Low-Grade Sebaceous Carcinoma Presenting on the Leg

Imakado, Sumihisa; Hamada, Keisuke; Miura, Keiko

doi:10.1097/dad.0b013e31816bbd3a

Cited by 5 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To quantify the expression of D2-40, vascular endothelial growth factor, vascular endothelial growth factor receptor-2 and -3, we calculated a quantification score by considering the per-S ebaceous carcinoma (SC) represents a rare cutaneous adnexal neoplasm that may arise as ocular or extraocular SC (1). Extraocular SC is rare (25% of reported cases) and mostly affects the head and neck (2). According to a review including 1,349 cases of SC, the median age at diagnosis was 73 years, and a slight male predominance (54% men and 46% women) was noted (3).…”

Section: Significancementioning

confidence: 99%

Angiogenesis in Ocular and Extraocular Sebaceous Carcinoma

Toberer

Haenssle²,

Rütten³

et al. 2019

Acta Derm Venereol

View full text Add to dashboard Cite

centage of positive tumour cells (0=0%, 1=up to 1%, 2=2-10%, 3=11-50%, and 4=>50%) in relation to the staining intensity (0=negative, 1=low, 2=medium, and 3=strong). Additionally, lymphatic microvessel density in the D2-40 stained sections was counted. Vascular endothelial growth factor receptor-3 (quantification score 9.42 ± 2.94) was significantly more strongly expressed than vascular endothelial growth factor receptor-2 (quantification score 2.15 ± 2.42, p < 0.001). Furthermore, epidermal vascular endothelial growth factor expression was negatively correlated with the intratumoural lymphatic vessel density, and the ratio of small lymphatics to large lymphatics was much higher in intratumoural tissue than in paratumoural tissue and in intraindividual control tissue, suggesting a lymphangiogenetic potential of sebaceous carcinoma.

show abstract

Section: Significancementioning

confidence: 99%

Angiogenesis in Ocular and Extraocular Sebaceous Carcinoma

Toberer

Haenssle²,

Rütten³

et al. 2019

Acta Derm Venereol

View full text Add to dashboard Cite

show abstract

“…Sebaceous carcinoma is a rare cutaneous neoplasm that may manifest as ocular or extraocular [1]. Extraocular SC is rare (25 % of reported cases) and mostly affects the head and neck [2]. Regional lymph node metastases have been reported in both ocular and extraocular SC [1,3].…”

mentioning

confidence: 99%