Low intracellular magnesium levels promote platelet-dependent thrombosis in patients with coronary artery disease

Shechter, Michael; Merz, C. Noel Bairey; Rude, Robert K.; Labrador, Maura J. Paul; Meisel, Simcha; Shah, Prediman K.; Kaul, Sanjay

doi:10.1067/mhj.2000.107553

Cited by 51 publications

(39 citation statements)

References 27 publications

(31 reference statements)

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“…However, the processes that explain the link between reduced fetal growth and insulin resistance or glucose intolerance in adulthood are not fully understood. Mg 2ϩ deficiency occurs in adult patients with diabetes mellitus and vascular diseases (4,5). We also reported that children with diabetes and obesity have [Mg 2ϩ ] i deficiency (6).…”

Section: Resultsmentioning

confidence: 99%

Intracellular Magnesium and Adipokines in Umbilical Cord Plasma and Infant Birth Size

et al. 2007

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Many epidemiologic studies have disclosed that restricted fetal growth has been associated with an increased risk of insulin resistance in adulthood. We studied the relationship of intracellular magnesium ([Mg 2ϩ ] i ) in cord blood platelets to adipocytokine and birth size. The subjects were 20 infants with small for gestational age (SGA) and 45 infants with appropriate for gestational age (AGA). By using a fluorescent probe, we examined [Mg 2ϩ ] i of platelets in the cord blood. Cord plasma insulin, IGF-I, ghrelin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), and leptin levels were determined with the use of ELISA. Mean [Mg 2ϩ ] i was lower in the SGA than in the AGA groups (p Ͻ 0.001). Adiponectin and IGF-I were also lower in the SGA than in the AGA, whereas PAI-1 was higher in the SGA. [Mg 2ϩ ] i was significantly correlated with birth weight, birth length, and adiponectin. Birth weight was also correlated with cord plasma IGF-I, adiponectin, and leptin. Quantitative insulin sensitivity check index (QUICKI) was lower in the SGA group than in the AGA group. T here is no doubt that low birth weight is associated with adult disorders characterized by insulin resistance such as type 2 diabetes, hypertension, dyslipidemia, and coronary heart disease (1,2). It has been proposed that this association results from fetal programming in response to the intrauterine environment (3). Intracellular magnesium (Mg 2ϩ ) i deficiency occurs in patients with diabetes and vascular diseases (4 -6). Taken together, these experimental and epidemiologic results suggest that the correlation between Mg 2ϩ and birth weight are important determinants of insulin resistance. We and other investigators reported that insulin could regulate intracellular Mg 2ϩ ([Mg 2ϩ ] i ) in platelets (7,8). Platelets are often used in the study of cellular cation metabolism in diseases (9), because they are readily available for study and are thought to share a number of features with vascular smooth muscle cells. Human platelets have been shown to have insulin receptors with similar characteristics as those in other cells (10 ] i and birth weight (11). As the next step, we hypothesized that [Mg 2ϩ ] i may affect metabolic hormones and insulin resistance in infants. We studied the correlation among [Mg 2ϩ ] i , adipokines in cord blood and insulin resistance index. SUBJECTS AND METHODSThe study group consisted of 65 singleton subjects with gestational ages ranging from 33 to 41 wk, and birth weights ranging from 1332 to 4030 g. Most of these subjects had been previously recruited for an observational study of [Mg 2ϩ ] i (11). Gestational age was measured by dating the last menstrual period at the time of registration. None of the subjects were treated with medications, including magnesium, and did not show any evidence of endocrine malfunction or recent use of drugs that might potentially alter electrolyte balance. All the mothers were Japanese with no remarkable past medical histories, and they manifested no abno...

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Section: Resultsmentioning

confidence: 99%

Intracellular Magnesium and Adipokines in Umbilical Cord Plasma and Infant Birth Size

et al. 2007

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“…Reduced intracellular levels of Mg have been described in patients with acute myocardial infarction and also are significant as a regulator of platelet-dependent thrombosis. 17 Therefore, serum Mg is the most practicable and commonly used parameter for assessing disorders of Mg metabolism in clinical routine. 18 Recently, it has been demonstrated that low plasma levels of Mg accelerate atherogenesis by promoting inflammation and increasing LDL concentration and oxidative modification.…”

Section: Amighi Et Al Magnesium and Neurological Events 25mentioning

confidence: 99%

Low Serum Magnesium Predicts Neurological Events in Patients With Advanced Atherosclerosis

Amighi

Sabeti

Schlager

et al. 2004

Stroke

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Background and Purpose-Magnesium (Mg) deficiency is thought to be a risk factor for cerebrovascular atherosclerosis and complications. We investigated the prognostic impact of Mg serum levels with respect to the occurrence of neurological events in patients with advanced atherosclerosis. Methods-We prospectively studied 323 patients with symptomatic peripheral artery disease and intermittent claudication (197 men; median age, 68 years). Serum Mg was determined, and patients were followed for a median of 20 months (interquartile range, 12 to 25 months) for the occurrence of neurological events, defined as ischemic stroke and/or carotid revascularization (carotid endarterectomy or carotid stenting). Multivariate Cox proportional hazards analysis was applied to assess the association of serum Mg (in tertiles) and neurological events. Results-Neurological events occurred in 35 patients (11%) (15 patients with stroke, 13 with carotid revascularization, and 7 with stroke and subsequent revascularization

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“…Two studies reported lower levels of hair calcium or magnesium in women with postmenopausal or senile osteoporosis than in control groups, [27,28] consistent with our results. Studies on epilepsy, [18] hypertension, [26,29] atherosclerosis, [30] thrombosis in coronary heart disease, [31] breast and lung cancer, [32] premenstrual syndrome, [33] and mineral status in pregnant women [34] have shown that some minerals within individual cells or in tissues, rather than in blood, are more significant indicators.…”

Section: Discussionmentioning

confidence: 97%

Associations of Calcium and Magnesium in Serum and Hair with Bone Mineral Density in Premenopausal Women

Song

Barrett‐Connor

Chung

et al. 2007

Biol Trace Elem Res

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Low intracellular magnesium levels promote platelet-dependent thrombosis in patients with coronary artery disease

Cited by 51 publications

References 27 publications

Intracellular Magnesium and Adipokines in Umbilical Cord Plasma and Infant Birth Size

Intracellular Magnesium and Adipokines in Umbilical Cord Plasma and Infant Birth Size

Low Serum Magnesium Predicts Neurological Events in Patients With Advanced Atherosclerosis

Associations of Calcium and Magnesium in Serum and Hair with Bone Mineral Density in Premenopausal Women

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