Low-level laser therapy on bone repair: is there any effect outside the irradiated field?

Batista, Jonas Dantas; Sargenti-Neto, Sérgio; Dechichi, Paula; Rocha, Flaviana Soares; Pagnoncelli, Rogério Miranda

doi:10.1007/s10103-015-1752-3

Cited by 32 publications

(36 citation statements)

References 21 publications

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“…A recent experimental study showed that LLLT had a positive local biostimulative effect in the early stages of bone healing [20]. In concordance, our results showed better bone healing after LLLT compared to the control group, with statistically significant difference (p < 0.000).…”

Section: Discussionsupporting

confidence: 90%

Usage of Low Level Laser Biostimulation and Platelet Rich Fibrin in Bone Healing: Experimental Study

Elhayes¹,

Zaky²,

Ibrahim³

et al. 2016

Dent. Med. Probl.

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Low level laser therapy (LLLT) is defined as supplying direct biostimulative light energy to the cells. The wound healing process could be enhanced using low-level semiconductor diode lasers [1]. It has been reported that absorbed laser energy stimulates the molecules and atoms of the body's cells [2].While several studies have demonstrated that LLLT has stimulating effects on stem cells of the AbstractBackground. Experimental studies have shown that low level laser therapy (LLLT) has a positive local biostimulative effect in the early stage of bone healing. Platelet rich fibrin (PRF) also has been shown to be effective in the treatment of intrabony periodontal defects. Objectives. The objective of our experimental study was to demonstrate the combined effects of LLLT and PRF on bone healing. Material and Methods. Our experimental study was done over 80 bony cavities in 20 adult male rabbits, aged 12 months. An incision was made for exposure of the femur bone of all rabbits. Then, by using a large, round surgical bur, a perforated hole was made in the femur. The cavities induced in these rabbits were divided into 4 groups: The control group which was neither subjected to any laser irradiation nor filled with any bone substitute (group I); The bony defects were filled with PRF (group II); The cavities were subjected to low level laser (LLL) for biostimulation (group III); The cavities were subjected to LLL for biostimulation then were filled with PRF (group IV). Histological assessments of the four groups were done using a hematoxylin and eosin stain. Statistical analysis was done using ANOVA and Bonferroni tests for comparisons between the four groups.Results. The area percentage of the newly formed bone in group IV was significantly higher than the other three groups. The area percentage of the newly formed bone in group III is significantly higher than group II. Conclusions. LLLT could induce bone formation in the bone defect at a faster rate than PRF. However, a combination of both LLLT and PRF as treatment modalities could induce bone formation in the bone defect more than that of LLLT or PRF alone (Dent. Med. Probl. 2016, 53, 3, 338-344).

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Section: Discussionsupporting

confidence: 90%

Usage of Low Level Laser Biostimulation and Platelet Rich Fibrin in Bone Healing: Experimental Study

Elhayes¹,

Zaky²,

Ibrahim³

et al. 2016

Dent. Med. Probl.

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“…It is possible to find in literature a wide range of fluencies and energy of laser irradiation used by different authors on bone healing and fractures [9,23,24,40]. In a recent study, Batista et al, [46] used 830 nm laser irradiation, at 6 J, and presented a positive local biostimulative effect in the early stage of bone healing. Moreover, in an in vivo study comparing the effects of the 830 nm laser, at the energy of 1.7 and at 3.4 J, showed that the higher energy was more efficient to produce newly formed bone [8].…”

Section: Discussionmentioning

confidence: 99%

Effects of low-level laser therapy on the expression of osteogenic genes during the initial stages of bone healing in rats: a microarray analysis

et al. 2015

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This study evaluated the morphological changes produced by LLLT on the initial stages of bone healing and also studied the pathways that stimulate the expression of genes related to bone cell proliferation and differentiation. One hundred Wistar rats were divided into control and treated groups. Noncritical size bone defects were surgically created at the upper third of the tibia. Laser irradiation (Ga-Al-As laser 830 nm, 30 mW, 94 s, 2.8 J) was performed for 1, 2, 3, 5, and 7 sessions. Histopathology revealed that treated animals produced increased amount of newly formed bone at the site of the injury. Moreover, microarray analysis evidenced that LLLT produced a significant increase in the expression TGF-β, BMP, FGF, and RUNX-2 that could stimulate osteoblast proliferation and differentiation, which may be related to improving the deposition of newly formed bone at the site of the injury. Thus, it is possible to conclude that LLLT improves bone healing by producing a significant increase in the expression of osteogenic genes.

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“…9,10 Phototherapy has been widely used in research of different tissues, such as tendons, peripheral nerve, skin tissue, bones, and muscle. [11][12][13][14][15][16] In this context, low-level laser therapy (LLLT), and light emitting diode therapy (LEDT) are efficient on bioenergetics muscle activation, and these effects may influence performance during physical activities. Therefore, researchers started to investigate LLLT and LEDT as a way to improve muscle performance as LLLT and LEDT induce photochemical effects on cells by light absorption at photoreceptors;phenomenon described as photobiomodulation.…”

Section: Introductionmentioning

confidence: 99%

Effect of Low-Level Laser Therapy and Strength Training Protocol on Hand Grip by Dynamometry

et al. 2017

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Introduction: The purpose of this study was to investigate the effect of low-level laser therapy (LLLT) -660 nm and 904 nm -before grip strength protocol in healthy subjects. Methods:The study included 45 healthy volunteers with an average age of 22.7 (±1.4) years, subdivided into the following groups, control group: grip strength training associated with placebo LLLT; 660 nm group: LLLT (660 nm, 20 J/cm 2 , power of 30 mW, and beam area of 0.06 cm 2 , continuous, energy 1.2 J, and exposure time 40 seconds per point) before grip strength training and 904 nm group: LLLT (904 nm, 10 J/cm 2 , peak power of 70 W and 0.13 cm 2 beam area, with pulsed beam 9.500 Hz and 30 seconds of exposure time per point and emitted energy 1.2 J) before grip strength training. The LLLT was timed to contact 10 points located in the region of the superficial and deep flexor muscles of the fingers, with a total energy of 12.0 J per session. For the strength training protocol, the volunteer exercised their fingers with the dominant hand on a small table, elbow flexed at 90°, forearm in neutral, using a light extension handle. The Oxford protocol was performed during four weeks. The grip strength was assessed using a dynamometer (Jamar™). The data were evaluated by the analysis of variance (ANOVA) statistical method. Results: In the comparison of intragroup evaluation, only the 904 nm group showed a difference compared to the baseline assessment after 4 weeks (P < 0.05), in the final intergroup evaluation, a difference was observed in the comparison between the control and 904 nm groups. Conclusion: In conclusion, LLLT (904 nm) applied before resistance training was effective in gaining grip strength when compared to LLLT (660 nm) and isolated strength training after 4 weeks.

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Low-level laser therapy on bone repair: is there any effect outside the irradiated field?

Cited by 32 publications

References 21 publications

Usage of Low Level Laser Biostimulation and Platelet Rich Fibrin in Bone Healing: Experimental Study

Usage of Low Level Laser Biostimulation and Platelet Rich Fibrin in Bone Healing: Experimental Study

Effects of low-level laser therapy on the expression of osteogenic genes during the initial stages of bone healing in rats: a microarray analysis

Effect of Low-Level Laser Therapy and Strength Training Protocol on Hand Grip by Dynamometry

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