Low-Level Laser Therapy (GaAs<i>λ</i>= 904 nm) Reduces Inflammatory Cell Migration in Mice with Lipopolysaccharide-Induced Peritonitis

Corrêa, Fernanda Ishida; Martins, Rodrigo Alvaro Brandão Lopes; Corrêa, João Carlos Ferrari; Iversen, Vegard Vereide; Joenson, Jon; Bjordal, Jan Magnus

doi:10.1089/pho.2007.2079

Cited by 66 publications

(43 citation statements)

References 28 publications

(29 reference statements)

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“…19 In the last years several animal and human trials have shown that low-level laser therapy (LLLT) has modulatory effects on inflammatory markers (prostaglandin E 2 -PGE 2 , TNF-a, IL-1b, plasminogen activator, COX-1 and COX-2), reduces the inflammatory process itself (edema, hemorrhagic formation, necrosis, and neutrophil cell influx), and modulates leucocyte activity (macrophages, lymphocytes, and neutrophils). [20][21][22][23][24][25][26][27] LLLT has presented mixed results in clinical studies of acute tendinitis and other tendinopathies in last three decades, but the mechanisms behind effects are not fully understood. In a recent study of our research group, we observed that LLLT with 3 J energy significantly decreased acute inflammatory process through selective inhibition of the COX-2 isoform in collagenase-induced tendinitis.…”

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confidence: 99%

Low‐level laser therapy in collagenase‐induced Achilles tendinitis in rats: Analyses of biochemical and biomechanical aspects

Marcos

Leal-Junior

Arnold

et al. 2012

Journal Orthopaedic Research

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NSAIDs are widely prescribed and used over the years to treat tendon injuries despite its well-known long-term side effects. In the last years several animal and human trials have shown that low-level laser therapy (LLLT) presents modulatory effects on inflammatory markers, however the mechanisms involved are not fully understood. The aim of this study was to evaluate the shortterm effects of LLLT or sodium diclofenac treatments on biochemical markers and biomechanical properties of inflamed Achilles tendons. Wistar rats Achilles tendons (n ¼ 6/group) were injected with saline (control) or collagenase at peritendinous area of Achilles tendons. After 1 h animals were treated with two different doses of LLLT (810 nm, 1 and 3 J) at the sites of the injections, or with intramuscular sodium diclofenac. Regarding biochemical analyses, LLLT significantly decreased (p < 0.05) COX-2, TNF-a, MMP-3, MMP-9, and MMP-13 gene expression, as well as prostaglandin E 2 (PGE 2 ) production when compared to collagenase group. Interestingly, diclofenac treatment only decreased PGE 2 levels. Biomechanical properties were preserved in the laser-treated groups when compared to collagenase and diclofenac groups. We conclude that LLLT was able to reduce tendon inflammation and to preserve tendon resistance and elasticity. ß

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confidence: 99%

Low‐level laser therapy in collagenase‐induced Achilles tendinitis in rats: Analyses of biochemical and biomechanical aspects

Marcos

Leal-Junior

Arnold

et al. 2012

Journal Orthopaedic Research

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“…When mice with lipopolysaccharide-induced peritonitis were irradiated with a 904-nm gallium arsenide laser, inflammatory cell migration was inhibited [8]. In a rat model of carrageenan-induced pleuritis, a 660-nm indium-gallium-aluminum-phosphate laser suppressed the production of inflammatory cytokines and the migration of inflammatory cells [9].…”

Section: Antiinflammatory Actionmentioning

confidence: 99%

Biological Function of Low Reactive Level Laser Therapy (LLLT)

Kubota¹,

Ishihara²

2017

Photomedicine - Advances in Clinical Practice

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Low reactive level laser therapy (LLLT) and photobiomodulation are mainly focused on the activation of intracellular or extracellular photoabsorbable molecule (chromophore) and the initiation of cellular signaling using low power lasers and lights. Over the past 40 decades, a number of basic and clinical researches were reported that the laser therapy had the potential to improve wound healing and reduce pain and inflammation. In recent years, the term "LLLT" has become widely recognized. In this review, the mechanisms of action of LLLT at a cellular level are described. Finally, our recent research results that LLLT enhanced the cells differentiation are also described.

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“…A irradiação com laser na região vermelha do espectro eletromagnético diminui a quantidade de células inflamatórias, também exerce efeito estimulador sobre TGF-α (Tumor Growth Factor alpha), e PDGF (Platelet-derived growth factor), sendo que o estímulo a esses fatores de crescimento relaciona-se diretamente ao processo de reparo (Albertini et al, 2007;Correa et al, 2007;Piva et al, 2011). Klebanov et al (2005) estudaram o efeito da luz coerente (laser) e não coerente (LED) sobre a atividade funcional do exsudato leucocitário, em feridas cutâneas de ratos.…”

Section: Figure 7 Inflammatory Cells Count Of the Control Groups 3 (unclassified

Efeito da terapia LED (» = 945 ± 20 nm) de baixa intensidade sobre tecido epitelial de ratos diabéticos em processo de reparo

Ferreira¹,

Nicolau²,

Oliveira³

et al. 2013

RBEB

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Resumo Introdução: O diabetes mellitus é uma condição sistêmica que pode causar retardo da resposta tecidual frente a uma lesão. Diversos estudos têm apontado o laser como importante ferramenta terapêutica para o auxílio do processo de reparo tecidual. Contudo, poucos estudos foram realizados com o emprego de LED (Light Emitting Diode). Assim, o objetivo deste trabalho foi analisar o efeito da terapia com LED (λ = 945 ± 20nm) de baixa intensidade sobre tecido epitelial de ratos diabéticos em processo de reparo. Métodos: Para tal, foi realizada a indução de diabetes experimental em 20 ratos machos (Wistar), com administração de 40mg/kg, por via endovenosa, de mono-hidrato de aloxana diluído em solução tampão. Após 14 dias, os animais foram submetidos à incisão tecidual na região dorsal, seguida de sutura e divididos em grupo-controle (GI e GIII, 3 e 7 dias pós-lesão, respectivamente), e grupo-tratado com LED (GII e GIV, 3 e 7 dias pós-lesão, respectivamente). Os animais do grupo tratado (n = 10) foram irradiados de forma transcutânea, em duas sessões (30 minutos e 48 horas pós-lesão). Resultados: O número de fi broblastos foi signifi cativamente maior no GIV em relação ao GIII. Conclusão: Considerando o aumento do número de fi broblastos (análise quantitativa) e o adequado fechamento da lesão (análise qualitativa), pode-se concluir que houve um efeito positivo da terapia LED na região do infravermelho próximo sobre o processo de reparo, após 7 dias de lesão tecidual em animais diabéticos (GIV). (GI and GIII, respectively) and groups treated with LED (GII and GIV, respectively Palavras-chave LED, Reparo tecidual, Diabetes mellitus. Low level LED therapy (λ = 945 ± 20 nm) effect on epithelial tissue of diabetic rats during repairing process

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Low-Level Laser Therapy (GaAsλ= 904 nm) Reduces Inflammatory Cell Migration in Mice with Lipopolysaccharide-Induced Peritonitis

Abstract: Low-level laser therapy (904 nm) can reduce inflammatory cell migration in mice with LPS-induced peritonitis in a dose-dependent manner.

Cited by 66 publications

References 28 publications

Low‐level laser therapy in collagenase‐induced Achilles tendinitis in rats: Analyses of biochemical and biomechanical aspects

Low‐level laser therapy in collagenase‐induced Achilles tendinitis in rats: Analyses of biochemical and biomechanical aspects

Biological Function of Low Reactive Level Laser Therapy (LLLT)

Efeito da terapia LED (» = 945 ± 20 nm) de baixa intensidade sobre tecido epitelial de ratos diabéticos em processo de reparo

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