The management of lichen planus with low-molecular-weight heparin (enoxaparin)

Abstract

The aim of this study is to evaluate the efficiency of low-dose, low-molecular-weight heparin (enoxaparin) in the treatment of lichen planus (LP). Twenty-four patients clinically and histopathologically diagnosed as LP with intense pruritus were treated with 3 mg of enoxaparin (Clexane), subcutaneously once a week for 4-14 weeks. Complete remission was observed in 20 of 24 patients (83%) who had widespread cutaneous involvement, but no or minimal effect was observed in four of 24 patients, three of whom had chronic hypertrophic LP. Low-dose enoxaparin was observed to be effective in the treatment of LP without any side-effects. Enoxaparin may be an effective and simple alternative therapy for LP.

Efficacy of Low Dose Low Molecular Weight Heparin in the Treatment of Cutaneous Lichen Planus

“…The mean age of the patients was 36±6.6 years and their age ranged from 20 to 50 years. Among the patients, highest percentage of patients, 21(56.8%) were in between 30 to 40 years of age, followed by 10(27%) were 40 to 50 years old and 6 (16.2%) were in between the 20-30 years of age, similar to the study finding of Kanwar It was seen that 29(78.4%) had no side effect and 8(21.6%) had side effects of drugs, not similar to the study finding of Akdeniz et al, where twenty four patients were treated by low molecular weight heparin and complete remission was observed without any side effect 15 . Similar study finding was also observed by Pacheco et al when seven patients of cutaneous lichen planus were treated with low-molecular weight heparin where marked improvement was seen without any side effect 17 .…”

Use of enoxaparin to diminish the incidence of vascular access stenosis/thrombosis in chronic hemodialysis patients

“…Complete remission was observed in 20 of the 24 patients (83%) who had widespread cutaneous involvement [15].…”

Penile Dermatosen

“…Immunmodulatorische Therapieversuche mittels Calcineurinantagonisten und niedermolekularem Heparin sind erfolgversprechend [1]. Bei fulminanten Krankheitsverläufen ist eine systemische Retinoid-(Acitretin, Isotretinoin) oder Ciclosporin-Therapie zu erwägen [3,34,46,51].…”