Low Gastric Hydrochloric Acid Secretion and Mineral Bioavailability

Champagne, Elaine T.

doi:10.1007/978-1-4684-9111-1_12

Cited by 51 publications

(24 citation statements)

References 33 publications

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“…Gastric acid facilitates the absorption of non-heme iron by reducing ferric iron to the more soluble ferrous form [23,24]. Gastric acid also enhances iron salt dissociation from ingested food and allows formation of complexes with amines and sugars that also increase absorption.…”

Section: Iron Deficiencymentioning

confidence: 96%

Adverse Effects of Long-Term Proton Pump Inhibitor Therapy

2011

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Proton pump inhibitors have an excellent safety profile and have become one of the most commonly prescribed class of drugs in primary and specialty care. Long-term, sometimes lifetime, use is becoming increasingly common, often without appropriate indications. This paper is a detailed review of the current evidence on this important topic, focusing on the potential adverse effects of long-term proton pump inhibitor use that have generated the greatest concern: B12 deficiency; iron deficiency; hypomagnesemia; increased susceptibility to pneumonia, enteric infections, and fractures; hypergastrinemia and cancer; drug interactions; and birth defects. We explain the pathophysiological mechanisms that may underlie each of these relationships, review the existing evidence, and discuss implications for clinical management. The benefits of proton pump inhibitor use outweigh its risks in most patients. Elderly, malnourished, immune-compromised, chronically ill, and osteoporotic patients theoretically could be at increased risk from long-term therapy.

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Section: Iron Deficiencymentioning

confidence: 96%

Adverse Effects of Long-Term Proton Pump Inhibitor Therapy

2011

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“…This latter study needs careful interpretation since acidity is required for the dissolution of antacids and again these results probably show that more A1 is solubilized from antacids at the lower pH, and not that acid itself increases the absorption of Al. So there is little evidence to suggest that an elevated proton concentration in the stomachbowel increases A1 absorption, but rather that, like Fe (Champagne, 1988), a more acidic gastric environment may help to solubilize more of the ingested Al. Clearly the gastric solubility of A1 depends largely on the form in which it is ingested.…”

Section: Gastrointestinal Acidity and T H E Form O F Ingested Aluminiummentioning

confidence: 99%

The chemistry of aluminium in the gastrointestinal lumen and its uptake and absorption

Powell

Thompson

1993

Proc. Nutr. Soc.

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A large number of experimental studies have been carried out on the intestinal absorption and/or uptake of Al, and on the factors that affect this. However, apart from the well-known problems of contamination and the difficulty of analysis of Al, many of these studies have been flawed, particularly when experimental solutions have been used, since often it has not been realized that the A1 has precipitated at physiological pH. Other problems have included inappropriate use of buffers (such as containing phosphate) and extrapolation of results from unphysiologically high levels to dietary levels.Here we shall assess the chemistry, uptake and absorption of A1 from the gastrointestinal tract, and in particular consider the importance of dietary, rather than pharmacological, levels to which the general population is exposed.

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“…Gastric acid is required in order to maintain the common ferric form of inorganic iron soluble, and achlorhydria may be a significant cause of iron deficiency in the elderly. Perhaps 30% of the elderly have achlorhydria [26]. Gastric atrophy and Helicobacter pylori gastric infestation may result in altered pH and iron deficiency [27].…”

Section: Introductionmentioning

confidence: 99%

Iron deficiency: A concise review

2005

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Iron deficiency is a major worldwide health problem. There is recent evidence that the anemia is only the last manifestation of the syndrome and that symptoms occur before the anemia is manifest. Advances in outlining the physiology of iron deficiency have been made, gaps remain in the current understanding. While oral iron supplement remains the mainstay, some indications for the intravenous administration have developed. This review will highlight the epidemiology, physiology, clinical presentation, and treatment options. Am.

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Low Gastric Hydrochloric Acid Secretion and Mineral Bioavailability

Cited by 51 publications

References 33 publications

Adverse Effects of Long-Term Proton Pump Inhibitor Therapy

Adverse Effects of Long-Term Proton Pump Inhibitor Therapy

The chemistry of aluminium in the gastrointestinal lumen and its uptake and absorption

Iron deficiency: A concise review

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