Low muscle mass and mortality risk later in life: A 10-year follow-up study

Pereira, Cristina Camargo; Pagotto, Valéria; Oliveira, César de; Silveira, Érika Aparecida

doi:10.1371/journal.pone.0271579

Cited by 5 publications

(6 citation statements)

References 59 publications

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“…Loss of lean tissue is the body composition hallmark of sarcopenia and is both a cause and marker of frailty (38,39). While a marker of abdominal obesity, ABSI is sensitive to sarcopenia as it reflects fat-free mass as measured by bioelectrical impedance analysis (40).…”

Section: Discussionmentioning

confidence: 99%

The predictive ability of ABSI compared to BMI for mortality and frailty among older adults

Shafran,

Krakauer,

Krakauer

et al. 2024

Front. Nutr.

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IntroductionTo study the utility of A Body Shape Index (ABSI) alongside body mass index (BMI) to predict mortality and frailty in an aging community population.Materials and methodsParticipants (n = 1,580) were drawn from the first Israeli national health and nutrition survey of older adults (“Mabat Zahav”) conducted from 2005 to 2006, constituting adults aged ≥65 years. Socio-demographic, clinical, behavioral, and psychosocial data were collected. Baseline weight, height, and waist circumference (WC) were measured and expressed as the allometric indices BMI (kg/m2) and ABSI, a BMI-independent measure of abdominal obesity [WC/(BMI2/3*m1/2)]. Mortality follow-up lasted through 2019. Frailty was assessed in 2017–2019 by the Fried Biological Phenotype in a sub-cohort of 554 survivors. Cox and logistic regression models assessed associations of BMI and ABSI with mortality and frailty.ResultsAt baseline, mean [SD] age was 74.5 [6.1] years, and 52.4% were women. The correlation between BMI and WC Z scores was 0.71, reduced to −0.11 for BMI and ABSI. Over a median follow-up of 13 years, 757 deaths occurred. The multivariable-adjusted hazard ratios (95% CIs) for mortality per standard deviation increase in BMI and ABSI were 1.07 (0.99;1.17) and 1.13 (1.05;1.21), respectively. Among participants assessed for frailty, 77 (14%) met the frailty criteria. After multivariable adjustment, the odds ratios (95% CIs) for frailty were 0.83 (0.69–1.01) for BMI and 1.55 (1.34–1.79) for ABSI.DiscussionIn a nationwide cohort of older adults, ABSI was independently associated with mortality risk. Furthermore, ABSI, but not BMI, was a strong predictor of frailty.

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Section: Discussionmentioning

confidence: 99%

The predictive ability of ABSI compared to BMI for mortality and frailty among older adults

Shafran,

Krakauer,

Krakauer

et al. 2024

Front. Nutr.

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“…It is well known that low muscle mass is related to an increased risk of physical dependence, diabetes mellitus, osteoporosis, and all-cause mortality [ 5 – 8 ]. As skeletal muscle mass decreases linearly after the age of 30 years [ 2 ], there has been a growing interest in preventive strategies for this harmful condition.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, studies have revealed a considerable prevalence of low muscle mass, ranging from approximately 20% to 40%, within the older Asian population [ 3 , 4 ]. Due to the association between low muscle mass and an elevated risk of physical dependency, osteoporosis, diabetes mellitus, and even all-cause mortality [ 5 – 8 ], there has been a surge of interest in therapeutic and preventive approaches targeting low muscle mass.…”

Section: Introductionmentioning

confidence: 99%

Associations of resistance training levels with low muscle mass: a nationwide cross-sectional study in Korea

Park,

Lim,

Park

2024

Eur Rev Aging Phys Act

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Background Low muscle mass is associated with adverse health outcomes such as functional decline and all-cause mortality. This study investigated the relationship between the risk of low muscle mass and the training period and/or frequency of resistance training (RT). Methods We included 126,339 participants (81,263 women) from nationwide cohorts in Korea. Low muscle mass was defined based on the fat-free mass index. To investigate the presence of an inverse dose–response relationship between RT levels and the risk of low muscle mass, the training period (months) and frequency (per week) of RT were used. Multiple logistic regression models were used to assess the risk of low muscle mass according to the RT levels. Results Prevalence rates for low muscle mass in our study population were 21.27% and 6.92% in men and women, respectively. When compared with not performing RT, performing RT for 3–4 days/week and ≥5 days/week decreased the risk of low muscle mass by 22% and 27%, respectively, and performing RT for 12–23 months and ≥24 months decreased the risk by 19% and 41%, respectively. When simultaneously considering both training period and frequency, performing RT for either 3–4 days/week or ≥5 days/week was significantly related to risk reduction, provided that the training period was at least 1 year. Importantly, performing RT for more than 2 years resulted in an additional risk reduction. However, there was no additional effect of performing RT for ≥5 days/week compared to 3–4 days/week, regardless of whether the RT duration was 1–2 years or more than 2 years. Conclusions Since performing RT for 5 days/week or more did not yield any additional effects on the risk of low muscle mass, performing RT for 3–4 days/week was sufficient to prevent low muscle mass. The effectiveness of this preventive measure can be further enhanced by engaging in long-term RT, specifically for more than 2 years.

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“…Individuals with CeD and NCGWS can have varied clinical presentations based on symptoms of weight loss and degree of malabsorption [ 29 , 30 , 31 ], which can lead to muscle wasting. Low muscle mass has been associated with falls and bone health complications, including fractures [ 32 ] and an increased risk of mortality [ 33 ]. As such, evaluating body composition is an important part of nutrition assessment.…”

Section: Nutritional Assessment Tools To Evaluate Nutritional Statusmentioning

confidence: 99%

Nutritional Considerations in Celiac Disease and Non-Celiac Gluten/Wheat Sensitivity

et al. 2023

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A gluten-free diet (GFD) is the only available treatment for celiac disease (CeD), and it may also improve symptoms in non-celiac gluten/wheat sensitivity (NCGWS). In CeD, gluten triggers an immune reaction leading to enteropathy, malabsorption, and symptoms; in NCGWS, the mechanism leading to symptoms is unknown, and neither wheat nor gluten triggers enteropathy or malabsorption. A strict GFD is, therefore, necessary for CeD, but a gluten-restricted diet (GRD) may suffice to achieve symptom control for NCGWS. Regardless of this distinction, the risk of malnutrition and macro- and micronutrient deficiencies is increased by the adoption of a GFD or GRD. Thus, patients with CeD or NCGWS should undergo nutritional assessment and subsequent monitoring, based on evidence-based tools, under the care of a multidisciplinary team involving physicians and dietitians, for the long-term management of their nutrition. This review gives an overview of available nutrition assessment tools and considerations for the nutritional management of CeD and NCGWS populations.

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Low muscle mass and mortality risk later in life: A 10-year follow-up study

Cited by 5 publications

References 59 publications

The predictive ability of ABSI compared to BMI for mortality and frailty among older adults

The predictive ability of ABSI compared to BMI for mortality and frailty among older adults

Associations of resistance training levels with low muscle mass: a nationwide cross-sectional study in Korea

Nutritional Considerations in Celiac Disease and Non-Celiac Gluten/Wheat Sensitivity

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