Acetaldehyde dehydrogenase 2 SNP rs671 and susceptibility to essential hypertension in Mongolians: a case control study

T, Hasi; Liang, Hao; Yang, Lei; Xl, Su

doi:10.4238/vol10-1gmr1056

Cited by 26 publications

(19 citation statements)

References 14 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study has shown that the rs671 polymorphism is associated with EH risk among Mongolian women but not men [23]. Our results are contrary to those studies.…”

Section: Discussioncontrasting

confidence: 99%

Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis

Lian

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

Background and objectiveSeveral studies have been conducted to examine the association between aldehyde dehydrogenase 2 family (ALDH2) rs671 polymorphism and essential hypertension (EH). However, the results remain inconsistent. This study aimed to clarify the association between ALDH2 rs671 polymorphism and EH susceptibility.MethodsOne thousand and ninety-four cases and 1236 controls who were ethnic Han Chinese were collected for this population-based case-control study. A meta-analysis was performed to calculate the pooled odds ratio and 95% confidence interval, using allele contrast, dominant, recessive, and co-dominant models using fixed or random-effect models.ResultsSignificant differences were observed between EH cases and controls at the level of both genotype (χ2 = 6.656, P<0.05) and alleles (χ2 = 6.314, P<0.05). An additional meta-analysis using 4204 cases and 5435 controls established that rs671 was significantly associated with EH (P<0.00001).ConclusionThe results of our case-control study and meta-analysis showed that there is a significant association between ALDH2 rs671 polymorphism and EH susceptibility. In addition, the results of the breakdown analysis by gender suggest a male-specific association between the ALDH2 rs671 polymorphism and EH.

show abstract

“…A study has shown that the rs671 polymorphism is associated with EH risk among Mongolian women but not men [23]. Our results are contrary to those studies.…”

Section: Discussioncontrasting

confidence: 99%

Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis

Lian

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…A 25-µl reaction mixture including 5 µl DNA, 12.5 µl TaqMan PCR master mix, 1.25 µl primers and probes, 6.25 µl deionized water was placed in a real-time PCR instrument (Applied Biosystems, Foster City, CA, USA). The reaction conditions were as the following: initial denaturation at 95°C for 10 min, followed by 40 cycles of denaturation at 92°C for 15 sec and annealing and extension at 60°C for 90 sec [30]. …”

Section: Methodsmentioning

confidence: 99%

Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function

Zhang

et al. 2014

Free Radical Biology and Medicine

117

View full text Add to dashboard Cite

Cardiac aging is associated with compromised myocardial function and morphology although the underlying mechanism remains elusive. ALDH2, an essential mitochondrial enzyme governing cardiac function, displays polymorphism in human. This study was designed to examine the role of ALDH2 in aging-induced myocardial anomalies. Myocardial mechanical and intracellular Ca2+ properties were examined in young (4–5 mo) and old (26–28 mo) wild-type (WT) and ALDH2 transgenic mice. Cardiac histology, mitochondrial integrity, O2− generation, apoptosis and signaling cascades including AMPK activation and Sirt1 level were evaluated. Myocardial function and intracellular Ca2+ handling were compromised with advanced aging, the effects were accentuated by ALDH2. H&E and Masson trichrome staining revealed cardiac hypertrophy and interstitial fibrosis associated with greater left ventricular mass and wall thickness in aged mice. ALDH2 accentuated aging-induced cardiac hypertrophy but not fibrosis. Aging promoted O2− release, apoptosis and mitochondrial injury (mitochondrial membrane potential, levels of UCP2 and PGC-1α), the effects were also exacerbated by ALDH2. Aging dampened AMPK phosphorylation and Sirt1, the effects of which were exaggerated by ALDH2. Treatment of the ALDH2 activator Alda-1 accentuated aging-induced O2− generation and mechanical dysfunction in cardiomyocytes, the effects of which were mitigated by co-treatment with activators of AMPK and Sirt1 AICAR, resveratrol and SRT1720. Examination of human longevity revealed a positive correlation between lifespan and ALDH2 gene mutation. Taken together, our data revealed that ALDH2 enzyme may accentuate myocardial remodeling and contractile dysfunction in aging possibly through AMPK/Sirt1-mediated mitochondrial injury.

show abstract

“…After adjusting for alcohol consumption, the *504Lys allele and hypertension were no longer correlated (Takagi et al 2001;Amamoto et al 2002;Wang et al 2013). However, other studies have demonstrated that the mechanism is not related to alcohol consumption (Hui et al 2007;Hasi et al 2011). Recently, GWA studies further confirmed that this polymorphism is associated with the susceptibility to hypertension (Hiura et al 2010;Kato et al 2011).…”

Section: Traditional Cardiovascular Risk Factorsmentioning

confidence: 59%

The Glu504Lys Polymorphism of Aldehyde Dehydrogenase 2 Contributes to Development of Coronary Artery Disease

Sun

Shang

et al. 2014

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Coronary artery disease (CAD) is a leading cause of death, and its genetic mechanism has been always a major research concern. Recently, increasing evidence has indicated that the aldehyde dehydrogenase 2 (ALDH2) polymorphism, known as Glu504Lys (rs671), may contribute to CAD development. ALDH2 has been well known as a key enzyme in alcohol metabolism, and subjects with *504Lys allele exist in 30-50% of the East Asian population (6% of the world's population). However, recent studies have indicated that the *504Lys allele of the ALDH2 gene may be associated with the pathogenesis of CAD in a given number of Chinese, Japanese, and Korean people. This discovery has been further confirmed by a genome-wide association study in 2012 that identified the link of ALDH2 Glu504Lys polymorphism to CAD susceptibility. ALDH2 may therefore serve as an important target for CAD intervention. Several studies have suggested that ALDH2 polymorphism plays an important role in the progress of CAD through multiple mechanisms, including the regulation of alcohol consumption, inflammation, endothelial progenitor cells, oxidative stress, asymmetric dimethylarginine, endothelial nitric oxide synthase, and other CAD-promoting factors. Furthermore, the ALDH2 Glu504Lys polymorphism has been shown to be associated with certain traditional cardiovascular risk factors, such as dyslipidemia, hypertension, and diabetes mellitus or hyperglycemia. In this review, we update the current research on the association of the Glu504Lys polymorphism with the susceptibility to CAD. We also highlight and discuss the underlying mechanisms, by which the ALDH2 Glu504Lys polymorphism may be targeted for the prevention and treatment of CAD.

show abstract

Acetaldehyde dehydrogenase 2 SNP rs671 and susceptibility to essential hypertension in Mongolians: a case control study

Cited by 26 publications

References 14 publications

Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis

Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis

Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function

The Glu504Lys Polymorphism of Aldehyde Dehydrogenase 2 Contributes to Development of Coronary Artery Disease

Contact Info

Product

Resources

About