Low maternal leptin levels in preeclamptic women with  fetal growth restriction

Sumawan, Herman; Purwara, Benny Hasan; Krisnadi, Sofie Rifayani

doi:10.4236/ojog.2013.37096

Cited by 4 publications

(4 citation statements)

References 28 publications

(30 reference statements)

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“…As described in Table 2 with the study conducted by Sumawan, et al (19), there was no signiicant correlation between maternal leptin level and birth weight. Factors that inluenced this result were the difference in the number, characteristic, selection criteria for subjects and BMI.…”

Section: The Difference In Maternal Serum Leptin Level Between Preeclsupporting

confidence: 50%

“…The results of this study showed that maternal serum leptin level in preeclampsia increased signiicantly as compared to that in normal pregnancy which is in accordance with previous conducted studies. (19) Some other studies, however, showed different results in which there was a decrease or constant leptin level in preeclampsia. (21) Several other studies showed similar results with this study such as those conducted by Mise,et al (20) and Khosrowbeygi,et al (22), where they found a signiicant increase in maternal serum leptin level in preeclamptic women as compared to normal pregnant women.…”

Section: The Difference In Maternal Serum Leptin Level Between Preeclmentioning

confidence: 97%

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Differences in Maternal Leptin Serum Levels between Normal Pregnancy and Preeclampsia

2015

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BACKGROUND: Maternal circulating leptin, placental leptin gene expression and protein levels are increased in preeclampsia as compared with those in normal pregnancy. Increased serum leptin levels in preeclampsia which correspond with increased gestational age can be used independently or with other parameters as a marker for the severity of preeclampsia. The advantages of this examination in identifying preeclampsia severity are its simplicity, fast result, low cost and applicability.METHODS: A cross-sectional study was conducted in delivery room, polyclinic of Dr. M. Djamil Hospital, and Biomedical Laboratories of Medical Faculty of Andalas University from December 2013 to April 2014. The samples were collected from 68 women with singleton pregnancy in their third trimester (>28 weeks) presenting to the polyclinic and the delivery room of Dr. M. Djamil hospital. Differences in maternal serum leptin between preeclampsia and normal pregnancy were determined using t-test and Wilcoxon test for data with and without normal distribution, respectively, where p<0.05 indicating a significant results.RESULTS: The mean maternal serum leptin levels in normal pregnancy and preeclampsia were 1588.7964 ± 8.01074 ng/mL and 1608.1725 ± 6.69579 ng/mL, respectively. Thus, there is a statistically significant difference in mean maternal serum leptin levels between the normal pregnancy and preeclampsia (p<0.05).CONCLUSION: There are significant differences in maternal serum leptin levels between women with normal pregnancy and preeclampsia.KEYWORDS: leptin, preeclampsia, pregnancy

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Section: The Difference In Maternal Serum Leptin Level Between Preeclsupporting

confidence: 50%

Section: The Difference In Maternal Serum Leptin Level Between Preeclmentioning

confidence: 97%

Differences in Maternal Leptin Serum Levels between Normal Pregnancy and Preeclampsia

2015

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“…1 Prevalensi PJT di dunia adalah enam kali lebih tinggi di negara berkembang, 75% di antaranya berada di Asia, Afrika (20%) dan Amerika latin (5%). Di Indonesia, prevalensi rata-rata dari 4 pusat kesehatan ibu dan anak selama periode dari 2004 ke 2005 adalah 4,4%, dengan prevalensi tertinggi (6,44%) dilaporkan di RS Sardjito Yogyakarta 2,3 Salah satu teori utama mengenai penyebab terjadinya pertumbuhan janin terhambat yaitu hasil interaksi plasenta dengan sistem imun maternal, dimana selama kehamilan mengalami kontak langsung dengan fetus yang semi-alogenik. Sel jenis khusus yaitu trofoblas, berasal dari fetus, menginvasi uterus dan kontak langsung dengan sistem imun maternal.…”

Section: Pendahuluanunclassified

The Difference Human Leukocyte Antigen-E (Hla-E) Expression and Natural Killer Cells (Nk Cells) in Trophoblast Between Intrauterine Growth Restriction (Iugr) and Normal Pregnancy

Soetrisno

Sulistyowati

Respati

et al. 2018

NMSJ

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Background: Intrauterine growth restriction (IUGR) is still a major cause of perinatal morbidity and mortality. IUGR incidence ranged from 4.4 to 6.44% of pregnant women. Human Leukocyte Antigen - E and NK cells are thought to play an important role towards the process of IUGR.Objective: To determine aetiopathogenesis HLA-E expression and NK Cell in IUGR.Methods: An analytical observational study conducted through a cross-sectional approach. The research was conducted on March-October 2015 at the Obstetrics and Gynecology Department, Dr. Moewardi Hospital Surakarta and at of Laboratory of Pathology, Faculty of Medicine, Universitas Sebelas Maret Surakarta. Subjects who meet the inclusion and exclusion criteria consisted of 20 patients with IUGR and 20 normal pregnant patient. The researcher examined HLA-E Expression and NK cells in trophoblast using immunohistochemical method and statistical analysis using t test.Results: The average HLA-E expression in the trophoblast in IUGR group 17.80 ± 5.55, compared with normal pregnancy 66.23 ± 19.83, p value = 0.0001 (p <0.05). The average expression of NK cells in trophoblast in IUGR group 137.71 ± 28.09 compared with normal pregnancy 31.75 ± 14.77, p value = 0.0001 (p <0.05).Conclusion: HLA-E expression in normal pregnancy trophoblast is higher than pregnancies with IUGR. Expression of NK cells in pregnancy with IUGR is higher compared with normal pregnancy.

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“…A number of studies have reported that serum leptin plays a role in the pathogenesis of PE, so that an increase in leptin levels may help prediction of disease and a marker of the severity of PE. Serum Leptin is also known to play a significant role as a biomarker of EOPE and LOPE in relation to the severity of the disease, body mass index (BMI), IUGR and LBW [16]- [18]. Low birth weight and BMI are known to correlate with risk factors for cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

The Correlation between Mothers with Low Birth Weight History and Body Mass Index Leptin Levels, and Preeclampsia

Aziz¹,

Mose²,

Deborah³

2015

OALib

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Preeclampsia (PE) is one of the complications of pregnancythat significantly increases maternal and fetal mortality and morbidity. Mothers who were born as low birth weight (LBW) babies have risks for PE that are 2 -3 times higher than maternal birth weight ≥ 2500 g. LBW history of the mother is also correlates with the incidence of metabolic syndrome later in life including incresed of body mass index (BMI), hyperlipidemia, hypertension, stroke type 2 diabetes and cardiovascular accident (CVA). This study aimed at assessing the correlation between the incidence of LBW history of the mother with PE, BMI and leptin levels. This study was a retrospective study of maternal LBW history with case control design as well as cross-sectional design to search the correlation between BMI and leptin levels with the incidence of PE. This study was conducted from December 2014 through February 2015 in Hasan Sadikin Hospital Bandung. Data were analyzed using Spearman Rank and Chi-Square, and the significant difference was determined as α < 0.05. The results showed that maternal LBW history correlated with an increased in systolic (r = −0.417; p = 0.017) and diastolic (r = −0.498; p = 0.004) blood pressure but did not correlated with the incidence of PE (r = 0.333; p = 0.127). The incidence of maternal history of LBW was higher in cases of PE (p = 0.033). There was a correlation between LBW history and early onset preeclampsia (EOPE) and late onset preeclampsia (LOPE) (r = 0.500; p = 0.048). There was no correlation between LBW history of BMI (r = −0.040; p = 0.830) and levels of leptin (r = −0.157; p = 0.390). There was a correlation of BMI and leptin levels (r = 0.664; p = 0.0001) Maternal LBW history was correlated with increased incidence of systolic and diastolic blood pressure and the incidence of EOPE and LOPE.

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Low maternal leptin levels in preeclamptic women with fetal growth restriction

Cited by 4 publications

References 28 publications

Differences in Maternal Leptin Serum Levels between Normal Pregnancy and Preeclampsia

Differences in Maternal Leptin Serum Levels between Normal Pregnancy and Preeclampsia

The Difference Human Leukocyte Antigen-E (Hla-E) Expression and Natural Killer Cells (Nk Cells) in Trophoblast Between Intrauterine Growth Restriction (Iugr) and Normal Pregnancy

The Correlation between Mothers with Low Birth Weight History and Body Mass Index Leptin Levels, and Preeclampsia

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