Low levels of plasma omega 3-polyunsaturated fatty acids are associated with cerebral small vessel diseases in acute ischemic stroke patients

Song, Tae Jin; Chang, Yoonkyung; Shin, Min Jeong; Heo, Ji Hoe; Kim, Yong Jae

doi:10.1016/j.nutres.2015.04.008

Cited by 35 publications

(27 citation statements)

References 35 publications

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“…The CMBs were identified as punctate hypointense lesions <10 mm in size on GRE images [14]. The PVSs were defined as punctate or linear hyperintense lesions on T2-weighted images in the basal ganglia and <3 mm in size [12]. Subjects were coded with the following grades: 0 = no PVSs, WMHs, high-grade PVSs, and ALIs, as outlined previously [15].…”

Section: Mri Protocol Definition Of Small Vessel Diseases and Vasculmentioning

confidence: 99%

Moderate-to-severe obstructive sleep apnea is associated with cerebral small vessel disease

et al. 2017

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Section: Mri Protocol Definition Of Small Vessel Diseases and Vasculmentioning

confidence: 99%

Moderate-to-severe obstructive sleep apnea is associated with cerebral small vessel disease

et al. 2017

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“…Furthermore, disease of cerebral small vessel (SVDs) is associated with stroke or diminished cognitive dysfunction. A study of 220 patients with cerebral infarction indicated that reduction of the percentage EPA, DHA, and n-3-PUFAs was related to the presence of cerebral micro-bleeds, high-grade white matter changes, and high-grade perivascular spaces, but not asymptomatic lacunar infarctions [108]. In addition, SVD scores were negatively correlated with the proportion of EPA, DHA and n-3-PUFAs.…”

Section: Preventive Effects On Cvd Of N-3 Pufa and Dha In Studies In mentioning

confidence: 99%

Docosahexaenoic acid regulates vascular endothelial cell function and prevents cardiovascular disease

Yamagata

2017

Lipids Health Dis

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Docosahexaenoic acid (DHA) is present in high concentrations in salmon, herring, and trout. Epidemiologic studies have shown that high dietary consumption of these and other oily fish is associated with reduced rates of myocardial infarction, atherosclerosis, and other ischemic pathologies. Atherosclerosis is induced by inflammation and can lead to acute cardiovascular events and extensive plaque. DHA inhibits the development of inflammation in endothelial cells, alters the function and regulation of vascular biomarkers, and reduces cardiovascular risk. It also affects vascular relaxation and constriction by controlling nitric oxide and endothelin 1 production in endothelial cells. DHA also contributes to the prevention of arteriosclerosis by regulating the expression of oxidized low density lipoprotein receptor 1, plasminogen activator inhibitor 1, thromboxane A2 receptor, and adhesion molecules such as vascular cell adhesion molecule-1, monocyte chemoattractant protein-1, and intercellular adhesion molecule 1 in endothelial cells. Recent research showed that DHA reduces the increase in adhesion factor expression induced by lipopolysaccharide by suppressing toll-like receptor 4. A new mechanism of action of DHA has been described that is mediated through endothelial free fatty acid receptor 4, associated with heme oxygenase 1 induction by Nrf2. However, the efficacy and mechanisms of action of DHA in cardiovascular disease prevention are not yet completely understood. The aim of this paper was to review the effects of DHA on vascular endothelial cells and recent findings on their potential for the prevention of circulatory diseases.

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“…identified PVS as an important biomarker of SVD. The presence of PVS has now been incorporated as a biomarker of SVD in many studies 28 29 30 31 32 33 34 35 36 38 . Dilated PVS can be seen as congenital lesions but their small number, typical distribution and unusual morphology make it impossible to mistake these for dilatations associated with small vessel disease.…”

Section: Discussionmentioning

confidence: 99%

Primary Open Angle Glaucoma is Associated with MR Biomarkers of Cerebral Small Vessel Disease

Mercieca

Cain

Hansen

et al. 2016

Sci Rep

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This prospective study tests the hypotheses that: 1) glaucoma is associated with evidence of cerebral small vessel disease; 2) that imaging biomarkers of cerebral small vessel disease in POAG and NTG will show different characteristics. 12 normal controls, 7 patients with primary open angle glaucoma (POAG) and 9 patients with normal tension glaucoma (NTG) were recruited. Ophthalmological clinical assessment and MR imaging of the brain were performed. MR imaging was used to quantify white matter lesion load, frequency of dilated perivascular spaces (PVS) and abnormalities in cerebral hydrodynamics. Patients with POAG had significantly greater white matter lesion load (p < 0.05), more PVS in the centrum semiovale (p < 0.05) and had higher overall PVS scores than controls (p < 0.05). In the POAG group, optic cup-to-disc ratio (CDR) was positively correlated with deep white matter hyperintensities (R2 = 0.928, p < 0.01). Mean deviation on the Humphrey visual field assessment was negatively correlated with deep white matter lesion load (R2 = −0.840, p < 0.01), total white matter lesion load (R2 = −0.928, p < 0.01) and total PVS (R2 = −0.820, p < 0.01). MR evidence of cerebral small vessel disease is strongly associated with a diagnosis of POAG and with the severity of abnormalities in CDR and visual field.

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Low levels of plasma omega 3-polyunsaturated fatty acids are associated with cerebral small vessel diseases in acute ischemic stroke patients

Cited by 35 publications

References 35 publications

Moderate-to-severe obstructive sleep apnea is associated with cerebral small vessel disease

Moderate-to-severe obstructive sleep apnea is associated with cerebral small vessel disease

Docosahexaenoic acid regulates vascular endothelial cell function and prevents cardiovascular disease

Primary Open Angle Glaucoma is Associated with MR Biomarkers of Cerebral Small Vessel Disease

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