Low‐molecular‐weight heparin (enoxaparin) in the treatment of lichen planus

Ferahbaş, Ayten; Ukşal, Ümit; Kutlugun, Caner; Kontaş, Olgun

doi:10.1046/j.1468-3083.2003.00732.x

Cited by 11 publications

(9 citation statements)

References 5 publications

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“…Our results are similar with these study results. There are two studies that failed to demonstrate a beneficial effect of enoxaparin in the treatment of LP (18,19).…”

Section: Discussionmentioning

confidence: 99%

The management of lichen planus with low-molecular-weight heparin (enoxaparin)

Akdeniz

Harman

Atmaca

et al. 2005

International Journal of Clinical Practice

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The aim of this study is to evaluate the efficiency of low-dose, low-molecular-weight heparin (enoxaparin) in the treatment of lichen planus (LP). Twenty-four patients clinically and histopathologically diagnosed as LP with intense pruritus were treated with 3 mg of enoxaparin (Clexane), subcutaneously once a week for 4-14 weeks. Complete remission was observed in 20 of 24 patients (83%) who had widespread cutaneous involvement, but no or minimal effect was observed in four of 24 patients, three of whom had chronic hypertrophic LP. Low-dose enoxaparin was observed to be effective in the treatment of LP without any side-effects. Enoxaparin may be an effective and simple alternative therapy for LP.

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“…Our results are similar with these study results. There are two studies that failed to demonstrate a beneficial effect of enoxaparin in the treatment of LP (18,19).…”

Section: Discussionmentioning

confidence: 99%

The management of lichen planus with low-molecular-weight heparin (enoxaparin)

Akdeniz

Harman

Atmaca

et al. 2005

International Journal of Clinical Practice

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“…1,2,6 In the present study we investigated the effects in vitro and in vivo of the heparanase inhibitor, heparin, on the expression of T lymphocyte heparanase and on the ability of T lymphocytes to mediate a delayed-type hypersensitivity (DTH) reaction. 6 The low-molecular-weight heparin reduces translocation of tumor necrosis factor alfa (TNF-a), interleukin (IL)-8, IL-6, IL-1B and nuclear factor (NF) kappa B (kB) which are caused by lipopolysaccharides distinctly.…”

Section: 3mentioning

confidence: 99%

“…They observed that enoxaparin is non-effective except reducing pruritus. 2 At the other hand, studies have shown that on the treatment of lichen planus patients, enoxaparin treatment is a basic and effective method.…”

Section: 3mentioning

confidence: 99%

“…There are various clinical types of Lichen Planus and the course of disease is unpredictable. 2 The Lichen Planus is characterized by the interface dermatitis which is occurred intensely infiltration of lymphocytes along dermal-epidermal junction and vacuolar degeneration and destruction of keratinocytes on stratum basale. 1 Apoptosis of T-lymphocytes and keratinocytes which are contained in dermal infiltrate cause the destruction of epidermis.…”

Section: Introductionmentioning

confidence: 99%

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The effectiveness of treatment with enoxaparin in lichen planus

Uçmak

Balci²,

Harman³

2012

J Clin Exp Invest

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ÖZETAmaç: Heparin analoglarının düşük dozlarının antiproliferatif ve immünmodülatör etkilerinin olduğu bilinmektedir. Bu çalışmanın amacı; liken planusta düşük doz enoxaparinin etkinliğini değerlendirmektir. Gereç ve yöntem:Liken planus tanısı alan 21 hasta 12 hafta boyunca tedavi edildi. Hastalara her hafta 3 mg enoxaparin subkutan enjeksiyonla yapıldı. Etki ve güven-lik verileri kaydedildi. Bulgular:Tam iyileşme hastaların 15' inde (%71), belirgin düzelme 4' ünde (%19) tespit edildi. Hastaların 2'sinde (%9) tedaviye yanıt alınmadı. Tedavi sonucunda en iyi yanıt, liken planusun akut generalize tipinde görüldü.Sonuç: Sonuç olarak enoxaparin tedavisinin liken planusta etkili bir tedavi seçeneği olabileceği kanaatine varıldı.Anahtar kelimeler: Liken planus, enoxaparin, tedavi ABSTRACT Objectives: As it is known, the low doses of Heparin's analogues have the antiproliferative and immunomodulator activities. This research aims to evaluate the activity of enoxaparin by using the low doses. Materials and methods:21 patients with lichen planus diagnosis have been cured within 12 weeks. 3 mg of enoxaparin has been used for subcutaneus injection to all of patients weekly. The efficient and reliable data has been saved. Results:The perfect recovery has been observed 15 (71%) of 21 patients, the distinct recovery has been observed 4 (19%) of 21 patients. The treatment has not given response on 2 (9%) of 21 patients. The best score has been received on acute generalized type of Lichen Planus. Conclusions:As the result; it has been reported that enoxaparin treatment can be an effective choice in Lichen Planus medication. J Clin Exp Invest 2011; 3(2): 172-173

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“…In contrast, due to a lack of controlled clinical trials, generalized eruptions or more severe types of cutaneous LP are still treated with a broad spectrum of various systemic agents initially comprised of acitretin and oral corticosteroids (8). Furthermore, immunosuppressants [e.g., mycophenolate mofetil (9), azathioprine (10), methothrexate (11)], PUVA (12), low‐molecular heparin (13), dapsone (14), and T‐cell receptor mimic peptides (15) have been successfully used for adults. Still, it is important to keep in mind that the disease can show spontaneous remission.…”

mentioning

confidence: 99%

Eruptive Lichen Planus in a Child

Ott

Frank

Poblete‐Gutiérrez

2007

Pediatric Dermatology

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Lichen planus is a chronic inflammatory disease of the skin and mucous membranes. Typically, skin lesions include violaceous, polygonal, flat papules and plaques. However, the clinical presentation of lichen planus can be heterogeneous and show divergent degrees of cutaneous and mucous manifestation. The disease usually affects adults and is only rarely encountered in children. Here, we present a 7-year-old boy who rapidly developed itching skin lesions on the extremities and trunk. He had no history of concomitant drug intake, infection or vaccination. Clinical examination of the skin found multiple white-grayish papules and plaques whereas the scalp, mucous membranes and nails were not affected. Histologic examination showed typical findings of lichen planus. We initiated topical corticosteroid therapy, which resulted in healing of the skin lesions within 4 weeks. To our knowledge this is the first instance of exanthematous lichen planus in childhood successfully treated with topical corticosteroid ointment alone. Thus, even generalized lichen planus lesions can be effectively cleared without systemic therapies, which can be potentially associated with serious side effects, especially in children.

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Low‐molecular‐weight heparin (enoxaparin) in the treatment of lichen planus

Cited by 11 publications

References 5 publications

The management of lichen planus with low-molecular-weight heparin (enoxaparin)

The management of lichen planus with low-molecular-weight heparin (enoxaparin)

The effectiveness of treatment with enoxaparin in lichen planus

Eruptive Lichen Planus in a Child

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