“…Low vitamin D levels are associated with HF and atrial fibrillations (AF) in HF patients [92]. Low levels of vitamin D are significantly associated with more extensive left atrial fibrosis in patients with lone paroxysmal AF as well as with recurrence of AF after cryoablation [93] and post coronary-artery bypass graft surgery [94].…”
Vitamin D is critical in mineral homeostasis and skeletal health, and plays regulatory role in non-skeletal tissues. Vitamin D deficiency is associated with chronic inflammatory diseases, including diabetes and obesity both being strong risk factors for cardiovascular diseases (CVD). CVD, including coronary artery disease, myocardial infarction, hypertrophy, cardiomyopathy, cardiac fibrosis, heart failure, aneurysm, peripheral arterial disease, hypertension, and atherosclerosis, are major causes of morbidity and mortality worldwide. The association of these diseases with vitamin D deficiency and improvement with vitamin D supplementation suggest its therapeutic benefit. Here, we critically review the recent findings on the association of vitamin D deficiency and CVD.
“…Low vitamin D levels are associated with HF and atrial fibrillations (AF) in HF patients [92]. Low levels of vitamin D are significantly associated with more extensive left atrial fibrosis in patients with lone paroxysmal AF as well as with recurrence of AF after cryoablation [93] and post coronary-artery bypass graft surgery [94].…”
Vitamin D is critical in mineral homeostasis and skeletal health, and plays regulatory role in non-skeletal tissues. Vitamin D deficiency is associated with chronic inflammatory diseases, including diabetes and obesity both being strong risk factors for cardiovascular diseases (CVD). CVD, including coronary artery disease, myocardial infarction, hypertrophy, cardiomyopathy, cardiac fibrosis, heart failure, aneurysm, peripheral arterial disease, hypertension, and atherosclerosis, are major causes of morbidity and mortality worldwide. The association of these diseases with vitamin D deficiency and improvement with vitamin D supplementation suggest its therapeutic benefit. Here, we critically review the recent findings on the association of vitamin D deficiency and CVD.
“…Ozcan et al [32] also rigorously screened subjects and found out that vitamin D deficiency was associated with new-onset AF in hypertension. Also, in patients with chronic heart failure, low vitamin D concentrations were an independent risk factor for non-valvular AF, and the study also ruled out many chronic diseases [33] .…”
Atrial fibrillation is a common type of arrhythmia and is an important cause of
stroke and heart failure. vitamin D is an emerging risk factor of AF, and is
implicated in the pathophysiology of atrial fibrillation. It has been
established that this vitamin is extensively involved in the regulation of both
the renin angiotensin aldosterone system and the immune system. Epidemiological
studies have not yet reached a consensus on the possible association between
vitamin D deficiency and atrial fibrillation. Better research designs and
methods can further clarify the relationship between the two.
“…In patients after coronary artery bypass surgery (CABG), the relationship between POAF (postoperative atrial fibrillation) with vitamin D deficiency is even more contradictory, although the significant negative correlation between 25(OH)D levels and left atrial diameter has been observed [ 167 , 168 ]. On the other hand, low plasma concentration of vitamin D was strongly associated with AF in patients with chronic CHF [ 169 ].…”
Cardiovascular diseases are the leading cause of mortality worldwide. Therefore, a better understanding of their pathomechanisms and the subsequent implementation of optimal prophylactic and therapeutic strategies are of utmost importance. A growing body of evidence states that low-grade inflammation is a common feature for most of the cardiovascular diseases in which the contributing factors are the activation of toll-like receptors (TLRs) and vitamin D deficiency. In this article, available data concerning the association of cardiovascular diseases with TLRs and vitamin D status are reviewed, followed by a discussion of new possible approaches to cardiovascular disease management.
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