Iron deficiency: A concise review

Umbreit, Jay N.

doi:10.1002/ajh.20249

Cited by 187 publications

(136 citation statements)

References 65 publications

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“…As a high level of extracellular free iron is deleterious, the exported iron needs to be expeditiously chelated from the vicinity of the cell (Hentze et al, 2004). One of the most abundant and high-affinity chelators of iron in serum capable of this task is apotransferrin (Sheftel et al, 2012), and the existence of an independent apotransferrin receptor for such a purpose has been suggested previously (Umbreit, 2005). We examined apotransferrin binding to the surface of iron-loaded cells and observed an increase upon iron loading.…”

Section: Discussionmentioning

confidence: 99%

Moonlighting cell surface GAPDH recruits Apo Transferrin to effect iron egress from mammalian cells

Sheokand

Malhotra

Kumar

et al. 2014

Journal of Cell Science

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Section: Discussionmentioning

confidence: 99%

Moonlighting cell surface GAPDH recruits Apo Transferrin to effect iron egress from mammalian cells

Sheokand

Malhotra

Kumar

et al. 2014

Journal of Cell Science

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“…It has increased solubility and availability at the pH of duodenum and jejunum. When given on an empty stomach, side effects like epigastric pain, nausea, vomiting and diarrhea may occur, which are relieved to a certain extent when administered after meals (Umbriet, 2005). Carbonyl iron is small particle preparation of highly purified metallic iron.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of serum ferritin levels after oral supplementation with ferrous sulphate and carbonyl iron in mild iron deficiency anemia in pregnancy

Chandrika¹,

Vasudha²

2010

International Journal of Biological and Chemical Sciences

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Iron supplementation is almost universally recommended during pregnancy to correct or prevent iron deficiency. Iron status can be assessed prepartum by estimating blood hemoglobin concentration, serum iron, serum total iron binding capacity (TIBC) and serum ferritin. This study attempts to know the therapeutic efficacy of the drugs, ferrous sulphate and carbonyl iron, in improving the iron stores to meet the increased demand during pregnancy. A comparative study was done in two groups of 36 pregnant women each. One group was supplemented with ferrous sulphate and the other group with carbonyl iron. The biochemical parameters assessing iron status, serum ferritin, serum iron and serum TIBC along with hemoglobin concentration were estimated before and after supplementation in both groups. Though not statistically significant, an increase was seen in the mean levels of serum ferritin in pregnant women who were supplemented with carbonyl iron compared to those who were supplemented with ferrous sulphate. Therefore, carbonyl iron can be preferred over ferrous sulphate in treating iron deficiency anemia in pregnancy, with added advantages of lesser side effects and shorter duration of therapy, which has been established in earlier studies.

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“…An increase of 2 g/dl in the hemoglobin level is considered to be an adequate response to oral supplementation [34]. Oral Iron Therapy should be continued for 2-3 months after anemia resolution in order to restore the body's iron stores [45]. Once IDA resolves, it is recommended to perform a 3 monthly evaluation of Hb and red cell indices for one year, then after a further year and again if symptoms of anemia develop after that [32].…”

Section: Non-transfusion Therapy Of Iron Deficiency Anemiamentioning

confidence: 99%

Are Blood Transfusions Useful for Non-Specific Symptoms of Anemia in the Elderly?

Raza¹,

Wei²,

Abid³

et al. 2014

MEDJ

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Abstract:Background: Over 10% of adults older than 65 years have World Health Organization defined anemia (Hemoglobin lower than13 g/dl in men and 12 g/dl in women). It is more prevalent with increasing age, exceeding 20% in the very elderly (85 years and older). Typical symptoms of anemia are nonspecific and often attributed to aging or to an exacerbation of another illness in the elderly. Methods:We present a case series of patients between ages 65-99 years who were followed at the Senior Health clinic and presented with nonspecific symptoms. All these patients were found to have life-threatening anemia requiring blood transfusions.Design: Case series.Results: All our elderly patients experienced good outcomes in terms of resolution of their symptoms and improvement in functional status. There was a significant difference in the total number of symptoms pre-transfusion compared with symptoms post-transfusion (p < 0.01). There were no adverse outcomes. Conclusion:Our case series suggests that symptoms of anemia in the elderly are often attributed to aging or other disease co-morbidities. Nonspecific symptoms like dyspnea, fatigue and confusion should not be ignored. Management decisions regarding anemia should involve functional assessment of the elderly subject. Immediate arrangements for transfusion must be made if the elderly patient is symptomatic regardless of the hemoglobin level. If monitored appropriately, blood transfusions can prolong survival, improve quality of life and functional status of the older individual.

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Iron deficiency: A concise review

Cited by 187 publications

References 65 publications

Moonlighting cell surface GAPDH recruits Apo Transferrin to effect iron egress from mammalian cells

Moonlighting cell surface GAPDH recruits Apo Transferrin to effect iron egress from mammalian cells

Comparative study of serum ferritin levels after oral supplementation with ferrous sulphate and carbonyl iron in mild iron deficiency anemia in pregnancy

Are Blood Transfusions Useful for Non-Specific Symptoms of Anemia in the Elderly?

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