Low level of tracheal cellular fibronectin in extremely premature infants with funisitis: Relationship with respiratory distress 1 month after birth

Arai, Hirokazu; Ito, Tomoo; Adachi, Hiroyuki; Goto, Ryoji; Takahashi, Tsutomu

doi:10.1002/ppul.22910

Cited by 2 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…decreased cellular fibronectin level). 8,14 Hirata et al also reported an association between the cystic/bubbly pattern and intrauterine inflammation, as well as an association between bubbly/cystic appearance on chest radiograph and obstructive lung disease in school-age children. 7 Whether CAM is associated with the risk factors for BPD, however, remains debatable.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Impact of chest radiography‐based definition of bronchopulmonary dysplasia

Arai

Ito

et al. 2019

Pediatrics International

Self Cite

View full text Add to dashboard Cite

Background Bubbly/cystic appearance on chest radiograph is an important factor in severe‐type bronchopulmonary dysplasia (BPD) in Japan. The aim of this study was to determine the perinatal characteristics and neonatal complications of the bubbly/cystic(+) group in extremely preterm infants with BPD, that is, oxygen dependency at day 28 after birth (BPD28). Methods This was a multicenter retrospective cohort study of population data from infants (birthweight, <1,500 g) enrolled in the Neonatal Research Network of Japan. Of the 15 480 infants born at <28 weeks’ gestational age (GA) between 2003 and 2012, 8,979 met the BPD28 criteria. The BPD28 infants were classified according to bubbly/cystic appearance on radiograph (±) at >28 postnatal days. Results The bubbly/cystic(+) group had lower GA and birthweight and required longer mechanical ventilation and oxygen dependency than the bubbly/cystic(−) group. After adjustment for confounding factors, bubbly/cystic appearance was an independent risk factor for home oxygen therapy at discharge. Conclusion Bubbly/cystic appearance on chest radiograph was a predictor of short‐term respiratory outcomes in infants with BPD28, which is diagnosed much earlier (≥28 postnatal days), and has a potentially different etiology to BPD36 (oxygen and/or positive pressure respiratory support dependency at 36 weeks’ postmenstrual age).

show abstract

Section: Discussionmentioning

confidence: 97%

“…Bubbly/cystic appearance on chest radiograph is associated with intrauterine infection/inflammation, which is associated with increased tracheal neutrophil elastase or extracellular matrix degradation (e.g. decreased cellular fibronectin level) . Hirata et al .…”

Section: Discussionmentioning

confidence: 99%

Impact of chest radiography‐based definition of bronchopulmonary dysplasia

Arai

Ito

et al. 2019

Pediatrics International

Self Cite

View full text Add to dashboard Cite

show abstract

The Role of the Interleukin-1 Family in Complications of Prematurity

Green

Garrick

Peterson

et al. 2023

IJMS

View full text Add to dashboard Cite

Preterm birth is a major contributor to neonatal morbidity and mortality. Complications of prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary hypertension associated with BPD (BPD-PH, heart), white matter injury (WMI, brain), retinopathy of prematurity (ROP, eyes), necrotizing enterocolitis (NEC, gut) and sepsis are among the major causes of long-term morbidity in infants born prematurely. Though the origins are multifactorial, inflammation and in particular the imbalance of pro- and anti-inflammatory mediators is now recognized as a key driver of the pathophysiology underlying these illnesses. Here, we review the involvement of the interleukin (IL)-1 family in perinatal inflammation and its clinical implications, with a focus on the potential of these cytokines as therapeutic targets for the development of safe and effective treatments for early life inflammatory diseases.

show abstract

Low level of tracheal cellular fibronectin in extremely premature infants with funisitis: Relationship with respiratory distress 1 month after birth

Abstract: Decreased EDA + FN in TAF might be one of the risk factors leading to respiratory distress in extremely premature infants with funisitis.

Cited by 2 publications

References 24 publications

Impact of chest radiography‐based definition of bronchopulmonary dysplasia

Impact of chest radiography‐based definition of bronchopulmonary dysplasia

The Role of the Interleukin-1 Family in Complications of Prematurity

Contact Info

Product

Resources

About