Low muscle mass and low muscle strength associate with nonalcoholic fatty liver disease

Gan, Da; Wang, Lu; Jia, Menghan; Yuan, Rong; Ma, Yiyun; Zheng, Weifang; Zhao, Xueyin; Yang, Fei; Wang, Tianru; Mu, Yun Ping; Zhu, Shankuan

doi:10.1016/j.clnu.2019.04.023

Cited by 67 publications

(82 citation statements)

References 43 publications

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“…Thus, clinical implications of decreased muscle mass with preserved muscle strength should be clarified in future studies. On the other hand, in NAFLD patients, GS is shown to correlate with steatosis grade [6,7,8]. Although investigation of the impact of GS on steatosis in NAFLD patients is beyond the scope of our analysis, to confirm these in Japanese NAFLD patients may be essential.…”

Section: Discussionmentioning

confidence: 99%

“…In our previous investigation, we reported that GS had a strong influence especially in the physiological domains in the 36-Item Short-Form Health Survey in patients with CLDs [4]. We also demonstrated that muscle strength decline was closely associated with sleep disorder in patients with CLDs [5], while non-alcoholic fatty liver disease (NAFLD) is reported to be linked to muscular impairment in elderly adults [6,7,8]. Lee et al reported that there were linear decreases in the NAFLD index across incremental GS values [8].…”

Section: Introductionmentioning

confidence: 99%

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Significant Correlation Between Grip Strength and m2bpgi in Patients with Chronic Liver Diseases

Nishikawa

Enomoto

Iwata

et al. 2019

JCM

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We sought to compare the impact upon grip strength (GS) between the Mac-2 binding protein glycosylation isomer (M2BPGi) and the Fibrosis-4 (FIB4) index in chronic liver disease (CLD) patients (n = 376: 171 males and 205 females, and 137 liver cirrhosis (LC) cases (36.4%)). Factors linked to the low GS (<26 kg in male and <18 kg in female) were also investigated using univariate and multivariate analyses. The median GS in males was 35.5 kg, while that in females was 21.1 kg. The median M2BPGi was 1.11 cutoff index, whereas the median FIB4 index was 2.069. In both male (P < 0.0001) and female (P = 0.0001), GS in LC patients was significantly lower than that in non-LC patients. In males, M2BPGi (r = −0.4611, P < 0.0001) and the FIB4 index (r = −0.4556, P < 0.0001) significantly correlated with GS. Similarly, in females, M2BPGi (r = −0.33326, P < 0.0001) and our FIB4 index (r = −0.26388, P = 0.0001) also significantly correlated with GS. In the multivariate analyses of factors linked to the low GS, independent factors were: M2BPGi (P = 0.0003) and skeletal muscle index (P = 0.0007) in males, and age (P < 0.0001) and serum albumin level (P = 0.0484) in females. In conclusion, liver fibrosis markers were well-correlated with GS in CLD patients. In particular, M2BPGi can be helpful for predicting the low GS in male patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Significant Correlation Between Grip Strength and m2bpgi in Patients with Chronic Liver Diseases

Nishikawa

Enomoto

Iwata

et al. 2019

JCM

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“…This association was even more robust with sarcopenia (OR=3.91) and sarcopenic obesity (OR=10.42 when defined by BMI and OR=11.64 when defined by waist circumference), indicating that the concurrence of sarcopenia and obesity represents an exceptionally high risk of NAFLD. 47 Clinical evidence for the link between skeletal muscle dysfunction and NAFLD is not confined to the Asia-Pacific region. SMI defined sarcopenia based on BIA (# 37 in men and # 28 in women) in a retrospective study of 225 Italian adults with biopsy-proven NASH, and its prevalence increased with the severity of liver fibrosis from 20.4% (# F2) to 48.3% ($ F3).…”

Section: Clinical Evidence Of Skeletal Muscle Dysfunction In Nafldmentioning

confidence: 99%

Skeletal Muscle Dysfunction in the Development and Progression of Nonalcoholic Fatty Liver Disease

Altajar¹,

Baffy²

2020

Journal of Clinical and Translational Hepatology

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The association between the pathogenesis and natural course of nonalcoholic fatty liver disease (NAFLD) and skeletal muscle dysfunction is increasingly recognized. These obesity-associated disorders originate primarily from sustained caloric excess, gradually disrupting cellular and molecular mechanisms of the adipose-muscle-liver axis resulting in end-stage tissue injury exemplified by cirrhosis and sarcopenia. These major clinical phenotypes develop through complex organ-tissue interactions from the earliest stages of NAFLD. While the role of adipose tissue expansion and remodeling is well established in the development of NAFLD, less is known about the specific interplay between skeletal muscle and the liver in this process. Here, the relationship between skeletal muscle and liver in various stages of NAFLD progression is reviewed. Current knowledge of the pathophysiology is summarized with the goal of better understanding the natural history, risk stratification, and management of NAFLD.

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“…Adjusted grip strength (AGS) was calculated as HGS value divided by body weight × 100 [35] for muscle strength. The cutoff points for low muscle mass and low muscle strength were 28.64% and 51.26% in men and 24.12% and 35.38% in women [36]. Having both low muscle mass and low muscle strength was defined as sarcopenia [36].…”

Section: Definition Of Sarcopeniamentioning

confidence: 99%

“…The cutoff points for low muscle mass and low muscle strength were 28.64% and 51.26% in men and 24.12% and 35.38% in women [36]. Having both low muscle mass and low muscle strength was defined as sarcopenia [36].…”

Section: Definition Of Sarcopeniamentioning

confidence: 99%

Habitual Miso (Fermented Soybean Paste) Consumption Is Associated with a Low Prevalence of Sarcopenia in Patients with Type 2 Diabetes: A Cross-Sectional Study

et al. 2020

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Insulin resistance is a risk of sarcopenia, and the presence of sarcopenia is high in patients with type 2 diabetes (T2DM). It has been reported that habitual miso soup consumption was associated with lower insulin resistance. However, the association between habitual miso consumption and the presence of sarcopenia in patients with T2DM, especially sex difference, was unclear. In this cross-sectional study, 192 men and 159 women with T2DM were included. Habitual miso consumption was defined as consuming miso soup regularly. Having both low skeletal muscle mass index (<28.64% for men, <24.12% for women) and low adjusted hand grip strength (<51.26% for men, <35.38% for women) was defined as sarcopenia. The proportions of sarcopenia were 8.7% in men and 22.6% in women. The proportions of habitual miso consumption were 88.0% in men and 83.6% in women. Among women, the presence of sarcopenia was lower in the group with habitual miso consumption (18.8% versus 42.3%, p = 0.018); however, there was no association between habitual miso consumption and the presence of sarcopenia in men. Habitual miso consumption was negatively associated with the presence of sarcopenia in women (adjusted odds ratio (OR), 0.20 (95% confidence interval (CI): 0.06–0.62), p = 0.005) but not in men. This study indicated that habitual miso consumption was associated with the presence of sarcopenia in women but not in men.

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Low muscle mass and low muscle strength associate with nonalcoholic fatty liver disease

Cited by 67 publications

References 43 publications

Significant Correlation Between Grip Strength and m2bpgi in Patients with Chronic Liver Diseases

Significant Correlation Between Grip Strength and m2bpgi in Patients with Chronic Liver Diseases

Skeletal Muscle Dysfunction in the Development and Progression of Nonalcoholic Fatty Liver Disease

Habitual Miso (Fermented Soybean Paste) Consumption Is Associated with a Low Prevalence of Sarcopenia in Patients with Type 2 Diabetes: A Cross-Sectional Study

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