Low-intensity focused ultrasound mediated localized drug delivery for liver tumors in rabbits

Abstract

ADM-NMCs combined with LIFU could inhibit the rabbits VX2 liver tumor progress by delaying the tumor proliferation and accelerating apoptosis, which presents a novel process for liver tumor targeting chemotherapy.

<div>Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging</div>

“…An LIFU instrument 23 (LM.SC051 ACA; Institute of Ultrasound Imaging of Chongqing Medical Sciences, Chongqing, People's Republic of China) with a driving frequency of 1.0 MHz, focal length of 1.5 cm, focus area of 0.4 cm 2 , acoustic intensity in a focal spot of 0.4-3.2 W/cm 2 , and 50% duty cycle was used in this study in a pulse wave (PW) mode with different acoustic intensities (0.8, 1.6, 2.4, and 3.2 W/cm 2 ) for 2 min. LIFU acoustic intensity was measured with a hydrophone (HNA-0400; ONDA Corp., Sunnyvale, CA, USA).…”

Increasing Distribution of Drugs Released from In Situ Forming PLGA Implants Using Therapeutic Ultrasound

“…11, 16, 32, 33 Several prior studies have examined the use of ultrasound to enhance drug release from polymer implants. 5, 6, 22 In contrast to the current study, these studies included gas bubbles or generation of heat, which were able to drive drug release via inertial cavitation and/or mild hyperthermia. Ultrasound exposure has also been shown to significantly increase degradation rate of the polymer matrix, especially polyanhydrides, or reform the structure of the polymer such as cross-link hydrogel or shape memory polymers.…”

“…11, 32, 33 In this process, typically it is the mechanical and thermal effects which are associated with an increase in penetration, perfusion or release of the drug. 6, 33 Recently ultrasound was also used to control release of insulin from a gel-like network system consisting of alginate-coated nanoparticles and chitosan-coated nanoparticles. During treatment with focused ultrasound, the network was deformed and promoted insulin release.…”

“…4 Low-intensity focused ultrasound is also used in number of applications to destroy gas-filled microbubbles, which leads to sonoporation and improved drug delivery parameter. 6 Building upon this body of research, our current work examines the feasibility of using ultrasound to enhance drug molecule transport from in situ forming implants and throughout the surrounding injection site, here tissue mimicking poly(acrylamide) gel phantoms.…”

Ultrasound microbubble-carried PNA targeting to c-myc mRNA inhibits the proliferation of rabbit iliac arterious smooth muscle cells and intimal hyperplasia

“…Contrast agent microbubbles combined with ultrasound-mediated targeted transfection of gene is a new, non-invasive, effective and convenient technique and can be used in the treatment of tumor or cardiovascular disease (Gong et al, 2014;Liao et al, 2014;Sun et al, 2014). Ultrasound-triggered microbubble destruction is considered as a method of target gene therapy for specific organ.…”