Serum Perilipin 2 (PLIN2) Predicts Multiple Organ Dysfunction in Critically Ill Patients

Abstract

Perilipin 2 (PLIN2) is a lipid droplet protein with various metabolic functions. However, studies investigating PLIN2 in the context of inflammation, especially in systemic and acute inflammation, are lacking. Hence, we assessed the relevance of serum PLIN2 in critically ill patients. We measured serum PLIN2 serum in 259 critically ill patients (166 with sepsis) upon admission to a medical intensive care unit (ICU) compared to 12 healthy controls. A subset of 36 patients underwent computed tomography to quantify body composition. Compared to controls, serum PLIN2 concentrations were elevated in critically ill patients at ICU admission. Interestingly, PLIN2 independently indicated multiple organ dysfunction (MOD), defined as a SOFA score >9 points, at ICU admission, and was also able to independently predict MOD after 48 h. Moreover, serum PLIN2 levels were associated with severe respiratory failure potentially reflecting a moribund state. However, PLIN2 was neither a predictor of ICU mortality nor did it reflect metabolic dysregulation. Conclusively, the first study assessing serum PLIN2 in critical illness proved that it may assist in risk stratification because it is capable of independently indicating MOD at admission and predicting MOD 48 h after PLIN2 measurement. Further evaluation regarding the underlying mechanisms is warranted.

Perilipins: A family of five fat‐droplet storing proteins that play a significant role in fat homeostasis

“…In contrast, a study that measured PLIN2 serum levels in 259 critically ill patients found no correlation with obesity, body mass index, total cholesterol, triglycerides, diabetes mellitus, traditional markers of inflammation, such as white blood count and C‐reactive protein. However, it did find a strong negative correlation with lipase and adiponectin as well as increased levels in patients with malignant diseases 45 . This suggests that the health status of individuals may significantly impact the quantities of circulating PLIN2, regardless of the typical markers found in obese individuals or patients with diabetes.…”

“…However, it did find a strong negative correlation with lipase and adiponectin as well as increased levels in patients with malignant diseases. 45 This suggests that the health status of individuals may significantly impact the quantities of circulating PLIN2, regardless of the typical markers found in obese individuals or patients with diabetes.…”

Single-cell transcriptome profiling reveals enriched memory T-cell subpopulations in hypertension

“…PLIN2 intrinsically acts as a perilipin protein, and its expression and phosphorylation are involved in lipolysis, lipid droplet fusion, and signal transduction ( Kaushik and Cuervo, 2015 ; Kaushik and Cuervo, 2016 ). Elevated serum PLIN2 levels have been observed in response to various inflammatory stimuli, including the production of ROS and inflammatory cytokines ( Marschallinger et al, 2020 ; Kurt et al, 2021 ; Zhang et al, 2021 ). CNBP has been identified as a regulator of NF-kB-dependent proinflammatory cytokines.…”

Comprehensive analysis of hypoxia-related gene signature in cervical cancer

“…In different studies, CAVIN3, perilipin 2 (PLIN2), pyruvate dehydrogenase kinase 3 (PDK3), lactate dehydrogenase C (LDHC), and E3 ubiquitin-protein ligase 2 (SIAH2) have been reported to be associated with the occurrence and development of various tumors and poor patient prognosis [32][33][34][35][36]. These markers are expected to be used as markers for targeted tumor therapy and prognostic evaluation.…”