Low-level exposure to lead, blood pressure, and hypertension in a population-based cohort

Gambelunghe, Angela; Sällsten, Gerd; Borné, Yan; Forsgard, Niklas; Hedblad, Bo; Nilsson, Peter M.; Fagerberg, Björn; Engström, Gunnar; Barregård, Lars

doi:10.1016/j.envres.2016.05.015

Cited by 114 publications

(52 citation statements)

References 24 publications

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“…• Lead: Long-term exposure to lead in adults has been associated with higher BP in population studies 295,296 and in studies of industrial workers with high lead exposure, 297 although findings have not been consistent. 298 At least 1 cross-sectional study of 122 children demonstrated that children with higher blood lead concentrations had higher BP; lower socioeconomic status was also seen in this group, which may have confounded the BP results.…”

Section: Secondary Causes: Environmental Exposuresmentioning

confidence: 99%

Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents

et al. 2017

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These pediatric hypertension guidelines are an update to the 2004 "Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents." Significant changes in these guidelines include (1) the replacement of the term "prehypertension" with the term "elevated blood pressure," (2) new normative pediatric blood pressure (BP) tables based on normal-weight children, (3) a simplified screening table for identifying BPs needing further evaluation, (4) a simplified BP classification in adolescents ≥13 years of age that aligns with the forthcoming American Heart Association and American College of Cardiology adult BP guidelines, (5) a more limited recommendation to perform screening BP measurements only at preventive care visits, (6) streamlined recommendations on the initial evaluation and management of abnormal BPs, (7) an expanded role for ambulatory BP monitoring in the diagnosis and management of pediatric hypertension, and (8) revised recommendations on when to perform echocardiography in the evaluation of newly diagnosed hypertensive pediatric patients (generally only before medication initiation), along with a revised definition of left ventricular hypertrophy. These guidelines include 30 Key Action Statements and 27 additional recommendations derived from a comprehensive review of almost 15 000 published articles between January 2004 and July 2016. Each Key Action Statement includes level of evidence, benefit-harm relationship, and strength of recommendation. This clinical practice guideline, endorsed by the American Heart Association, is intended to foster a patient- and family-centered approach to care, reduce unnecessary and costly medical interventions, improve patient diagnoses and outcomes, support implementation, and provide direction for future research.

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Section: Secondary Causes: Environmental Exposuresmentioning

confidence: 99%

Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents

et al. 2017

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“…The other important ion is lead. This ion elevated blood pressure causes sleep disturbances and anemia . Arsenic ions exists in human and animal tissues have significant toxic effects.…”

Section: Introductionmentioning

confidence: 99%

A novel optical probe based on d‐penicillamine‐functionalized graphene quantum dots: Preparation and application as signal amplification element to minoring of ions in human biofluid

Pashazadeh-Panahi

Hasanzadeh

Eivazzadeh‐Keihan

2020

J of Molecular Recognition

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In this study, d‐penicillamine‐functionalized graphene quantum dots (DPA‐GQD) has been synthesized, which significantly increases the fluorescence intensity of GQD. We used this simple fluorescent probe for metal ions detection in human plasma samples. Designed DPA‐GQD respond to Hg2+, Cu2+, Au2+, Ag+, Co2+, Zn2+, and Pb2+ with high sensitivity. The fluorescence intensity of this probe decreased significantly in the presence of metal ions such as, Hg2+, Cu2+, Au2+, Ag+, Co2+, Zn2+, and Pb2+. In this work, a promising probe for ions monitoring was introduced. Moreover, DPA‐GQD probe has been tested in plasma samples. The functionalized DPA‐GQDs exhibits great promise as an alternative to previous fluorescent probes for bio‐labeling, sensing, and other biomedical applications in aqueous solution.

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“…Lead induced hypertension has been shown to occur even in the absence of symptomatic lead intoxication and even before the onset of clinically apparent renal impairment [2] [3] [4]. Several epidemiologic studies [5] [6] [7] [8] [9] have shown that relatively low level of lead exposure is associated with a significant increase in blood pressure. This epidemiological association of lead exposure and elevated blood pressure has been shown to contribute largely to the disease burden attributable to lead, as a result of its associated cardiovascular risk [10] [11].…”

Section: Introductionmentioning

confidence: 99%

The Blood Lead, Blood Pressure Connection: An Evaluation of Apparently Healthy Lead Exposed Workers in Nigeria

Alasia¹,

Iyagba²

2019

ODEM

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Objective: There is a paucity of evidence on the lead exposure and blood pressure association in Nigeria where lead exposure is still prevalent and poorly regulated. The objective of this study was to evaluate the association between lead exposure using blood lead level and blood pressure in Port Harcourt Nigeria. Methodology: A prospective cross sectional comparative study of adult subjects with occupational lead exposure and controls, performed in Port Harcourt, South-south Nigeria. Blood lead measured by atomic absorption spectrophotometry was used as the biomarker of lead exposure while systolic and diastolic blood pressures and other relevant variables were measured and analysed. Results: The mean systolic blood pressure was significantly higher in lead exposed subjects 118.49 (14.67) mmHg compared to controls 113.62 (11.31) mmHg (p = 0.008). No difference was observed in the mean diastolic blood pressure. A higher proportion of subjects had systolic and diastolic pressure > 140 mmHg and >90 mmHg compared to controls 9.47% vs. 1.25% and 10.51% vs. 2.54%, with (p = 0.016), OR = 8.27 < 1.14 < OR < 169.09>, RR = 1.38 < 1.21 < RR < 1.58> and (p = 0.028), OR = 4.59 < 1.00 < OR < 29.15>, RR = 1.33 < 1.13 < RR < 1.55> respectively. There was no significant statistical correlation between blood lead and blood pressure. Conclusion: The results of this study indicate a significant systolic blood pressure elevation and prevalence of hypertension among lead exposed workers in Port Harcourt Nigeria. Lager longitudinal research is needed to evaluate lead exposure and elevated blood pressure association in Nigeria. The findings call for better regulation of occupational lead exposure in Nigeria.

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Low-level exposure to lead, blood pressure, and hypertension in a population-based cohort

Abstract: Low-level lead exposure increases blood pressure and may increase the risk of hypertension.

Cited by 114 publications

References 24 publications

Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents

Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents

A novel optical probe based on d‐penicillamine‐functionalized graphene quantum dots: Preparation and application as signal amplification element to minoring of ions in human biofluid

The Blood Lead, Blood Pressure Connection: An Evaluation of Apparently Healthy Lead Exposed Workers in Nigeria

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