Low-grade myofibroblastic sarcoma of the palm

Nagata, Yasunobu; Matsuno, Takahiro; Hamada, Norikazu; Shimose, Shoji; Arihiro, Koji; Ochi, Mitsuo

doi:10.1080/02844310601029977

Cited by 7 publications

(9 citation statements)

References 5 publications

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“…LGMS has been reported at a variety of sites, including the extremities ( 17 , 18 ), trunk ( 19 , 20 ) and abdominal and pelvic cavities ( 21 , 22 ). However, the malignancy is usually associated with the head and neck, particularly the tongue ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Low-grade myofibroblastic sarcomas of the maxilla

et al. 2014

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Low-grade myofibroblastic sarcoma (LGMS) is a distinct mesenchymal myofibroblastic malignancy. The tumor may occur at a variety of sites, but is particularly associated with the head and neck. Of the two maxillary sarcomas that were analyzed in the present study, one was misdiagnosed as an inflammatory myofibroblastic tumor during pre-operative excision biopsy, and later presented with a different immunophenotype upon recurrence. Representative paraffin blocks from formalin-fixed tissues were selected from each patient and designated as case 1 and case 2. Immunohistochemical studies were performed on 3-μm thick sections using primary antibodies against α-smooth muscle actin (α-SMA), muscle-specific actin (MSA), desmin, vimentin, calponin, h-caldesmon, fibronectin, cytokeratin, cluster of differentiation 34 (CD34), S-100 protein, anaplastic lymphoma kinase (ALK), epithelial membrane antigen (EMA) and Ki-67. Immunohistochemistry was performed using the streptavidin-biotin-peroxidase complex method. The tumor cells from the two maxillary LGMSs, including the recurrent lesion, were positive for vimentin and fibronectin, and negative for S-100 protein, CD34, EMA, h-caldesmon, ALK, MSA and calponin. The tumor cells from case 1 demonstrated positive staining for α-SMA protein and negative staining for desmin. By contrast, the tumor cells from the primary lesion in case 2 presented with negative staining for α-SMA and positive staining for desmin, while the cells of the recurrent lesion were α-SMA-positive and desmin-negative. The present study concluded that cases of LGMS with immunoprofile alterations are predictive of relatively poor prognoses.

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Section: Introductionmentioning

confidence: 99%

Low-grade myofibroblastic sarcomas of the maxilla

et al. 2014

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“…19 cases were localized in the soft tissue, 15 cases in the bones with predilection of the distal femur. We identi ed only 2 case of LGMS in the hand, one of them in the distal phalanx of the nger and another one in the soft tissue of the palm [16,17]. All patients were treated surgically, either with wide resection or local excision, and 8 of them received an additional adjunctive therapy.…”

Section: Resultsmentioning

confidence: 99%

Low-Grade Myofibroblastic Sarcoma (LGMS) of the Extremities – A Systematic Review and Case Report

Schenker¹,

Lehner²,

Gutjhar³

et al. 2020

Preprint

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Background: Low-grade myofibroblastic sarcoma (LGMS) is a rare subtype of soft tissue sarcoma of intermediate grade often representing fibromatosis-like features with a rare metastasing behavior. This type of tumor has a predilection for the head and neck region, but also occurs in the extremities. Confirming the diagnosis is difficult and treatment strategies have to be chosen individually.Methods: The objective of this study was to conduct a systematic review for LGMS of the extremities. The electronic databases PubMed and the Cochrane Library were searched for eligible studies. 141 abstracts were screened on PubMed, while 10 studies were identified as eligible. Cases were summarized in terms of clinical aspects, therapeutic regimen with the primary endpoint of follow-up controls regarding local recurrence or distant metastasis. In addition, we present the rare case and surgical management of a 28-year-old male patient with residual LGMS of the thumb after initial incomplete resection. Results: 33 cases of LGMS in the extremities were identified on PubMed. Cochrane library didn’t show any results. All of them were surgically resected. Only two cases of LGMS in the hand were described in literature so far. Treatment options varied from local excision to wide resection without exact definition of the safety distance. 26 cases provided follow-up information with local recurrence in 6 cases (23 %), while 4 cases (15 %) showed distant metastasis. Conclusions: Wide resection should be the surgical aim to avoid local recurrence and distant metastases. While the excision of tumors of the thumb and hand often require closer resection margins, due to the close proximity of anatomical structures, tumor-free margins are elementary even if tissue transfer from a donor site is needed for reconstruction.

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“…LGMS is a recently defined tumor that can be considered a part of the spectrum of malignant mesenchymal tumors, showing features of myofibroblastic differentiation 11) . Myofibroblasts have been recognized for over three decades, but the existence of sarcomas composed of myofibroblasts has become generally accepted recently 8) . Myofibroblastic sarcoma must be distinguished from other neoplasms, which including nodular fasciitis, proliferative myositis and fibromatosis, and also other types of low-grade spindle-cell sarcomas, leiomyosarcoma and fibrosarcoma 10) .…”

Section: Discussionmentioning

confidence: 99%

“…LGMS tumors cells express strong positive immunoreactivity for at least one of following myogenic markers that muscle-specific actin (HHF35), α-smooth muscle actin, rarely desmin 1 7 8 11 12) . LGMS may also express focal expression of CD34 and CD99 8) . The tumors do not stain for S-100 protein, epithelial markers such as laminin and h-caldesmon 4 8 12) .…”

Section: Discussionmentioning

confidence: 99%

“…Myofibroblasts are spindle mesenchymal cells sharing features of both muscular and fibroblastic cells 6) and represent a connective tissue cell characterized by morphologic and functional properties intermediate between fibroblasts and smooth muscle cells 3) . Low-grade myofibroblastic sarcoma (LGMS) represents a distinct atypical myofibroblastic tumor with fibromatosis like features and has a predilection for the head and neck, particularly the tongue and oral cavity 2 8) . More than 80% of malignant tumors of the head-and-neck region originate from squamous epithelium.…”

Section: Introductionmentioning

confidence: 99%

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Low Grade Myofibroblastic Sarcoma Occurred in the Scalp

Han

Yee

2015

J Korean Neurosurg Soc

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Low-grade myofibroblastic sarcoma (LGMS) is a rare sarcoma with myofibroblastic differentiation. LGMS has a propensity for local recurrence and is associated with a low risk of metastatic spread. A 26-year-old man presented with a 12-month history of a slow growing palpable hard mass in the right parietal scalp. Enhanced CT scan of head showed a 3×4 cm sized well-defined and heterogeneously enhancing scalp mass. The patient underwent excision of the tumor. The histological and immunohistochemical features were consistent with a LGMS. We performed re-operation for remnant tumor removal after diagnosis. After 14 months of surgery, the patient was well-being state.

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Low-grade myofibroblastic sarcoma of the palm

Cited by 7 publications

References 5 publications

Low-grade myofibroblastic sarcomas of the maxilla

Low-grade myofibroblastic sarcomas of the maxilla

Low-Grade Myofibroblastic Sarcoma (LGMS) of the Extremities – A Systematic Review and Case Report

Low Grade Myofibroblastic Sarcoma Occurred in the Scalp

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