Dyspepsia, Helicobacter pylori, and peptic ulcer in a randomly selected population in India.

Katelaris, Peter; Tippett, George; Norbu, Passang; Lowe, David; Brennan, Richard E.; Farthing, M. J. G.

doi:10.1136/gut.33.11.1462

Cited by 77 publications

(52 citation statements)

References 24 publications

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“…In 2004, other authors reported a prevalence of H. pylori infection in 56% of dyspeptic patients from Karachi [43]; however, in early 2000, Taj et al reported seroprevalence of H. pylori in 80% of the cases from the city [27]. Our report and another from Yakoob et al confirm the decreasing trend of H. pylori infection overtime in Karachi, which is comparable to trends seen in other South Asian and European countries [44][45][46]. Interestingly, earlier studies from northern and central parts of Pakistan reported 66% and 84% prevalence rates among dyspeptic patients [25,29], indicating the difference in H. pylori infection in geographic niches and ethnic groups in Pakistan.…”

Section: Discussionsupporting

confidence: 79%

Prevalence, diversity and disease association of Helicobacter pylori in dyspeptic patients from Pakistan

Khan

Farooqui

Raza

et al. 2013

J Infect Dev Ctries

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Introduction: The etiological association of Helicobacter pylori with gastric ulcer (GU), gastric cancer (GC), and duodenal ulcer (DU) is well-known. Understanding the epidemiology of H. pylori facilitates the estimation of disease burden in a certain population. This study presents the diversity of H. pylori genotypes and their association with different clinical outcomes among dyspeptic patients in Pakistan over a period of four years. Methodology: Gastric biopsy samples from a total of 450 dyspeptic individualswere subjected to PCR, genotypingand histology. Results: A total of 201 (45%) cases were found positive for H. pylori. The detection rate was high in GU (91%), DU (86%) and GC (83%) cases compared with those cases who had intact gastric mucosa (18%). Histology revealed the presence of infection in 68% of cases of mild/chronic nonspecific gastritis with others belonging to the GU sequel. cagA gene carriage was observed in 104 (51%) cases or mostly from DU, GU and GC groups, of which 97 were Western type strains while 3 were East-Asian type strains that are rarely observed in South Asia. vacA allelic variant s1am1 was most commonly observed, followed by s1am2, and s1bm1, with direct correlation in diseased cases (gastritis, GU, DU and GC). Prevalent genotypic combinations were s1am1/cagA -in gastritis and s1am1/cagA + in DU, GU, and GC. Conclusions: Our study indicates the predominant circulation of Western type cagA and vacAs1am1 type H. pylori strains in Pakistan.

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Section: Discussionsupporting

confidence: 79%

Prevalence, diversity and disease association of Helicobacter pylori in dyspeptic patients from Pakistan

Khan

Farooqui

Raza

et al. 2013

J Infect Dev Ctries

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“…Colonization rates of its human host depend on socioeconomic, ethnic, geographical, and age-related factors [69,70]. Adults from developing countries demonstrate prevalence rates that approach 80% [71,72], while rates less than 60% are seen in industrialized countries [73,74]. In an adult cohort from the United States, positive H. pylori serology ranged from 16.7% for persons 20-29 years old to 56.9% for persons of age 70 or greater, demonstrating a clear age-related prevalence [75].…”

Section: About H Pylorimentioning

confidence: 99%

Helicobacter pylori eradication: Novel therapy for immune thrombocytopenic purpura? A review of the literature

et al. 2005

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Eradication of Helicobacter pylori (H. pylori ) from the gastric mucosa has been associated with improvement of several systemic diseases, including immune thrombocytopenic purpura (ITP). Over the last 5 years, several studies have reported improved platelet counts in H. pylori-positive ITP patients following standard triple H. pylori eradication therapy. Review of published studies in which eradication of H. pylori has been performed in the ITP population indicates an overall response rate of 52% in 193 subjects in whom H. pylori was eradicated. Cohorts from Japan and Italy report higher response rates. There is no established mechanism to explain how this organism, which does not invade the gastric mucosa, could be implicated in the pathogenesis of this immune-based platelet disorder. Several theories including molecular mimicry, platelet aggregation, and immunomodulatory effects of macrolides have been proposed to explain the platelet response to anti-H. pylori therapy. Large randomized-controlled studies enrolling patients from various ethnic backgrounds will be necessary to determine the response rate and mechanism of response and to gain a better understanding of the pathogenesis of ITP. Am.

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“…A study from Mizoram reported higher rate of infection by H. pylori in stomach cancer patients (Parkin, 2006). The findings in the study shows a decline of about 20% in the prevalence of H. pylori over last 10years (Graham et al, 1991;Gill et al, 1992;Katelaris et al, 1992;Jain et al, 1999;Misra et al, 2007).…”

Section: Discussionmentioning

confidence: 89%

Helicobacter pylori Infection and a P53 Codon 72 Single Nucleotide Polymorphism: a Reason for an Unexplained Asian Enigma

Pandey¹,

Misra²,

Misra³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Aim: P53, the most commonly mutated tumor suppressor gene in all types of human cancer, is involved in cell cycle arrest and control of apoptosis. Although p53 contains several polymorphic sites, the codon 72 polymorphism is by far more common. There are divergent reports but many studies suggest p53 pro/pro SNP may be associated with susceptibility to developing various cancers in different regions of the world. The present study aimed to find any correlation between H. pylori infection and progression of carcinogenesis, by studying apoptosis and the p53 gene in gastric biopsies from north Indian population. Materials and Methods: A total of 921 biopsies were collected and tested for prevalence of H. pylori by rapid urease test (RUT), imprint cytology and histology. Apoptosis was studied by the TUNEL method. Analysis of p53 gene polymorphism at codon 72 was accomplished by PCR using restriction enzyme BstU1. Observation: Out of 921 samples tested 56.7% (543) were H. pylori positive by the three techniques. The mean apoptotic index (AI) in the normal group was 2.12, while gastritis had the maximum 4.24 followed by gastric ulcer 2.28, gastropathy 2.22 and duodenal ulcer 2.08. Mean AI in cases with gastric cancer (1.72) was less than the normal group. The analysis of p53 72 SNP revealed that p53 (Arg/Arg), (Pro /Arg) variant are higher (40.59% & 33.66%) as compared to p53 pro/pro variant (25.74%) inthe healthy population. Conclusions: The North Indian population harbors Arg or Pro/Arg SNP that is capable of withstanding stress conditions; this may be the reason of low incidence of gastric disease in spite of high infection with H. pylori. There was no significant association with H. pylori infection and AI. However, there is increased apoptosis in gastritis which may occur independent of H. pylori or p53 polymorphism.

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Dyspepsia, Helicobacter pylori, and peptic ulcer in a randomly selected population in India.

Cited by 77 publications

References 24 publications

Prevalence, diversity and disease association of Helicobacter pylori in dyspeptic patients from Pakistan

Prevalence, diversity and disease association of Helicobacter pylori in dyspeptic patients from Pakistan

Helicobacter pylori eradication: Novel therapy for immune thrombocytopenic purpura? A review of the literature

Helicobacter pylori Infection and a P53 Codon 72 Single Nucleotide Polymorphism: a Reason for an Unexplained Asian Enigma

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