Low Km aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes.

Morimoto, Kanehisa; Takeshita, Tatsuya

doi:10.1289/ehp.96104s3563

Cited by 44 publications

(23 citation statements)

References 21 publications

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“…Morimoto and Takeshita (41) observed that ALDH2-deficient habitual alcohol drinkers had higher mean frequency of SCEs in lymphocytes than ALDH2-proficient individuals who consumed alcohol daily. This effect probably reflected the higher acetaldehyde levels found in the peripheral blood of the ALDH2-deficient subjects who also showed an elevated level of acetaldehyde adducts in hemoglobin (52 Studies of cytogenetic biomarkers among exposed humans show that the determination of polymorphisms is becoming an increasingly important aspect that may make the assays more sensitive and more specific in identifying the effect and the sensitive subgroups. At present, it seems that at least GSTM1 and GSTTI genotypes of the donors should be studied on a routine basis when in vivo cytogenetic effects are concerned.…”

Section: Genetic Polymorphisms and Cytogenetic Assays In Vrtromentioning

confidence: 99%

Cytogenetic markers of susceptibility: influence of polymorphic carcinogen-metabolizing enzymes.

Norppa

1997

Environ Health Perspect

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Section: Genetic Polymorphisms and Cytogenetic Assays In Vrtromentioning

confidence: 99%

Cytogenetic markers of susceptibility: influence of polymorphic carcinogen-metabolizing enzymes.

Norppa

1997

Environ Health Perspect

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“…Studies on the genotype and phenotype of ALDH2 showed that the genotype of ALDH2 was related to the occurrence and development of excess alcohol consumption and alcohol-related diseases (Morimoto and Takeshita, 1996;Chen et al, 1997Chen et al, , 1999, and null ALDH2 activity was found in about 50% of the Mongolian population (Minami et al, 2002). The Mongolian population lives on the Mongolian plateau in North China with cold climate.…”

Section: Introductionmentioning

confidence: 99%

Acetaldehyde dehydrogenase 2 SNP rs671 and susceptibility to essential hypertension in Mongolians: a case control study

T¹,

Liang²,

Yang³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. Mongolians are known as heavy drinkers, and they have a high incidence of essential hypertension, which may be an associated pathology. We examined a possible association of essential hypertension and polymorphism of the aldehyde dehydrogenase 2 (ALDH2) gene in Mongolians from Inner Mongolia. Single nucleotide polymorphism rs671 of ALDH2 was detected by TaqMan PCR in 91 essential hypertensive patients (44 males and 47 females) and 70 healthy Mongolians (37 males and 33 females). Frequencies of the ALDH2*1/1 genotype and the ALDH2*1 allele in patients (91.2 and 95.6%, respectively) were significantly higher than in controls (78.6 and 89.3%; P < 0.05), while frequencies of ALDH2*1/2 genotype and ALDH2*2 allele in patients (8.79 and 4.4%) were much lower than in controls (21.4 and 10.7%; P < 0.05). Frequencies of ALDH2*1/1 genotype and ALDH2*1 allele in female patients (95.8 and 94.9%) were higher than in female controls (70.0 and 84.9%; P < 0.05); frequencies of the ALDH2*1/2 genotype and the ALDH2*2 allele in female patients (4.25 and 2.13%) were lower than in female controls (30.3 and 15.2%, P < 0.05). There was no significant difference in male subjects. ALDH2*2/2 was not found in any of the subjects. We conclude that ALDH2 polymorphism is associated with essential hypertension in Mongolians, especially in female Mongolians. ALDH2*2 was found to be a negative risk factor for essential hypertension in Mongolians from Inner Mongolia.

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“…Alcohol consumption is lower in individuals with ALDH2 deficiency than in those with ALDH2 sufficiency (17)(18)(19). Thus, the findings on the health effects of alcohol consumption obtained from Western populations might be mainly based on the comparison between ALDH2-sufficient drinkers and nondrinkers, whereas those from Asian populations might be based on the comparison between ALDH2-sufficient drinkers and ALDH2-sufficient or deficient nondrinkers.…”

Section: Introductionmentioning

confidence: 99%

Blood Pressure, Levels of Serum Lipids, Liver Enzymes and Blood Glucose by Aldehyde Dehydrogenase 2 and Drinking Habit in Japanese Men

Nakamura

Ito

Suzuki

et al. 2006

Environ. Health Prev. Med.

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Objectives: The association of blood pressure and levels of serum lipids, liver enzymes, blood glucose and aldehyde dehydrogenase 2 (ALDH2) with drinking habit was examined in Japanese men.Methods: The subjects were 264 men aged 39 to 80 years who were classified into the ALDH2 deficiency or sufficiency group using the ethanol patch test and the Tokyo University ALDH2 Phenotype Screening Test. A self-administered questionnaire including drinking habit was used. Blood pressure and the levels of biochemical markers in groups with ALDH2 sufficiency, ALDH2 deficiency and drinking habit were compared using multiple regression models for adjusting age, smoking habit, physical exercising habit and body mass index.Results: The levels of serum high-density lipoprotein cholesterol, triglycerides, aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase (γ-GTP) were significantly higher in current drinkers of 20 g of ethanol or more per day than in nondrinkers of the ALDH2 sufficiency group. The levels of serum AST and γ-GTP in current drinkers of 20 g of ethanol or more per day, and fasting blood sugar in current drinkers of less than 20 g of ethanol per day were significantly higher than those in nondrinkers of the ALDH2 deficiency group.Conclusions: These results suggest that alcohol consumption increases the levels of serum lipids and liver enzymes in ALDH2-sufficient individuals and liver enzymes and blood glucose levels in ALDH2-deficient individuals.

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Low Km aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes.

Cited by 44 publications

References 21 publications

Cytogenetic markers of susceptibility: influence of polymorphic carcinogen-metabolizing enzymes.

Cytogenetic markers of susceptibility: influence of polymorphic carcinogen-metabolizing enzymes.

Acetaldehyde dehydrogenase 2 SNP rs671 and susceptibility to essential hypertension in Mongolians: a case control study

Blood Pressure, Levels of Serum Lipids, Liver Enzymes and Blood Glucose by Aldehyde Dehydrogenase 2 and Drinking Habit in Japanese Men

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