Low-level ozone has both respiratory and systemic effects in African American adolescents with asthma despite asthma controller therapy

Hernández, Michelle; Dhingra, Radhika; Burbank, Allison J.; Todorich, Krista; Loughlin, Ceila E.; Frye, Marcia; Duncan, Kelly; Robinette, Carole; Mills, Katherine; Devlin, Robert B.; Peden, David B.; Díaz-Sánchez, David

doi:10.1016/j.jaci.2018.08.003

Cited by 24 publications

(26 citation statements)

References 6 publications

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“…Interestingly, we identified that no usage of an indoor air purifier during exposure to high levels of outdoor air pollution was associated with moderate/severe asthma when mild intermittent asthma was considered as a reference. Air pollution is known to affect respiratory health, including asthma, with increases in hospitalization 30. In a previous study, the use of high-efficiency particulate air (HEPA) filters decreased the frequency of unscheduled clinic visits due to asthma exacerbation in children 31.…”

Section: Discussionmentioning

confidence: 98%

Associated Factors for Asthma Severity in Korean Children: A Korean Childhood Asthma Study

Lee

Song

Kim

et al. 2020

Allergy Asthma Immunol Res

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PurposeChildhood asthma has a considerable social impact and economic burden, especially in severe asthma. This study aimed to identify the proportion of childhood asthma severity and to evaluate associated factors for greater asthma severity.MethodsThis study was performed on 667 children aged 5–15 years with asthma from the nationwide 19 hospitals in the Korean childhood Asthma Study (KAS). Asthma was classified as mild intermittent, mild persistent, and moderate/severe persistent groups according to the National Asthma Education and Prevention Program recommendations. Multinomial logistic regression models were used to identify the associated factors for greater asthma severity.ResultsMild persistent asthma was most prevalent (39.0%), followed by mild intermittent (37.6%), moderate persistent (22.8%), and severe persistent asthma (0.6%). Onset later than 6 years of age (adjusted odds ratio [aOR], 1.69 for mild persistent asthma; aOR, 1.92 for moderate/severe persistent asthma) tended to increase asthma severity. Exposure to environmental tobacco smoke (aOR, 1.53 for mild persistent asthma; aOR, 1.85 for moderate/severe persistent asthma), and current dog ownership with sensitization to dog dander (aOR, 5.86 for mild persistent asthma; aOR, 6.90 for moderate/severe persistent asthma) showed increasing trends with greater asthma severity. Lower maternal education levels (aOR, 2.32) and no usage of an air purifier in exposure to high levels of outdoor air pollution (aOR, 1.76) were associated with moderate/severe persistent asthma.ConclusionsModification of identified environmental factors associated with greater asthma severity might help better control childhood asthma, thereby reducing the disease burden due to childhood asthma.

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Section: Discussionmentioning

confidence: 98%

Associated Factors for Asthma Severity in Korean Children: A Korean Childhood Asthma Study

Lee

Song

Kim

et al. 2020

Allergy Asthma Immunol Res

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“… 99 , 100 Also in the lower airways, short-term natural increase in ambient air ozone was associated with deteriorating lungh function tests in atopic asthmatics despite use of proper asthma controller therapy. 101 Similarly, an ozone exposure protocol revealed atopic asthmatics expressed depressed spirometry testing results compared to healthy volunteers. 102 Along with this, climate chamber studies revealed (ozone) exposure of healthy or allergic asthmatics induces a neutrophilic 103 or a mixed neutrophilic and eosinophilic 104 inflammatory profile in the lower airways, respectively.…”

Section: Comparative Analysis Of Oxidative Stress-mediated Immunopathmentioning

confidence: 98%

Immunopathological features of air pollution and its impact on inflammatory airway diseases (IAD)

Rouadi¹,

Idriss²,

Naclerio³

et al. 2020

World Allergy Organization Journal

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Air pollution causes significant morbidity and mortality in patients with inflammatory airway diseases (IAD) such as allergic rhinitis (AR), chronic rhinosinusitis (CRS), asthma, and chronic obstructive pulmonary disease (COPD). Oxidative stress in patients with IAD can induce eosinophilic inflammation in the airways, augment atopic allergic sensitization, and increase susceptibility to infection. We reviewed emerging data depicting the involvement of oxidative stress in IAD patients. We evaluated biomarkers, outcome measures and immunopathological alterations across the airway mucosal barrier following exposure, particularly when accentuated by an infectious insult.

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“…Children who live near major roadways and exposed to traffic-related air pollution have increased susceptibility to asthma. A recent study has shown that exposure to air ozone levels at sub-NAAQS thresholds is associated with pulmonary and systemic changes in African American adolescents with asthma [64]. In general, the burden of air pollution related asthma is associated with a lower socioeconomic status, and is thus a health equity issue [65].…”

Section: Air Pollutionmentioning

confidence: 99%

Epidemiology and risk factors for asthma

Kuruvilla

Vanijcharoenkarn

Shih

et al. 2019

Respiratory Medicine

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Low-level ozone has both respiratory and systemic effects in African American adolescents with asthma despite asthma controller therapy

Cited by 24 publications

References 6 publications

Associated Factors for Asthma Severity in Korean Children: A Korean Childhood Asthma Study

Associated Factors for Asthma Severity in Korean Children: A Korean Childhood Asthma Study

Immunopathological features of air pollution and its impact on inflammatory airway diseases (IAD)

Epidemiology and risk factors for asthma

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