2015
DOI: 10.3109/10717544.2015.1014947
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Ultrasound microbubble-carried PNA targeting to c-myc mRNA inhibits the proliferation of rabbit iliac arterious smooth muscle cells and intimal hyperplasia

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Cited by 11 publications
(7 citation statements)
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“…The size of microbubbles (about 1-10 mm) enables them to circulate with red blood cells (Jayaweera et al, 1994;Sirsi and Borden, 2012;Mulvana et al, 2017). Microbubbles, as proven ultrasound-responsive materials, have been applied in drug delivery in clinical trials (Table 1) (Hynynen et al, 2001;Dimcevski et al, 2016;He et al, 2016). These clinical trials confirmed the controllability of delivering the cargo like drugs and gene materials with ultrasonic switch and visualization of treatment.…”
Section: Introductionmentioning
confidence: 83%
“…The size of microbubbles (about 1-10 mm) enables them to circulate with red blood cells (Jayaweera et al, 1994;Sirsi and Borden, 2012;Mulvana et al, 2017). Microbubbles, as proven ultrasound-responsive materials, have been applied in drug delivery in clinical trials (Table 1) (Hynynen et al, 2001;Dimcevski et al, 2016;He et al, 2016). These clinical trials confirmed the controllability of delivering the cargo like drugs and gene materials with ultrasonic switch and visualization of treatment.…”
Section: Introductionmentioning
confidence: 83%
“…Previous studies have shown that increased expression of c-MYC protein is closely associated with certain cardiovascular diseases, such as atherosclerosis, hypertension and restenosis 50 . c-MYC belongs to the basic helix-loop-helix leucine zipper (bHLHZip) family of transcription factors and can induce the continuous proliferation of VSMCs 51 - 53 . In this study, we demonstrated that inhibition of c-MYC expression was a key point for the anti-proliferative effect of celastrol in VSMCs.…”
Section: Discussionmentioning
confidence: 99%
“…Ultrasound-mediated drug delivery can be amplified by acoustic disruption of microbubbles (MB) that undergo cavitation (Escoffre et al, 2013). In recent years, MBs have been used successfully in preclinical research for drug delivery (Tsu-Yin et al, 2013;He et al, 2015). On the other hand, the nanoparticles can accumulate in the tumor tissue via a passive targeting mechanism known as the enhanced permeability and retention (EPR) effect (de Saint Victor et al, 2014).…”
Section: Introductionmentioning
confidence: 98%