Low-grade Sarcomas with CD34-Positive Fibroblasts and Low-Grade Myofibroblastic Sarcomas

Fisher, Cyril

doi:10.1080/019131290882187

Cited by 39 publications

(19 citation statements)

References 112 publications

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“…Based on these few cases, the biological course of abdominopelvic LGMS seems to be more aggressive than their superficially located soft tissue counterparts. Irrespective of multiple recurrences, metastases are extremely rare 16 17 20. Similar to a previous report,21 a changing morphology or a higher tumour grade may be observed in recurrent tumours and focal IMT-like areas may be seen.…”

Section: Discussionsupporting

confidence: 75%

Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review

et al. 2007

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Section: Discussionsupporting

confidence: 75%

Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review

et al. 2007

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“…37,47 However, the specific origin from myofibroblasts needs ultrastructural confirmation by demonstration of fibronexus and stress fibers. 16 Overall reactivity of canine PWT evidenced a phenotypic muscular continuum with intermediate phenotypes between HEP, myopericytomas, and angioleiomyomas that recapitulated the normal progressive variation in amount and type of contractile proteins distributed along the peripheral vascular beds. 46 Our findings paralleled the observation that some human PWT also derive from intermediate differentiation cell stages between pericytes, myopericytes, and smooth muscle cells.…”

Section: Discussionmentioning

confidence: 88%

“…Based on immunohistochemical staining, a phenotypic continuum from HEP to adventitial tumors was evidenced in 16 dogs (dog Nos. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. Contractile protein expression (Table 3) was minimal in the HEP; the amount increased in the group of myopericytomas, was maximal in the myomas, and was progressively reduced among the adventitial neoplasms recapitulating the phenotypic expression of these proteins in the normal vascular wall cell types.…”

Section: Immunohistologymentioning

confidence: 99%

The Spectrum of Canine Cutaneous Perivascular Wall Tumors: Morphologic, Phenotypic and Clinical Characterization

et al. 2007

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Perivascular wall tumors (PWTs) are defined as neoplasms deriving from mural cells of blood vessels, excluding the endothelial lining. The spectrum of human cutaneous PWT includes glomus tumor, hemangiopericytoma (HEP), myopericytoma, angioleiomyoma/sarcoma, angiomyofibroblastoma, and angiofibroma. The purpose of this study was to revise clinical presentation, cytology, histopathology, and immunohistology of canine cutaneous PWT with cytology typical of canine HEP. Diagnosis was established on the basis of vascular growth patterns (staghorn, placentoid, perivascular whorling, bundles from media) and immunohistology, including 7 smooth muscle markers and the cell membrane ganglioside of unknown origin recognized by the antibody 3G5 (CMG-3G5). Twenty cases were included. Ages ranged from 6 to 13 years; 12 dogs were males and 8 were females, and there was a prevalence of crossbreeds. Tumors arose from a single site with preferential acral location (10/20). Cytology revealed moderate to high cellularity in all cases, cohesive groups of cells (19/20), capillaries (18/20), and bi- to multinucleated cells (18/20). Six myopericytomas, 5 angioleiomyomas, 2 angioleiomyosarcomas, 2 HEP, 1 angiofibroma, and 1 adventitial tumor were identified. A definitive diagnosis was not possible in 3 cases. Smoothelin, heavy caldesmon, desmin, myosin, calponin, and CMG-3G5 were the most valuable markers to differentially diagnose canine PWT. Similar to reports in humans, canine HEP embodied a spectrum of neoplastic entities arising from different vascular mural cells. Before canine PWTs are assimilated into one prognostic category, a consistent classification and characterization of their biology is necessary. As proposed in humans, HEP should also be considered a diagnosis of exclusion in dogs.

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“…Support for the clonal nature of this neoplasm has been furthered by the finding of chromosomal changes involving 2p23 with different fusion transcripts, including TPM3-ALK and TPM4-ALK (14)(15)(16). Variable involvement for the ALK gene has been reported at other anatomic sites (17,18), but most cases reported in the uterus have been positive for ALK gene rearrangement (8,19).…”

mentioning

confidence: 99%

Inflammatory Myofibroblastic Tumor of the Placenta

Banet

Ning

Montgomery

2015

International Journal of Gynecological Pathology

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Inflammatory myofibroblastic tumor has been described in a wide variety of anatomic sites, although in the gynecologic tract, it has mostly been documented in the uterus, and has never been described in the placenta. Two patients presented with well-circumscribed placental masses that showed classic histologic features of inflammatory myofibroblastic tumor including a proliferation of myofibroblastic cells, a mixed inflammatory infiltrate, and a myxoid background. One case was positive by immunohistochemistry for anaplastic lymphoma kinase (ALK-1), whereas the other was negative by immunohistochemistry and fluorescent in situ hybridization. Inflammatory myofibroblastic tumors should be differentiated from other more aggressive uterine tumors that may involve the placenta by direct extension/metastasis because they can be managed conservatively, and in these 2 cases, did not seem to affect the course of the patient's pregnancies.

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Low-grade Sarcomas with CD34-Positive Fibroblasts and Low-Grade Myofibroblastic Sarcomas

Cited by 39 publications

References 112 publications

Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review

Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review

The Spectrum of Canine Cutaneous Perivascular Wall Tumors: Morphologic, Phenotypic and Clinical Characterization

Inflammatory Myofibroblastic Tumor of the Placenta

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