Low penetrance genetic polymorphisms as potential biomarkers for colorectal cancer predisposition

Tan, Shing Cheng

doi:10.1002/jgm.3010

Cited by 32 publications

(21 citation statements)

References 164 publications

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“…For instance, while He et al 15 demonstrated that the variant allele of MIR499A rs3746444 polymorphism was significantly associated with an increased susceptibility to breast cancer, Morales et al 16 did not find any significant association. One of the major reasons for the inconsistency of study results in genetic association studies is the limited sample size and thus, low statistical power of the individual studies 17,18 . Therefore, in this work, we aimed to pool the study findings via a meta-analysis in order to derive a more precise estimate of the association between MIR499A rs3746444 polymorphism and breast cancer susceptibility.…”

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Association between MIR499A rs3746444 polymorphism and breast cancer susceptibility: a meta-analysis

Tan

Lim

Fang

et al. 2020

Sci Rep

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Numerous studies have investigated the association of MIR499A rs3746444 polymorphism with breast cancer susceptibility, but the results have been inconsistent. In this work, we performed a meta-analysis to obtain a more reliable estimate of the association between the polymorphism and susceptibility to breast cancer. A comprehensive literature search was conducted on PubMed, Scopus, Web of Science (WoS), China National Knowledge Infrastructure (CNKI), VIP and Wanfang databases up to January 2020. A total of 14 studies involving 6,797 cases and 8,534 controls were included for analysis under five genetic models: homozygous (GG vs. AA), heterozygous (AG vs. AA), dominant (AG + GG vs. AA), recessive (GG vs. AA + AG) and allele (G vs. A). A statistically significant association was observed between the polymorphism and an increased breast cancer susceptibility under all genetic models (homozygous, OR = 1.33, 95% CI = 1.03-1.71, P = 0.03; heterozygous, OR = 1.08, 95% ci = 1.00-1.16, P = 0.04; dominant, OR = 1.15, 95% CI = 1.02-1.30; P = 0.03; recessive, OR = 1.35, 95% ci = 1.06-1.72, P = 0.01; allele, OR = 1.12, 95% CI = 1.00-1.26, P = 0.04). Subgroup analysis based on ethnicity suggested that significant association was present only among Asians, but not Caucasians. In conclusion, MIR499A rs3746444 polymorphism was significantly associated with breast cancer susceptibility among Asians, suggesting its potential use as a genetic risk marker in this population.

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Association between MIR499A rs3746444 polymorphism and breast cancer susceptibility: a meta-analysis

Tan

Lim

Fang

et al. 2020

Sci Rep

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“…Given the important role of ERα in BC, its level and structure need to be tightly regulated to ensure an optimal functionality. The level and structure of a protein are known to be influenced by, among others, genetic polymorphisms 59 . For this reason, many genetic association studies have investigated the relationship between ESR1 polymorphisms and BC susceptibility.…”

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confidence: 99%

The rs9340799 polymorphism of the estrogen receptor alpha (ESR1) gene and its association with breast cancer susceptibility

Tan

Low

Hanif

et al. 2021

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The ESR1 rs9340799 polymorphism has been frequently investigated with regard to its association with breast cancer (BC) susceptibility, but the findings have been inconclusive. In this work, we aimed to address the inconsistencies in study findings by performing a systematic review and meta-analysis. Eligible studies were identified from the Web of Science, PubMed, Scopus, China National Knowledge Infrastructure, VIP and Wanfang databases based on the predefined inclusion and exclusion criteria. The pooled odds ratio (OR) was then calculated under five genetic models: homozygous (GG vs. AA), heterozygous (AG vs. AA), dominant (AG + GG vs. AA), recessive (GG vs. AA + AG) and allele (G vs. A). Combined results from 23 studies involving 34,721 subjects indicated a lack of significant association between the polymorphism and BC susceptibility (homozygous model, OR = 1.045, 95% CI 0.887–1.231, P = 0.601; heterozygous model, OR = 0.941, 95% CI 0.861–1.030, P = 0.186; dominant model, OR = 0.957, 95% CI 0.875–1.045, P = 0.327; recessive model, OR = 1.053, 95% CI 0.908–1.222, P = 0.495; allele model, OR = 0.987, 95% CI 0.919–1.059, P = 0.709). Subgroup analyses by ethnicity, menopausal status and study quality also revealed no statistically significant association (P > 0.05). In conclusion, our results showed that the ESR1 rs9340799 polymorphism was not associated with BC susceptibility, suggesting its limited potential as a genetic marker for BC.

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“…In addition, the study by Pietrzyk et al (2017) carried out in Poland with medical faculty students reported that the students had sufficient knowledge about the prevention of CRC. Furthermore, in a study carried out in Malaysia with the general population, it was stated that the majority of the participants had a good level of awareness on the issue (Mohd Suan, Mohammed, & Abu Hassan, 2015;Tan, 2018). It is hypothesised that students with awareness towards approaches for reducing the risk of CRC might develop such healthy lifestyles.…”

Section: Discussionmentioning

confidence: 99%

Awareness of health sciences students about colorectal cancer risk factors

Ustundag

Zengin²,

Andsoy

et al. 2019

Eur J Cancer Care

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Objective This descriptive study was conducted in order to determine the risk factors, symptoms and awareness of health sciences students with regards to colorectal cancer (CRC). Methods This study included 1,028 health science students from two different universities. Data for this study were collected via a questionnaire form that included questions about CRC risk factors, protective approaches and symptoms. Frequencies, percentages and averages of the data were assessed with Kruskal–Wallis and Mann–Whitney U tests. Results The most frequent risk factors of the students (mean age: 21.25 years) were smoking (90.5%), excessive alcohol consumption (87.4%), family history of cancer (84.2%) and obesity (82.6%), while the most common protective approaches were smoking cessation, avoiding alcohol, regular physical activity and a low‐fat diet. There was a significant difference in the CRC awareness of students in terms of gender, the department and grade level at which they were studying, and having a family history of cancer. Conclusion Results of this study revealed that students had a sufficient awareness about risk factors and what they could do to diminish their risk, but their knowledge about CRC symptoms was less than expected. We believe that health sciences students should be given more education on CRC symptoms.

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Low penetrance genetic polymorphisms as potential biomarkers for colorectal cancer predisposition

Cited by 32 publications

References 164 publications

Association between MIR499A rs3746444 polymorphism and breast cancer susceptibility: a meta-analysis

Association between MIR499A rs3746444 polymorphism and breast cancer susceptibility: a meta-analysis

The rs9340799 polymorphism of the estrogen receptor alpha (ESR1) gene and its association with breast cancer susceptibility

Awareness of health sciences students about colorectal cancer risk factors

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