‘Low-grade’ astroblastoma with rapid recurrence: a case report

Lau, Patrick S. Y.; Thomas, Teresa M. M.; Lui, Pauline Po Yee; Khin, Aye T.

doi:10.1080/00313020500468871

Cited by 21 publications

(20 citation statements)

References 6 publications

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“…describe low-grade astroblastomas treated with GTR that recurred at 12 and 20 months, respectively, warranting another operation followed by adjuvant radiotherapy. [1221] Similarly, our patient had little peritumoral edema on imaging and a staining profile consistent with a low-grade tumor. Nevertheless, on follow-up she demonstrated signs of recurrence, including diffuse leptomeningeal spread on imaging, for which adjuvant radiotherapy was pursued.…”

Section: Discussionmentioning

confidence: 58%

“…[812] The absence of these features in the present case helped guide our initial decision for gross total resection in the setting of a low-grade tumor. However, such prognostic criteria are not always reliable.…”

Section: Discussionmentioning

confidence: 82%

“…Since then, multiple articles have been published showcasing a variable biological behavior of astroblastoma tumors. [111219] The 2007 update of the WHO classification describes astroblastoma as a neuroepithelial tumor of unknown origin, but was again unable to assign a proper grade. [13] The most recent revision describes astroblastoma as a high-grade (grade 4) neuroepithelial tumor of unknown origin.…”

Section: Introductionmentioning

confidence: 99%

“…[9] Despite this, controversy persists as more recent works analyzing long-term data demonstrate a 95% survival rate following gross total resection. [31220] There are no established guidelines for the treatment of astroblastomas, and therapy has ranged from radiotherapy alone to subtotal resection to gross total resection with or without adjuvant chemo/radiation. The lack of knowledge and consensus regarding therapeutic modalities create problems when attempting to provide timely and appropriate treatment for these rare tumors.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A case of astroblastoma: Radiological and histopathological characteristics and a review of current treatment options

Samples¹,

Henry²,

Bazán³

et al. 2016

Surg Neurol Int

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Background:Astroblastoma is a rare neuroepithelial tumor that often originates in the cerebral hemisphere of children and young adults. Diagnosis of this obscure neoplasm can be difficult because these tumors are so infrequently encountered and share common radiological and neuropathological features of other glial neoplasms. As such, it should be included in the differential diagnosis of astrocytoma and ependymoma if the clinical and radiographic features suggest it. Standardized treatment of astroblastomas remains under dispute because of the lack of knowledge regarding the tumor and a paucity of studies in the literature.Case Description:We present a case of a low-grade astroblastoma diagnosed in a 30-year-old female with seizures, headache, and vision changes. She underwent gross total resection and, without evidence of high-grade features, adjuvant therapy was not planned postoperatively. Post-operative surveillance suggested early recurrence, warranting referral to radiation therapy. Patient ended up expiring despite adjuvant therapy secondary to extensive recurrence and tumor metastasis.Conclusions:Astroblastoma must be considered in the differential of supratentorial tumors in children and young adults. Treatment of such, as suggested by most recent literature, includes gross total resection and adjuvant radiotherapy for lesions exhibiting high-grade features.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 82%