Low-grade endotoxemia, gut permeability and platelet activation in community-acquired pneumonia

Cangemi, Roberto; Pignatelli, Pasquale; Carnevale, Roberto; Bartimoccia, Simona; Nocella, Cristina; Falcone, Marco; Taliani, Gloria; Violi, Francesco; Battaglia, S; Bertazzoni, Giuliano; Biliotti, Elisa; Calabrese, C; Casciaro, Marco; Angelis, Maurizio De; Marzio, Paolo De; Esvan, Rozenn; Fazi, Lucia; Ferro, Domenico; Šuleková, Lucia Fontanelli; Franchi, Cristiana; Giordo, Laura; Grieco, Stefania; Manzini, Elisa; Morelli, Sergio; Palange, Paolo; Pastori, Daniele; Capparuccia, Marco Rivano; Romiti, Giulio Francesco; Rossi, Elisabetta; Ruscio, Eleonora; Russo, Alessandro; Scarpellini, Maria Gabriella; Trapè, Stefano; Toriello, Filippo

doi:10.1016/j.jinf.2016.05.013

Cited by 50 publications

(43 citation statements)

References 31 publications

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“…sP-selectin is also more abundant in the blood (serum and plasma) of patients with severe chronic venous insufficiency [70]. In community-acquired pneumonia plasma sP-selectin is increased [71] and predicts the occurrence of myocardial infarction [72]. Platelet P-selectin is associated with hypertension [73]; in patients with hypertension caused by primary aldosteronism serum, sP-selectin decreased after removal of aldosterone-secreting adrenal adenoma [74].…”

Section: Discussionmentioning

confidence: 99%

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Nowak

Wojsyk‐Banaszak

Mądry

et al. 2017

Lung

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PurposeAs life expectancy in cystic fibrosis (CF) increases, questions regarding its potential impact on cardiovascular health arise. Soluble vascular cell adhesion molecule 1 (sVCAM-1), P-selectin (sP-selectin) are proposed as biomarkers of cardiovascular disease. We aimed to: compare their concentrations in clinically stable CF patients and healthy subjects (HS) and verify whether they independently correlate with CF characteristics.MethodsSerum sVCAM-1 and sP-selectin levels were measured using ELISA. CF was characterized using: forced expiratory volume in 1 s, exocrine pancreatic and CF-related liver disease status, Pseudomonas aeruginosa colonization, serum high-sensitivity C-reactive protein, and body mass index (BMI). CFTR genotypes were classified as severe (classes I and II) or other.Results108 CF patients and 51 healthy subjects volunteered for the study. In the CF group BMI was lower (median [IQR]: 20.5 kg/m2 [18.4–22.2] vs. 21.6 kg/m2 [19.9–23.4], p = 0.02) and hsCRP levels were higher (3.6 mg/L [1.1–7.1] vs. 0.5 mg/dL [0.3–1.0], p < 10−10). While sVCAM-1 concentrations were greater in CF patients (1018 ng/mL [851–1279] vs. 861 ng/mL [806–979], p < 10−4), sP-selectin levels did not differ (155 ng/mL [129–188] vs. 156 ng/mL [144–177], p = 0.48). None of the multivariable regression models was valid for the prediction of sVCAM-1 and sP-selectin in CF.ConclusionsWe found higher sVCAM-1 concentrations in CF patients than in healthy subjects, which were not explained by CF characteristics. Further research is required to check whether sVCAM-1 is a marker of microangiopathy in CF.

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Section: Discussionmentioning

confidence: 99%

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Nowak

Wojsyk‐Banaszak

Mądry

et al. 2017

Lung

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“…Twenty‐four studies reported on 29 statistically significant biomarkers and association with altered IP . Two studies reported that fasting glucose had a weak positive correlation with IP (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…Two studies used both zonulin and the dual sugar test and reported a high positive correlation between the two tests ( ρ = 0.891; P = 0.05) (Table ). However, mixed evidence was reported for the strength of association between zonulin and LPS with a weak to moderate positive correlation reported ( ρ = 0.545; P < 0.001); although, one study reported LPS to independently correlate with zonulin levels ( β = 0.002; 95% CI: 0.001, 0.003; P = 0.002) (Table ). The dual sugar test was also reported to have a moderate to high positive correlation with gastroduodenal permeability according to one study ( r = 0.68; P < 0.0001, r = 0.88; P < 0.0001) …”

Section: Resultsmentioning

confidence: 99%

“…Twenty-four studies reported on 29 statistically significant biomarkers and association with altered IP. 10,23,25,32,35,[40][41][42][43][44][50][51][52][53][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72] Two studies reported that fasting glucose had a weak positive correlation with IP 44,53 (Table 5). Moreover, an additional study reported that a plasma glucose level >5.7 nmol/L is associated with a greater odds of having altered IP (OR = 2.09; 95% CI: 2.09, 4.18; P = 0.036) in the general population 23 (Table 3).…”

Section: Biomarker Risk Factorsmentioning

confidence: 99%

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Risk factors associated with intestinal permeability in an adult population: A systematic review

et al. 2019

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Background Increased intestinal permeability (IP) involves the loss of integrity between the cells of the small intestine. IP has been suggested to contribute to the pathogenesis and exacerbation of many chronic diseases. Many potential risk factors for IP are proposed in contemporary literature. The purpose of this review is to identify the most significant risk factors for IP. Methods A systematic search of literature published up until September 2018 in the PubMed, EMBASE, CINAHL, and Scopus databases was conducted. Results A total of 47 articles met the inclusion criteria. Elevated levels of proinflammatory markers, dyslipidaemia, hyperglycaemia, insulin resistance, anthropometric measurements resembling obesity, advanced disease severity, comorbidity and the consumption of a Western‐style diet were identified as the strongest risk factors for altered intestinal integrity. The risk of IP increases when coupled with a multiple disease state or combined with other environmental risk factors. Furthermore, many of the identified risk factors such as anthropometric measurements and biomarkers were external from intestinal health and rather resembled a metabolic‐like condition. Conclusions This review identified a number of potential risk factors for IP, ranging from biomarkers to anthropometric measurements, demographics, dietary intake and chronic diseases. These risk factors warrant the attention of clinicians and other healthcare providers to aid the identification of potential patients at risk of altered IP. Further research needs to examine whether the identified risk factors are homogeneous with the diagnosis of IP or whether the disease state influences the association.

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“…Although the association of infectious agents (herpes virus and gram-positive bacteria) with BD pathogenesis has been reported, our results suggest a possible role for LPS in the pathogenesis of BD. Increased LPS concentration in serum is observed in community-acquired pneumonia usually caused by viruses or gram-positive bacteria, and is reported to contribute to the pathogenesis of pneumonia via NOX2 activation8.…”

Section: Resultsmentioning

confidence: 99%

Transcription Factors Regulating Inflammatory Cytokine Production Are Differentially Expressed in Peripheral Blood Mononuclear Cells of Behçet Disease Depending on Disease Activity

et al. 2017

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BackgroundBehçet disease (BD) is a relapsing inflammatory disease with increased production of inflammatory cytokines in peripheral blood mononuclear cells (PBMCs); however, the underlying molecular mechanisms are not well known.ObjectiveTo analyze whether the differential expression of transcription factors is involved in the increased tumor necrosis factor (TNF)-α and interleukin (IL)-6 production by PBMCs of BD patients compared to healthy controls (HCs).MethodsExpression of transcription factors was examined by real-time reverse transcriptase-polymerase chain reaction and western blotting. Cytokine production by CD11b+ cells transfected with siRNAs against transcription factors was measured by enzyme-linked immunosorbent assay.ResultsIn the absence of lipopolysaccharide stimulation, the transcript level of CCAAT-enhancer-binding proteins (C/EBP) β was increased in PBMCs from patients with active BD compared to that in PBMCs from patients with stable BD. The C/EBPδ transcript level was higher in PBMCs from patients with active BD than in those from HCs. The activating transcription factor 3 (ATF3) transcript level was increased in PBMCs from patients with stable BD compared to that in PBMCs from HCs. siRNAs targeting C/EBPβ and C/EBPδ significantly reduced the production of IL-6 and TNF-α in lipopolysaccharide-stimulated CD11b+ cells from patients with BD as well as from HCs.ConclusionWe found differential expression of C/EBPβ, C/EBPδ, and ATF3 in PBMCs from patients with BD depending on disease activity, indicating the involvement of these molecules in BD pathogenesis.

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Low-grade endotoxemia, gut permeability and platelet activation in community-acquired pneumonia

Cited by 50 publications

References 31 publications

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Risk factors associated with intestinal permeability in an adult population: A systematic review

Transcription Factors Regulating Inflammatory Cytokine Production Are Differentially Expressed in Peripheral Blood Mononuclear Cells of Behçet Disease Depending on Disease Activity

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