Nutritional Considerations in Celiac Disease and Non-Celiac Gluten/Wheat Sensitivity

Abdi, Fardowsa A.; Zuberi, Saania; Blom, Jedid-Jah; Armstrong, David; Sánchez, María Inés Pinto

doi:10.3390/nu15061475

Cited by 14 publications

(12 citation statements)

References 94 publications

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“…However, a FODMAP restriction can decrease gastrointestinal symptoms in individuals. Further research is needed to confirm this finding ( 177 , 178 ).…”

Section: Non-coeliac Gluten Sensitivitymentioning

confidence: 89%

Skin gluten-related disorders: new and old cutaneous manifestations to be considered

et al. 2023

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The term gluten-related disorders (GRD) refer to a spectrum of different clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals, including coeliac disease (CD), wheat allergy and non-celiac gluten sensitivity (NCGS). GRD are characterized by a large variety of clinical presentations with both intestinal and extra-intestinal manifestations. The latter may affect almost every organ of the body, including the skin. Besides the well-known association between CD and dermatitis herpetiformis, considered as the cutaneous specific manifestation of CD, many other muco-cutaneous disorders have been associated to GRD. In this review, we analyzed the main features of dermatological diseases with a proven association with GRD and those that improve after a gluten-free diet, focusing on the newly described cutaneous manifestations associated with NCGS. Our main hypothesis is that a “cutaneous-gluten sensitivity,” as specific cutaneous manifestation of NCGS, may exist and could represent a diagnostic marker of NCGS.

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“…However, a FODMAP restriction can decrease gastrointestinal symptoms in individuals. Further research is needed to confirm this finding ( 177 , 178 ).…”

Section: Non-coeliac Gluten Sensitivitymentioning

confidence: 89%

Skin gluten-related disorders: new and old cutaneous manifestations to be considered

et al. 2023

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“…In recent times, there has been heightened scrutiny of the management approaches for CD and NCGS particularly with a focus on dietary interventions. A GFD is the cornerstone of management for patients with CD and NCGS, as it effectively alleviates symptoms and prevents complications associated with gluten ingestion [ 26 , 27 ]. The mechanism underlying the symptomatic improvement on a GFD differs between CD and NCGS, reflecting the distinct pathophysiological processes involved in each condition [ 1 , 3 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of a Gluten-Free Diet on Whole Gut Transit Time in Celiac Disease (CD) and Non-Celiac Gluten Sensitivity (NCGS) Patients: A Study Using the Wireless Motility Capsule (WMC)

Cobos-Quevedo,

Hernández,

Rivera-Gutiérrez

et al. 2024

JCM

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Background: This study explores the impact of a gluten-free diet (GFD) on regional gastrointestinal (GI) transit times in individuals with celiac disease (CD) and non-celiac gluten sensitivity (NCGS). While a GFD is established for managing CD and wheat allergy, its effects on NCGS remain controversial due to inconclusive evidence. Methods: Utilizing a wireless motility and pH capsule (WMC) to assess regional (measurements of gastric, small bowel, and colonic transit times) and whole gut transit, newly diagnosed CD (n = 12) and NCGS (n = 12) patients underwent evaluations at baseline and 4 weeks after having a GFD. Results: At baseline conditions, individuals diagnosed with CD exhibited prolonged colonic and intestinal transit times when compared to those with NCGS (p < 0.05). Following a 4-week GFD, CD patients experienced significant reductions in both intestinal and colonic transit times, along with enhanced small intestine contractility. NCGS individuals showed improvements in intestinal transit time and contractility with a GFD, although the colon exhibited no discernible effect. The GFD did not significantly impact intragastric, intestinal, or colonic pH. Conclusions: This study, employing WMC for the first time, provides novel insights into the positive effects of a GFD on intestinal and colonic transit, as well as contractility, in CD patients, and to a lesser extent, in those with NCGS.

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“…The phenotype of CD patients is changing with the increasing prevalence of obesity. Patients can be overnourished while still having micronutrient deficiencies [ 44 ].…”

Section: Celiac Diseasementioning

confidence: 99%

Gluten and Wheat in Women’s Health: Beyond the Gut

Manza,

Lungaro,

Costanzini

et al. 2024

Nutrients

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Since the rise of awareness of gluten/wheat-related disorders in the academic and clinical field in the last few decades, misinformation regarding the gluten-free diet (GFD) and its impact on health has been spreading among the general population. Despite the established link between gluten and celiac disease (CD), where a GFD is mandatory to reach clinical and histological remission, things are more complicated when it comes to non-celiac gluten/wheat sensitivity (NCGWS) and other autoimmune/dysimmune disorders. In the last conditions, a beneficial effect of gluten withdrawal has not been properly assessed, but still is often suggested without strong supporting evidence. In this context, women have always been exposed, more than men, to higher social pressure related to nutritional behaviors and greater engagement in controlling body weight. With this narrative review, we aim to summarize current evidence on the adherence to a GFD, with particular attention to the impact on women’s health.

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Nutritional Considerations in Celiac Disease and Non-Celiac Gluten/Wheat Sensitivity

Cited by 14 publications

References 94 publications

Skin gluten-related disorders: new and old cutaneous manifestations to be considered

Skin gluten-related disorders: new and old cutaneous manifestations to be considered

Effect of a Gluten-Free Diet on Whole Gut Transit Time in Celiac Disease (CD) and Non-Celiac Gluten Sensitivity (NCGS) Patients: A Study Using the Wireless Motility Capsule (WMC)

Gluten and Wheat in Women’s Health: Beyond the Gut

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