Low holotranscobalamin and cobalamins predict incident fractures in elderly men: the MrOS Sweden

Lewerin, Catharina; Nilsson‐Ehle, Herman; Jacobsson, Stefan; Johansson, Helena; Sundh, Valter; Karlsson, Magnus K.; Ljunggren, Östen; Lorentzon, Mattias; Kanis, John А.; Lerner, Ulf H.; Cummings, Steven R.; Ohlsson, Claes; Mellström, Dan

doi:10.1007/s00198-013-2527-y

Cited by 7 publications

(6 citation statements)

References 41 publications

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“…Plasma total osteocalcin (carboxylated and uncarboxylated) was analysed using thawed frozen samples, with human monoclonal osteocalcin antibodies targeting the N‐terminal amino acids 1–43 and 1–49, and detected by electrochemiluminescence (Elecsys N‐MID Osteocalcin Cal‐Set; Roche Diagnostics, Indianapolis, IN, USA). Methods to analyse the concentrations of fasting serum insulin, fasting plasma glucose, serum leptin, adiponectin, P1NP, PTH, 25OHD, cystatin C, iron, transferrin, ferritin, total oestradiol, total testosterone, HDL cholesterol, holotranscobalamin (holo‐TC) and C‐reactive protein (CRP) and the plasma level of EPO have been described previously . Alkaline phosphatase (ALP) was analysed according to routine laboratory methods.…”

Section: Methodssupporting

confidence: 92%

High plasma osteocalcin is associated with low blood haemoglobin in elderly men: the MrOS Sweden Study

et al. 2016

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Section: Methodssupporting

confidence: 92%

High plasma osteocalcin is associated with low blood haemoglobin in elderly men: the MrOS Sweden Study

et al. 2016

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“…It has been suggested that diabetes may lead to falls by leading to diabetes-related visual impairment and peripheral neuropathy (27). In our study, DN4 scores were similar between both groups, Med J West Black Sea 2023;7(2): 202-210 peripheral neuropathy and poor locomotor function, therefore leading to falls (31). While Lewerin et al reported a weak association between vitamin B12 and physical performance, another study did not find a relationship between vitamin B12 and falls (31,32).…”

Section: Discussionsupporting

confidence: 58%

Osteoporozu Olan Geriatrik Kadın Hastalarda Düşme Öyküsü ve Düşme Korkusu ile İlişkili Faktörlerin Değerlendirilmesi

MENGİ,

SUALP

2023

Batı Karadeniz Tıp Dergisi

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Aim: Fear of falling is a common condition in patients with osteoporosis and leads to a decrease in physical performance of patients, causing a vicious cycle. The objective of the study was to determine the frequency of falls, descriptive data regarding falls, and factors associated with falling in female patients with osteoporosis aged 65 years and over, and to evaluate the factors that may affect fear of falling (FoF). Material and Methods: Ninety eight female patients (mean age: 74.0±5.1 years) were evaluated with descriptive information about fall history and FoF, demographic and clinical data, and routine blood tests. Falls Efficacy Scale International, hand grip strength, the Rivermead Mobility Index, and the Douleur Neuropathique 4 questionnaire scores were compared. Results: 25-hydroxyvitamin D, vitamin B12, and hand grip strength were lower and hemoglobin A1C level was higher in patients who fell within the last three months (p

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“…Low serum B12 levels affect DNA synthesis, an important factor for bone remodeling. Vitamin B12 (and other B vitamins—B2, B6 and folate—linked to homocysteine metabolism) is regarded an essential factor for bone health [ 117 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 ]. Vitamin B12 deficiency was reported to have an increased fracture risk: 1.7- to [ 162 ] 1.9-fold [ 163 ] for hip fracture, 1.8-fold for vertebral fracture [ 163 ] and 2.9-fold for distal forearm fracture [ 163 ].…”

Section: Hpi-induced Upper Gut Diseases and Osteoporotic Fracturesmentioning

confidence: 99%

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

Fisher

Smith

2020

JCM

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Osteoporosis (OP) and osteoporotic fractures (OFs) are common multifactorial and heterogenic disorders of increasing incidence. Helicobacter pylori (H.p.) colonizes the stomach approximately in half of the world’s population, causes gastroduodenal diseases and is prevalent in numerous extra-digestive diseases known to be associated with OP/OF. The studies regarding relationship between H.p. infection (HPI) and OP/OFs are inconsistent. The current review summarizes the relevant literature on the potential role of HPI in OP, falls and OFs and highlights the reasons for controversies in the publications. In the first section, after a brief overview of HPI biological features, we analyze the studies evaluating the association of HPI and bone status. The second part includes data on the prevalence of OP/OFs in HPI-induced gastroduodenal diseases (peptic ulcer, chronic/atrophic gastritis and cancer) and the effects of acid-suppressive drugs. In the next section, we discuss the possible contribution of HPI-associated extra-digestive diseases and medications to OP/OF, focusing on conditions affecting both bone homeostasis and predisposing to falls. In the last section, we describe clinical implications of accumulated data on HPI as a co-factor of OP/OF and present a feasible five-step algorithm for OP/OF risk assessment and management in regard to HPI, emphasizing the importance of an integrative (but differentiated) holistic approach. Increased awareness about the consequences of HPI linked to OP/OF can aid early detection and management. Further research on the HPI–OP/OF relationship is needed to close current knowledge gaps and improve clinical management of both OP/OF and HPI-related disorders.

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Low holotranscobalamin and cobalamins predict incident fractures in elderly men: the MrOS Sweden

Cited by 7 publications

References 41 publications

High plasma osteocalcin is associated with low blood haemoglobin in elderly men: the MrOS Sweden Study

High plasma osteocalcin is associated with low blood haemoglobin in elderly men: the MrOS Sweden Study

Osteoporozu Olan Geriatrik Kadın Hastalarda Düşme Öyküsü ve Düşme Korkusu ile İlişkili Faktörlerin Değerlendirilmesi

Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review)

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