Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review

Agaimy, Abbas; Wünsch, Peter H.; Schroeder, Josef; Gäumann, Andreas; Dietmaier, Wolfgang; Hartmann, Arndt; Hofstaedter, Ferdinand; Mentzel, Thomas

doi:10.1136/jcp.2007.048561

Cited by 24 publications

(14 citation statements)

References 36 publications

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“…The tumours range in size from 1.5 to 17 cm and occur most commonly in the head and neck region, including the oral cavity, pharynx and parapharyngeal regions, proximal extremities and trunk, with occasional cases in the abdomen or pelvis 104. Visceral lesions are rare.…”

Section: Malignant Myofibroblastic Lesionsmentioning

confidence: 99%

The myofibroblast and its tumours

et al. 2008

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Tumours and tumour-like lesions of myofibroblasts may present diagnostic difficulty because of their rarity and because of uncertainties in identifying the myofibroblast. The objectives of this review are to provide a definition of the myofibroblast and an account of its biology for facilitating an understanding of the cell and of myofibroblastic lesions; and to describe, in the context of common diagnostic problems, the features of benign and malignant myofibroblastic lesions. The main characteristics of the myofibroblast include a spindled or stellate morphology; immunostaining for alpha-smooth muscle actin and the extra domain A variant of cellular fibronectin; and an ultrastructure of rough endoplasmic reticulum, peripheral contractile filaments and the cell-to-matrix junction known as the fibronexus. On this basis, lesions traditionally regarded as myofibroblastic are shown to vary in their level of differentiation, and some appear to be smooth muscle rather than myofibroblastic. Immunohistochemistry and electron microscopy, used together, are emphasised as being important for maximum diagnostic confidence in some myofibroblastic lesions.

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Section: Malignant Myofibroblastic Lesionsmentioning

confidence: 99%

The myofibroblast and its tumours

et al. 2008

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“…Low-grade myofibroblastic sarcoma (LGMS) represents a rare entity, which mostly develops in the soft tissues of the head and neck [1]. Within the oral cavity lingual lesions are the most common [2,3] and they tend to recur locally rather than to metastasise.…”

Section: Introductionmentioning

confidence: 99%

Low-grade myofibroblastic sarcoma of the mandible: a case report

Niedzielska

Janic

Mrowiec³

2009

J Med Case Rep

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IntroductionLow-grade myofibroblastic sarcoma is a rare entity, which mostly develops in the soft tissues of the head and neck. Within the oral cavity lingual lesions are the most common. It tends to recur locally rather than to metastasise.Case presentationWe present a 54-year-old man with a one-year history of buccal oedema. He also had arterial hypertension and clinical examination revealed distension of the left mandibular ramus with laminar deflection in the area of the retromolar triangle.ConclusionWe present a rare intramandibular encapsulated lesion that caused diagnostic difficulties. Our diagnostic methods included immunohistochemistry and molecular investigations. We emphasise the uncommon location of this tumour type.

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“…The diagnosis of myofibroblastic tumor is difficult due to their rarity and the uncertainties in identifying the myofibroblast (2). The attributes of a myofibroblast place it midway between a smooth muscle cell and a fibroblast with defining ultrastructural markers of both cell types, i.e., the myofilaments and fibronectin fibrils (1, 3). Myofibroblasts are not a constituent of normal untraumatized tissues but rather predominate under conditions of trauma (wound‐healing) or abnormality (inflammatory and reactive conditions) (2).…”

Section: Discussionmentioning

confidence: 99%

47‐year‐old Man With Frontal Lobe Tumor

Zhang¹,

Zhu

et al. 2011

Brain Pathology

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A 47 year-old man presented with left extremity weakness for 1 year, which had worsened significantly over the past 40 days. 23 years ago he suffered head trauma with loss of consciousness for 30 minutes and was diagnosed with a concussion. Two weeks later he had his first generalized seizure, and continued to have about one seizure per week. His seizures were not well-controlled on phenytoin. Fifteen years ago, the patient underwent brain CT scan, revealing right frontal encephalomalacia (Figure 1c). Epilepsy surgery was performed and silver clips were deployed for hemostasis. Following the surgery and change of medications to carbamazepine he continued to suffer seizures about one or twice a month. At this current presentation for left extremity weakness, the neurological examination discovered decreased muscle strength of the left side. CT scan revealed a huge hypodense lesion in the right frontal lobe with remarkable mass effect (Figure 1a), but without distinct contrast-enhancement (Figure 1b). Hyperdense foci could be seen within the mass, which were ascertained to be the silver clips used in his surgery. MRI scan could not be performed due to these clips. A right frontal craniotomy was performed and a large tumor was removed and submitted for pathology.

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Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature review

Abstract: Abdominopelvic LGMS follows a more aggressive clinical course characterised by a higher propensity for local recurrence, contrasting their more superficially located counterparts. LGMS may mimic a variety of benign and low-grade malignant neoplasms and might be under-recognised.

Cited by 24 publications

References 36 publications

The myofibroblast and its tumours

The myofibroblast and its tumours

Low-grade myofibroblastic sarcoma of the mandible: a case report

47‐year‐old Man With Frontal Lobe Tumor

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