients (5.2%), all of them during yr 1 of follow-up. Histologically, gastritis scores (according to the Sydney system) improved significantly after eradication. CONCLUSIONS:In a high prevalence setting, H. pylori eradication and early reinfection rates after treatment are similar to rates observed in a low prevalence environment, whereas the late reinfection rate seems to be higher. However, up to 3 yr after treatment, most treated patients are free of H. pylori infection and/or ulcer activity. Even longer follow-up studies are necessary to determine whether specific retreatment policies are necessary to maintain long term eradication in developing countries. (Am J Gastroenterol 2000;95: 50 -56.

show abstract

Section: Discussionsupporting

confidence: 55%

The long-term reinfection rate and the course of duodenal ulcer disease after eradication of Helicobacter pylori in a developing country

Rollan¹

2000

The American Journal of Gastroenterology

View full text Add to dashboard Cite

show abstract

“…This is supported by the high rate of H pylon infection but low ulcer prevalence in a study from Peru where acquisition of the organism is thought to occur early in life. 28 Although the association between gastritis, peptic ulcer, and H pylori is strong, the relationship between H pylon infection and symptoms in those without ulcer is less clear. In the west the association between H pylon and dyspepsia and the effect of suppression or eradication of H pylon on non-ulcer dyspepsia has yielded both negative293 and positive findings.3-33 In this study there was no correlation between symptoms (in patients without an ulcer) and the presence of H pylorn infection.…”

Section: Discussionmentioning

confidence: 99%

Dyspepsia, Helicobacter pylori, and peptic ulcer in a randomly selected population in India.

Katelaris

Tippett

Norbu

et al. 1992

Gut

View full text Add to dashboard Cite

There seems to be a worldwide geographic variation in the prevalence of peptic ulcer disease, although there are few reliable population based studies. This study aimed to determine the prevalence ofpeptic ulcer disease in a community in southern India and to evaluate the relationship between dyspeptic symptoms, Helicobacter pylori infection, gastritis, and peptic ulcer disease. A sample population was selected randomly from a rural monastic settle-.ment in southern India. Subjects were interviewed using a standardised symptom and demography questionnaire then underwent upper endoscopy and antral biopsy for histology and CLO rapid urease test. Altogether 197 subjects from a population of 1499 (13.1%) were studied. All were male monks and ethnically Tibetan. The median age was 28 years (range: 21-81). None smoked or took NSAIDs. The six month period prevalence of dyspeptic symptoms was 68*5%.Current symptoms were present in 58-9% of subjects. Dyspepsia was more common in subjects aged 40 years or younger (p

show abstract

“…Furthermore it has been suggested that the age at which infection is acquired may have a major influence on the natural history of the ill ness. Individuals who arc infected in infancy or early childhood are more prone to develop atrophic gastritis and gastric carcinoma, whilst those infected in later life develop peptic ulcer disease [ 15,16]. These outcomes pre sumably also reflect differences in the pathophysiological mechanisms and host responses to infection.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Helicobacterpylori Infection and Chronic Dyspeptic Symptoms among Immigrants from Developing Countries and People Born in Industrialized Countries

Verdú¹,

Fraser²,

Tiberio³

et al. 1996

Digestion

View full text Add to dashboard Cite

The relationship between Helicobacter pylori infection and chronic dyspepsia is controversial. To determine the effect of H. pylori infection on dyspeptic symptoms, we compared the prevalence of H. pylori infection in immigrants from developing countries and people born in industrialized countries. Upper abdominal symptoms were assessed by a questionnaire and H. pylori infection was determined with a 13C-urea breath test and serology. H. pylori infection was found in 63% of subjects from developing countries and 11% of subjects from industrialized countries. There was no difference in the prevalence of dyspeptic symptoms between the 2 groups. The lack of difference in chronic dyspeptic symptoms between the groups, despite a major difference in the H. pylori prevalence, suggests that H. pylori infection is not a major contributor to chronic dyspepsia.

show abstract

Low Peptic Ulcer and High Gastric Cancer Prevalence in a Developing Country with a High Prevalence of Infection by Helicobacter pylori

Cited by 72 publications

References 0 publications

The long-term reinfection rate and the course of duodenal ulcer disease after eradication of Helicobacter pylori in a developing country

The long-term reinfection rate and the course of duodenal ulcer disease after eradication of Helicobacter pylori in a developing country

Dyspepsia, Helicobacter pylori, and peptic ulcer in a randomly selected population in India.

Prevalence of <i>Helicobacte</i><i>r</i><i>pylor</i><i>i</i> Infection and Chronic Dyspeptic Symptoms among Immigrants from Developing Countries and People Born in Industrialized Countries

Contact Info

Product

Resources

About