High plasma osteocalcin is associated with low blood haemoglobin in elderly men: the Mr<scp>OS</scp> Sweden Study

Lewerin, Catharina; Johansson, Helena; Karlsson, Magnus K.; Lorentzon, Mattias; Lerner, Ulf H.; Kindblom, Jenny M.; Ohlsson, Claes; Smith, Ulf; Mellström, Dan

doi:10.1111/joim.12505

Cited by 4 publications

(3 citation statements)

References 45 publications

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“…Thus, hgb may affect bone mass in a way not captured by DXA. The association between hgb and osteocalcin has previously been reported by our group [37]. Adjusting for CRP did not change our results substantially.…”

Section: Discussionsupporting

confidence: 82%

High platelet count is associated with low bone mineral density: The MrOS Sweden cohort

et al. 2020

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Summary In elderly ambulatory men, high platelet and high neutrophil counts are related to low bone mineral density (BMD), after adjustment for relevant covariates. Low hemoglobin (hgb) is even associated with low BMD, but this relationship seems to be dependent on estradiol and osteocalcin. Purpose Blood and bone cells exist in close proximity to each other in the bone marrow. Accumulating evidence, from both preclinical and clinical studies, indicates that these cell types are interconnected. Our hypothesis was that BMD measurements are associated with blood count variables and bone remodeling markers. Methods We analyzed blood count variables, bone remodeling markers, and BMD, in subjects from the MrOS cohort from Gothenburg, Sweden. Men with at least one blood count variable (hgb, white blood cell count, or platelet count) analyzed were included in the current analysis ( n = 1005), median age 75.3 years (range 69–81 years). Results Our results show that high platelet counts were related to low BMD at all sites (total hip BMD; r = − 0.11, P = 0.003). No statistically significant association was seen between platelet counts and bone remodeling markers. Neutrophil counts were negatively associated with total body BMD ( r = − 0.09, P = 0.006) and total hip BMD ( r = − 0.08, P = 0.010), and positively related to serum ALP ( r = 0.15, P < 0.001). Hgb was positively related to total hip BMD ( r = 0.16, P < 0.001), and negatively to serum osteocalcin ( r = − 0.13, P < 0.001). The association between platelet and neutrophil counts and total hip BMD was statistically significant after adjustments for other covariates, but the association between hgb and total hip BMD was dependent on estradiol and osteocalcin. Conclusions Our observations support the hypothesis of an interplay between blood and bone components.

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Section: Discussionsupporting

confidence: 82%

High platelet count is associated with low bone mineral density: The MrOS Sweden cohort

et al. 2020

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“…Moreover, a correlation study in healthy older adults showed that plasma osteocalcin levels were positively associated with global cognitive performance in healthy women (Bradburn et al 2016). Interestingly, a recent, relatively extensive study showed an association between high blood osteocalcin levels and low serum hemoglobin in elderly men (Lewerin et al 2016). New knowledge of the interactions between bone and extraskeletal systems may signify a new approach, not only in the treatment of osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

Involvement of Bone in Systemic Endocrine Regulation

Žofková

2018

Physiol Res

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The skeleton shows an unconventional role in the physiology and pathophysiology of the human organism, not only as the target tissue for a number of systemic hormones, but also as endocrine tissue modulating some skeletal and extraskeletal systems. From this point of view, the principal cells in the skeleton are osteocytes. These cells primarily work as mechano-sensors and modulate bone remodeling. Mechanically unloaded osteocytes synthetize sclerostin, the strong inhibitor of bone formation and RANKL, the strong activator of bone resorption. Osteocytes also express hormonally active vitamin D (1,25(OH)2D) and phosphatonins, such as FGF23. Both 1,25(OH)2D and FGF23 have been identified as powerful regulators of the phosphate metabolism, including in chronic kidney disease. Further endocrine cells of the skeleton involved in bone remodeling are osteoblasts. While FGF23 targets the kidney and parathyroid glands to control metabolism of vitamin D and phosphates, osteoblasts express osteocalcin, which through GPRC6A receptors modulates beta cells of the pancreatic islets, muscle, adipose tissue, brain and testes. This article reviews some knowledge concerning the interaction between the bone hormonal network and phosphate or energy homeostasis and/or male reproduction.

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“…No adjustments were made for osteocalcin or estradiol in those studies (102)(103)(104). We have previously shown that in elderly men estradiol is positively and osteocalcin negatively correlated with Hb (171,172). Additionally, in the Italian and German studies, DXA was not used for assessing bone density but rather peripheral quantitative computerized tomography (pQCT) and ultrasound, respectively (102)(103)(104).…”

Section: Hemoglobin Neutrophil-and Platelet Countmentioning

confidence: 99%

Increased Risk of Hip Fracture in Patients with Lymphoma, a Swedish Population Study of 37,236 Lymphoma Patients

et al. 2020

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High plasma osteocalcin is associated with low blood haemoglobin in elderly men: the MrOS Sweden Study

Cited by 4 publications

References 45 publications

High platelet count is associated with low bone mineral density: The MrOS Sweden cohort

High platelet count is associated with low bone mineral density: The MrOS Sweden cohort

Involvement of Bone in Systemic Endocrine Regulation

Increased Risk of Hip Fracture in Patients with Lymphoma, a Swedish Population Study of 37,236 Lymphoma Patients

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