Low levels of vitamin D in North Indian children with newly diagnosed type 1 diabetes

Borkar, Vibhor; Devidayal,; Verma, Savita; Bhalla, AK

doi:10.1111/j.1399-5448.2009.00589.x

Cited by 103 publications

(93 citation statements)

References 34 publications

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“…This is consistent with two previous case-control studies of serum 25(OH)D [8,9], but not a third [10]. An inverse association between serum 25(OH)D and risk of insulin-requiring diabetes was present in the same direction and was statistically significant in all race groups.…”

Section: Discussionsupporting

confidence: 81%

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Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case–control study

et al. 2012

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Aims/hypothesis Low serum 25-hydroxyvitamin D [25 (OH)D] concentration may increase risk of insulinrequiring diabetes.Methods A nested case-control study was performed using serum collected during 2002-2008 from military service members. One thousand subjects subsequently developed insulin-requiring diabetes. A healthy control was individually matched to each case on blood-draw date (±2 days), age (±3 months), length of service (±30 days) and sex. The median elapsed time between serum collection and first diagnosis of diabetes was 1 year (range 1 month to 10 years). Statistical analysis used matched pairs and conditional logistic regression. Results ORs for insulin-requiring diabetes by quintile of serum 25(OH)D, from lowest to highest, were 3.5 (95% CI 2.0, 6.0), 2.5 (1.5, 4.2), 0.8 (0.4, 1.4), 1.1 (0.6, 2.8) and 1.0 (reference) (p trend <0.001). The quintiles (based on fifths using serum 25(OH)D concentration in the controls) of serum 25(OH)D in nmol/l, were <43 (median 28), 43-59 (median 52), 60-77 (median 70), 78-99 (median 88) and ≥100 (median 128). Conclusions/interpretation Individuals with lower serum 25(OH)D concentrations had higher risk of insulinrequiring diabetes than those with higher concentrations. A 3.5-fold lower risk was associated with a serum 25 (OH)D concentration ≥60 nmol/l.

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Section: Discussionsupporting

confidence: 81%

“…These studies depended on self-reported questionnaires, which may have limited their validity. Two ordinary case-control studies found that serum 25(OH)D was inversely associated with risk of insulin-requiring diabetes [8,9], but a third study found no association [10].…”

Section: Introductionmentioning

confidence: 99%

Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case–control study

et al. 2012

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“…7,8 Shellhaas et al demonstrated female gender to be significantly associated with vitamin D deficiency in their study on epileptic children which was attributed to biological/ behavioral differences. 4 Vitamin D levels decreased progressively with age (p=0.034) in our data, a finding not studied in many of the Indian studies. A study done by Absoud and et al found that vitamin D levels decreased with age in both sexes and confirmed a previously under-recognized risk of VDI in adolescents.…”

Section: Discussionsupporting

confidence: 66%

“…In our study 89.1% of children had vitamin D levels less than 30 ng/ml. In this category about 10.9% were severely deficient (SD), 70.8% were deficient (D) and 7.4% were insufficient (I) in vitamin D. A study by Shellhaas 4 showed only 25% of children to have vitamin D levels in sufficient range in children with epilepsy. Our study revealed a prevalence of 89% which may be higher as compared to studies on neurological illnesses internationally.…”

Section: Discussionmentioning

confidence: 99%

Incidence of vitamin D deficiency in pediatric neurology outpatient department of a tertiary care hospital

Karnavat

Hegde

Nabi

2018

Int J Community Med Public Health

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Background: Pediatric neurology outpatient populations are a vulnerable subgroup for vitamin D deficiency. The aim was to study the incidence of vitamin D deficiency in pediatric neurology patients by studying relevant biochemical profile and to assess the contributory factors for the same.Methods: A hospital based cross sectional study was conducted at a tertiary care setup in Mumbai between 2011 and 2012. A total of 284 children aged 0.5-18 years, attending pediatric neurology OPD were enrolled. Statistical analysis was carried out with SPSS version 17.0 and included descriptive statistics; Chi squared and unpaired t-tests to investigate significance of proposed predictors for vitamin D status.Results: 89.1% of the children were deficient in vitamin D levels (≤30 ng/ml); out of these 11% were severely deficient. Factors significantly associated with vitamin D deficiency were increasing age (p=0.034), absence of intake of calcium supplements (p=0.00) and upper socio-economic class (p=0.001). Low serum calcium levels (p=0.01) and high PTH levels (p=0.00) were associated significantly. Prevalence was similar in children with higher BMI as compared to lower BMI. Duration of AEDs rather than number of drugs was more associated with deficiency.Conclusions: A high prevalence of vitamin D inadequacy in noted in pediatric neurology patients.

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“…Prevalence varied from as high as 90.60% with a vitamin D cutoff value of < 30 ng/ mL in Qatar (6), to as low as 15% with a vitamin D cutoff value of < 20 ng/mL at Joslin's diabetes center (9), and intermediate prevalence of 54% with a vitamin D cutoff value of < 32 ng/mL in DIASS study (8). In one north Indian study, 58% children with T1DM aged between 6 and 12 year were vitamin D-deficient as compared with only 32% in the control group (25). In our study 25(OH)D was significantly lower (mean ±SD of 7.88 ± 1.20 ng/mL) in patients, compared with 16.64 ± 7.83 ng/mL in the controls.…”

Section: Discussionmentioning

confidence: 99%

High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India

Daga

Laway

Shah

et al. 2012

Arq Bras Endocrinol Metab

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OBJECTIVES: Vitamin D deficiency is common at all ages, and low levels of vitamin D have been associated with high incidence of type 1 diabetes. Similar results are not consistent for type 2 diabetes. The aim of the present study was to estimate vitamin D status in newly detected youth-onset diabetes in north India. SUBJECTS AND METHODS: This was a prospective case control study at a tertiary care hospital in north India. Seventy two newly detected youth-onset diabetes subjects (age < 25 years), and 41 age- and gender-matched healthy controls were studied. In addition to basic information and management regarding their diabetes, metabolic parameters and serum 25(OH)D were measured in both the groups. RESULTS: Vitamin D deficiency was seen in 91.1% of the subjects with diabetes, and 58.5% of the healthy controls. Mean ±SD 25(OH)D was significantly low, 7.88 ± 1.20 ng/mL in subjects with diabetes against 16.64 ± 7.83 ng/mL in controls. Sixty percent of cases had severe Vitamin D deficiency compared with 8.3% in controls. Levels of vitamin D did not correlate with clinical parameters, such as gender, body mass index; or with biochemical parameters, such as serum calcium, phosphorus, alkaline phosphatase, fasting plasma glucose, and HbA1C. CONCLUSION: Vitamin D deficiency is common in people with youth-onset diabetes.

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Low levels of vitamin D in North Indian children with newly diagnosed type 1 diabetes

Abstract: These results suggest that vitamin D levels are low at the onset of T1D, and they strongly support the need for further clinical studies to prospectively evaluate the effect of vitamin D supplementation on T1D rates in this patient population.

Cited by 103 publications

References 34 publications

Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case–control study

Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case–control study

Incidence of vitamin D deficiency in pediatric neurology outpatient department of a tertiary care hospital

High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India

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