Low Myostatin Serum Levels Are Associated with Poor Outcome in Critically Ill Patients

Wirtz, Theresa H.; Loosen, Sven H.; Buendgens, Lukas; Kurt, Berkan; Jhaisha, Samira Abu; Hohlstein, Philipp; Brozat, Jonathan F.; Weiskirchen, Ralf; Luedde, Tom; Tacke, Frank; Roderburg, Christoph; Koch, Alexander

doi:10.3390/diagnostics10080574

Cited by 11 publications

(17 citation statements)

References 34 publications

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“…Such cross-validation might help to further characterize the usefulness of PLIN2 as an adjunct to currently used biomarkers as the latter still lack in predictive power, specificity and sensitivity when it comes to differentiating the various etiologies of critical illness [70,71]. First, we observed a correlation between PLIN2 and Myostatin, a protein negatively regulating skeletal muscle growth, which was reduced in ICU patients and mechanically ventilated patients, and was also an independent prognostic marker for overall survival [47]. Interestingly, this is consistent with the finding that decreased PLIN2 levels in critically ill patients were associated with severe oxygenation failure.…”

Section: Discussionmentioning

confidence: 82%

“…We performed uni-and multivariable logistic regression analyses to evaluate whether PLIN2 acts as an independent marker for occurrence of sepsis and disease severity (i.e., multiple organ dysfunction (MOD)) (Table 3). To test for independent association of serum PLIN2, we performed various multivariable logistic regression analyses accounting for different parameters that were either associated with PLIN2 serum levels in the literature and/or are associated with sepsis [6,18,32,47,48], i.e., diabetes mellitus (DM) occurrence and age, BMI, norepinephrine demand and established laboratory markers for inflammation, such as C-reactive protein (CRP) and procalcitonin (PCT).…”

Section: Plin2 Levels Were Associated With Organ Failure and Disease Severitymentioning

confidence: 99%

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Serum Perilipin 2 (PLIN2) Predicts Multiple Organ Dysfunction in Critically Ill Patients

et al. 2021

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Perilipin 2 (PLIN2) is a lipid droplet protein with various metabolic functions. However, studies investigating PLIN2 in the context of inflammation, especially in systemic and acute inflammation, are lacking. Hence, we assessed the relevance of serum PLIN2 in critically ill patients. We measured serum PLIN2 serum in 259 critically ill patients (166 with sepsis) upon admission to a medical intensive care unit (ICU) compared to 12 healthy controls. A subset of 36 patients underwent computed tomography to quantify body composition. Compared to controls, serum PLIN2 concentrations were elevated in critically ill patients at ICU admission. Interestingly, PLIN2 independently indicated multiple organ dysfunction (MOD), defined as a SOFA score >9 points, at ICU admission, and was also able to independently predict MOD after 48 h. Moreover, serum PLIN2 levels were associated with severe respiratory failure potentially reflecting a moribund state. However, PLIN2 was neither a predictor of ICU mortality nor did it reflect metabolic dysregulation. Conclusively, the first study assessing serum PLIN2 in critical illness proved that it may assist in risk stratification because it is capable of independently indicating MOD at admission and predicting MOD 48 h after PLIN2 measurement. Further evaluation regarding the underlying mechanisms is warranted.

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Section: Discussionmentioning

confidence: 82%

Section: Plin2 Levels Were Associated With Organ Failure and Disease Severitymentioning

confidence: 99%

Serum Perilipin 2 (PLIN2) Predicts Multiple Organ Dysfunction in Critically Ill Patients

et al. 2021

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“…• Shown to reflect the severity of CHF and predict adverse prognosis in CHF patients [ 120 ]. • Conversely, low myostatin levels are associated with lower survival rates on the ICU, and baseline myostatin serum levels are an independent prognostic marker for overall survival in critically ill patients [ 121 ]. Levels are further significantly reduced in ICU patients requiring mechanical ventilation compared with those not [ 121 ] GDF-8 is a negative regulator of skeletal muscle mass.…”

Section: Importance Of Rapid Testing For Cardiac Markers In Criticall...mentioning

confidence: 99%

“…• Conversely, low myostatin levels are associated with lower survival rates on the ICU, and baseline myostatin serum levels are an independent prognostic marker for overall survival in critically ill patients [ 121 ]. Levels are further significantly reduced in ICU patients requiring mechanical ventilation compared with those not [ 121 ] GDF-8 is a negative regulator of skeletal muscle mass. It is significantly upregulated in muscle wasting conditions independently of cardiac dysfunction.…”

Section: Importance Of Rapid Testing For Cardiac Markers In Criticall...mentioning

confidence: 99%

Electroanalytical point-of-care detection of gold standard and emerging cardiac biomarkers for stratification and monitoring in intensive care medicine - a review

et al. 2022

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Determination of specific cardiac biomarkers (CBs) during the diagnosis and management of adverse cardiovascular events such as acute myocardial infarction (AMI) has become commonplace in emergency department (ED), cardiology and many other ward settings. Cardiac troponins (cTnT and cTnI) and natriuretic peptides (BNP and NT-pro-BNP) are the preferred biomarkers in clinical practice for the diagnostic workup of AMI, acute coronary syndrome (ACS) and other types of myocardial ischaemia and heart failure (HF), while the roles and possible clinical applications of several other potential biomarkers continue to be evaluated and are the subject of several comprehensive reviews. The requirement for rapid, repeated testing of a small number of CBs in ED and cardiology patients has led to the development of point-of-care (PoC) technology to circumvent the need for remote and lengthy testing procedures in the hospital pathology laboratories. Electroanalytical sensing platforms have the potential to meet these requirements. This review aims firstly to reflect on the potential benefits of rapid CB testing in critically ill patients, a very distinct cohort of patients with deranged baseline levels of CBs. We summarise their source and clinical relevance and are the first to report the required analytical ranges for such technology to be of value in this patient cohort. Secondly, we review the current electrochemical approaches, including its sub-variants such as photoelectrochemical and electrochemiluminescence, for the determination of important CBs highlighting the various strategies used, namely the use of micro- and nanomaterials, to maximise the sensitivities and selectivities of such approaches. Finally, we consider the challenges that must be overcome to allow for the commercialisation of this technology and transition into intensive care medicine. Graphical abstract

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“…Low serum myostatin levels can be associated with adverse outcomes. In one study, myostatin levels, upon admission to the intensive care unit, were an independent prognostic biomarker for overall survival, with lower myostatin levels (cut-off value, 16.14 ng/mL) being related to poor survival [ 15 ]. Additionally, myostatin levels were higher in patients with diabetes than those without diabetes, and low myostatin levels were associated with metabolic syndrome [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Correlation of Serum Myostatin Levels with Gait Speed in Kidney Transplantation Recipients

Huang¹,

Tsai

Chen

et al. 2022

IJERPH

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The primary role of myostatin is to negatively regulate skeletal muscle growth. The gait speed is a noninvasive, reliable parameter that predicts cardiovascular risk and mortality. This study evaluated the relationship between serum myostatin concentrations and gait speeds in patients who had undergone kidney transplantation (KT). A total of 84 KT recipients were evaluated. A speed of less than 1.0 m/s was categorized into the low gait speed group. We measured serum myostatin concentrations with a commercial enzyme-linked immunosorbent assay. KT recipients in the low gait speed group had significantly older age, as well as higher body weight, body mass index (BMI), skeletal muscle index, serum triglyceride levels, glucose levels, and blood urea nitrogen levels, lower estimated glomerular filtration rates and serum myostatin levels, a higher percentage of steroid use, and a lower proportion of mycophenolate mofetil use. Multivariable logistic regression analysis revealed that lower myostatin levels and lower frequency of mycophenolate mofetil use were independently associated with low gait speed. In multivariable stepwise linear regression analysis, myostatin levels were positively correlated with gait speeds, and age and BMI were negatively correlated with gait speeds. In the study, serum myostatin levels were significantly lower in the low gait speed group. Subjects in the low gait speed group also had greater BMI and older age.

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Low Myostatin Serum Levels Are Associated with Poor Outcome in Critically Ill Patients

Cited by 11 publications

References 34 publications

Serum Perilipin 2 (PLIN2) Predicts Multiple Organ Dysfunction in Critically Ill Patients

Serum Perilipin 2 (PLIN2) Predicts Multiple Organ Dysfunction in Critically Ill Patients

Electroanalytical point-of-care detection of gold standard and emerging cardiac biomarkers for stratification and monitoring in intensive care medicine - a review

The Correlation of Serum Myostatin Levels with Gait Speed in Kidney Transplantation Recipients

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