Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis

Wu, Yinyin; Ni, Juntao; Lian, Fuzhi; Ma, Haiyan; Xu, Liangwen; Yang, Lei

doi:10.1371/journal.pone.0177023

Cited by 21 publications

(21 citation statements)

References 32 publications

(31 reference statements)

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“…Finally, 22 articles (Takagi et al, 2001 ; Amamoto et al, 2002 ; Saito et al, 2003 ; Iwai et al, 2004 ; Hui et al, 2007 ; Hasi et al, 2011 ; Feng et al, 2012 ; Lv et al, 2013 ; Nakagawa et al, 2013 ; Wang et al, 2013 ; Wu et al, 2013 , 2017 ; Yokoyama et al, 2013 ; Zhang et al, 2013 , 2016 , 2018 ; Isomura et al, 2015 ; Jing et al, 2015 ; Ota et al, 2016 ; Li et al, 2017 ; Ma et al, 2017 ; Du, 2018 ) met the preset inclusion criteria. Among these articles, 20 (Takagi et al, 2001 ; Amamoto et al, 2002 ; Saito et al, 2003 ; Iwai et al, 2004 ; Hui et al, 2007 ; Hasi et al, 2011 ; Feng et al, 2012 ; Lv et al, 2013 ; Nakagawa et al, 2013 ; Wang et al, 2013 ; Wu et al, 2013 , 2017 ; Yokoyama et al, 2013 ; Jing et al, 2015 ; Ota et al, 2016 ; Zhang et al, 2016 , 2018 ; Li et al, 2017 ; Ma et al, 2017 ; Du, 2018 ) assessed the association between the rs671 polymorphism and EH risk in 30 individual studies (11,051 hypertensive patients and 15,926 normotensive controls), and 8 (Takagi et al, 2001 ; Amamoto et al, 2002 ; Saito et al, 2003 ; Wang et al, 2013 ; Zhang et al, 2013 ; Isomura et al, 2015 ; Ota et al, 2016 ; Li et al, 2017 ) assessed the association between the rs671 polymorphism and BP levels in 12 individual studies (20,512 subjects). The baseline characteristics of all included articles are summarized in Table 1 (for EH) and Table 2 (for BP).…”

Section: Resultsmentioning

confidence: 99%

“…Whether there is a relationship between the ALDH-2 rs671 polymorphism and hypertension remains unclear. Even previous meta-analysis studies on this issue have drawn different conclusions, and only focused on the association between ALDH-2 and essential hypertension risk (Jia et al, 2015 ; Li et al, 2017 ; Wu et al, 2017 ). In order to conclude the influence of the ALDH-2 rs671 polymorphism on hypertension, we performed a more comprehensive systematic review and meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

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Association Between ALDH-2 rs671 and Essential Hypertension Risk or Blood Pressure Levels: A Systematic Review and Meta-Analysis

et al. 2020

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Background: The association between Aldehyde dehydrogenase II (ALDH-2) rs671 polymorphism and essential hypertension (EH) risk or blood pressure (BP) levels remains unclear. Objective: To systematically review the influence of the aldehyde dehydrogenase II rs671 polymorphism on essential hypertension risk and blood pressure levels. Methods: The PubMed, EMbase, Web of Science, Cochrane Library, CNKI and CBM databases were electronically searched to identify case-control or cohort studies published prior to July 2019 that examined the association between the rs671 polymorphism and the risk of essential hypertension or blood pressure levels. A meta-analysis was conducted with Stata 15.1 software. Results: Twenty-two articles were included. Among these articles, 20 incorporated 30 individual studies evaluating the association between the rs671 polymorphism and EH (11,051 hypertensive patients and 15,926 normotensive controls), and 8 incorporated 12 individual studies evaluating the association between the rs671 polymorphism and BP (20,512 subjects). The results of the meta-analysis showed that the mutation of the rs671 polymorphism was associated with a significantly decreased risk of EH in all models: allelic model (OR = 0.80, 95% CI: 0.73–0.87), homozygous model (OR = 0.71, 95% CI: 0.63–0.80), heterozygous model (OR = 0.79, 95% CI: 0.72–0.87), dominant model (OR = 0.79, 95% CI: 0.71–0.87), and recessive model (OR = 0.76, 95% CI: 0.68–0.85). In the stratified analyses, significant associations were found for males, drinkers and population-based studies. Simultaneously, the A carriers had lower SBP (WMD = −1.78, 95% CI: −3.02 to −0.53) and DBP (WMD = −1.09, 95% CI: −1.58 to −0.61) levels than individuals with the GG homozygote. Conclusion: The collective findings of this meta-analysis suggested that the ALDH-2 rs671 polymorphism represented an important genetic marker in the development of hypertension. Considering the overall quality of evidence and the relatively small pooled sample size, more well-conducted high-quality studies are required to verify the above conclusion. Systematic Review Registration Number: PROSPERO (CRD42019129746).

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association Between ALDH-2 rs671 and Essential Hypertension Risk or Blood Pressure Levels: A Systematic Review and Meta-Analysis

et al. 2020

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“…Interestingly, several studies suggested that the rs671 L genotype was a protective factor in hypertension development. Wu Y 43 conducted case-control study and meta-analysis and indicated a decreased risk of hypertensive risk in AA/AG genotype. Zhang SY 18 found that the rs671 GG genotype was associated with an increased risk of hypertension compared with the AG/AA genotypes, especially in men and this association was independent of alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

Associations between aldehyde dehydrogenase 2 (ALDH2) rs671 genetic polymorphisms, lifestyles and hypertension risk in Chinese Han people

Zhang

et al. 2017

Sci Rep

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Hypertension is a multiple factor disease which was influenced by gene, environment, and lifestyle. Several studies confirmed that the ALDH2 rs671 polymorphism is associated with hypertension. However, the evidence remains inconclusive. Whether lifestyle affects blood pressure in different genotype groups have not been clarified, either. The subjects were adult Chinese Han people who received health examination in the period from December 2014 to December 2015. Detection of the ALDH2 r671 polymorphism was determined by polymerase chain reaction. Lifestyle data were collected using self-administered questionnaires. Basic characteristics and fasting venous blood sample were collected at baseline. 4018 subjects were eligible for participation.The frequencies of the ALDH2 rs671 genotype were 68.67% (GG), 28.67%(GL), 2.66%(LL), respectively. Pepole who harbored the L allele were less likely to develop incident hypertension. There was a significant association between food frequency and hypertension in the L genotype group. Fried food intake was significantly increased the risk of hypertension in the L genotype group. Our study suggested that ALDH2 rs671 L-genotypes are protective factors for hypertension in Han Chinese. Consumption of fried food accelerated the development of hypertension in individuals with poor metabolism of acetaldehyde.

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“…ALDH2 rs671 polymorphism genotyping was performed using polymerase chain reaction-ligase detection reaction (PCR-LDR) method (Generay Biotech Company, Shanghai, China). Primer sequences and reaction conditions used were described previously [ 17 ]. For quality control, we randomly chose 10% of the samples to re-genotype, and the concordance was 100%.…”

Section: Methodsmentioning

confidence: 99%

“…ALDH2 rs671 polymorphism exists mainly in the East Asian population, whereas it is quite rare in Caucasian and African population [ 12 ]. Accumulating evidence suggests that the ALDH2 rs671 polymorphism is associated with the risk of CAD in Asian population [ 8 , 13 – 16 ], and the mechanisms may relate to the effect of ALDH2 rs671 polymorphism on hypertension [ 17 – 19 ], dyslipidemia [ 13 , 20 , 21 ], and endothelial asymmetric dimethylarginine (ADMA) levels [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Interactions between ALDH2 rs671 polymorphism and lifestyle behaviors on coronary artery disease risk in a Chinese Han population with dyslipidemia: A guide to targeted heart health management

Huang

Lian

Zhang

et al. 2018

Environ Health Prev Med

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BackgroundBoth aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism and lifestyle behaviors are involved in coronary artery disease (CAD), while the interaction between them is currently unknown.MethodsA nested case-control study was conducted in 161 patients with CAD and 495 controls in dyslipidemia population in Yinzhou District, Ningbo, Zhejiang Province, China, in August 2013. Anthropometric data and blood samples were collected, demographic characteristics and lifestyle behaviors information were obtained by a face-to-face interview, dietary intake was assessed by a food frequency questionnaire, and genomic DNA was genotyped.ResultsCarriers with increasing number of A alleles had an elevated CAD risk compared with G allele carriers (adjusted OR = 1.483, 95% CI = 1.114–1.974). Carriers of rs671 A/G and A/A genotypes had a higher CAD risk than carriers of G/G genotype (adjusted OR = 1.492, 95% CI = 1.036–2.148). Similarly, individuals with rs671 A/A genotype had a higher CAD risk than individuals with A/G and G/G genotypes (adjusted OR = 2.161, 95% CI = 1.139–4.101). We found a borderline additive interaction between regular fried food intake and A/A and A/G genotypes, and a significantly additive interaction between sedentary/light physical activity and A/A and A/G genotypes.ConclusionsIndividuals with A/A or A/G genotypes of rs671 have a higher CAD risk, if they lack physical activity and take fried food regularly, than individuals with G/G genotypes. These findings can help to provide a guide to targeted heart health management.Electronic supplementary materialThe online version of this article (10.1186/s12199-018-0719-y) contains supplementary material, which is available to authorized users.

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Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis

Cited by 21 publications

References 32 publications

Association Between ALDH-2 rs671 and Essential Hypertension Risk or Blood Pressure Levels: A Systematic Review and Meta-Analysis

Association Between ALDH-2 rs671 and Essential Hypertension Risk or Blood Pressure Levels: A Systematic Review and Meta-Analysis

Associations between aldehyde dehydrogenase 2 (ALDH2) rs671 genetic polymorphisms, lifestyles and hypertension risk in Chinese Han people

Interactions between ALDH2 rs671 polymorphism and lifestyle behaviors on coronary artery disease risk in a Chinese Han population with dyslipidemia: A guide to targeted heart health management

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