Low Level of Antithrombin Iii as a Warning Sign for Developing Thrombotic Complications in Surgical Patients

Zolotukhin, K. N.; Krüger, Philipp; Самородов, Александр В.

doi:10.24060/2076-3093-2018-8-1-52-56

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…Независимо от вида оперативного лечения помимо коррекции нутритивного статуса всем пациентам проводилась профилактика тромбоэмболических и инфекционных осложнений по показаниям [8,9], мониторинг центральной гемодинамики [11] и биохимических маркеров повреждения печени и нутритивной недостаточности [12].…”

Section: материалы и методыunclassified

Correction of nutritional status in patients with focal liver diseases

Грицаенко

Нартайлаков

Fedorov

et al. 2023

jour

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Purpose of the research. To study the effect of nutritional support on the results of treatment of patients after liver resection for its focal neoplasms.Materials and methods. Nutritional status at the pre- and inpatient stages was studied based on the examination of 74 patients with focal liver neoplasms. Through a comprehensive clinical and laboratory examination, were identified groups of patients with mild, moderate and severe malnutrition were identified. Comparison groups were formed from them to develop corrective measures aimed at minimizing the phenomena of nutritional deficiency and reducing the frequency ofpurulent- septic complications from wounds.Results. As a result of the study, it was revealed that after undergoing large and extended liver resections, a mild degree of malnutrition was noted in 18 (47.4%) patients in the main group and in 16 (44.4%) patients in the control group (p = 0.796). The average degree of malnutrition was recorded in 7 (18.4%) patients in the main group and in 5 (13.9%) patients in the control group (p = 0.641). Severe malnutrition was observed in 3 (7.9% and 8.3%, respectively) patients in the analyzed groups (p = 0.796). It has been proven that the use of ATP allows accelerating the normalization of nutritional status in patients who underwent liver resection, compared with patients who did not receive nutritional support, up to 5.5 ± 2.2 days compared to 12.8 ± 3.9 in the second group (p <0.001). Nutritional support with the use of enteral nutrition on day 2 after surgery makes it possible to improve PS markers, which, as a result, helps to reduce the number of septic complications by 9% in the main group.Conclusion. The use of ATP allows to normalize the nutritional status in patients who underwent liver resection, compared with patients who did not receive nutritional support, up to 5.5 ± 2.2 days compared to 12.8 ± 3.9 in the second group (p < 0.001). After liver resection in the early postoperative period, nutritional support with enteral nutrition on day 2 after surgery allows improving PS markers, which, as a result, helps to reduce the number of purulent- septic complications by 9% compared to patients who did not receive nutritional support.

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Section: материалы и методыunclassified

Correction of nutritional status in patients with focal liver diseases

Грицаенко

Нартайлаков

Fedorov

et al. 2023

jour

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“…Examples include products based on fibrin or thrombin for local hemostasis in abdominal surgery or traumatology [1], proton-pump inhibitors to prevent recurrence of bleeding from the gastrointestinal tract [2], antifibrinolytic funds, and desmopressin for the system hemostasis [3]. However, drugs to stop bleeding, traditionally used in medical practice, are not always effective to lead to the effective reduction of blood loss which is dangerous due to the development of hemorrhagic shock, dilutional coagulopathy, or thrombosis and thromboembolic complications [4]. Overview of clinical recommendations shows that among synthetic systemic hemostatic drugs, the highly proved efficacy was confirmed only for tranexamic acid, aminocaproic acid, and etamsylate [5,6].…”

Section: Introductionmentioning

confidence: 99%

The Hemostatic Activity of Bis (2-Aminoethan-1-Sulfonate) Calcium

Гуревич

Ураков

Баширова

et al. 2018

Asian J Pharm Clin Res

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Objective: It is known that local or systemic injection of hemostatic drugs is used to reduce blood loss and number of blood transfusions in patients with hypocoagulation and hemorrhagic diathesis. However, the analysis of literature data shows that the drugs applied for the control of bleeding, traditionally used in medical practice, are not effective enough. This study deals with the systemic hemostatic activity of bis (2-aminoethan-1- sulfonate) calcium in the experiment.Methods: Experimental work in vitro is performed on the blood of healthy male donors, under conditions in vivo it is done on intraperitoneal injection in male rats. Thromboelastography was carried out with apparatus Thromboelastography (TEG) 5000 (Haemoscope Corporation, United States). The influence of first synthesized derivative and ethamsylate on functional activity of platelets was studied using a platelet aggregation analyzer “Biola 230LA” (Russia). Experimental evaluation of the system specific hemostatic activity in vivo was carried out using the model of parenchymatous bleeding in mature male rats. The interference came amid registration of bleeding stop time and extent of blood loss.Results: Bis (2-aminoethan-1-sulfonate) calcium shows procoagulation and proaggregant activity both in vitro and in vivo. Proaggregatory effect of bis (2-aminoethan-1-sulfonate) calcium is successfully implemented in the systemic hemostatic activity in terms of parenchymal bleeding, surpassing the control group and the group of etamsylate.Conclusion: The results of these studies reveal potentially high systemic hemostatic activity of bis (2-aminoethan-1-sulfonate) calcium, urging the need for further study on this compound and its analogs to create on their basis highly efficient, selective correctors of the hemostatic system.

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