Low-frequency ultrasound for drug delivery in the gastrointestinal tract

Reactive oxygen species responsive nanoplatforms as smart drug delivery systems for gastrointestinal tract targeting

“…Moreover, low‐frequency ultrasound is being investigated to improve drug penetration in the colonic mucosa . Drug delivery to the colonic mucosa requires that the carrier diffuses through the mucus and enter the mucosal tissue via the epithelial enhanced permeability and retention effect .…”

Convergence for Translation: Drug‐Delivery Research in Multidisciplinary Teams

“…[33] It manifests in inflammation of the GI tract leading to severe abdominal pain, urgency, and the need for frequent bowel movements.Despite the impact and severity of disease,there remains asignificant need for novel therapies.M aximizing rapid uptake locally at the sites of inflammation, and potentially enabling the topical use of biologics or antisense therapies,could greatly increase treatment options for patients suffering from IBD. [34] We identified low-frequencyu ltrasound as ap hysical mode of delivery which could be amenable to ab road range of form factors compatible with different GI compartments, enabling ultra-rapid delivery locally in the GI tract (Figure 4).…”

Translation durch Konvergenz: Drug‐Delivery‐Forschung in multidisziplinären Teams

“…Trotz der Auswirkungen und Schwere dieser Krankheit gibt es einen erheblichen Bedarf an neuartigen Therapien. Eine Maximierung der schnellen Wirkstoffaufnahme lokal an den Entzündungsorten und die potenzielle topische Anwendung von Biologika oder Antisense‐Therapien könnten die Behandlungsmöglichkeiten für IBD‐Patienten stark verbessern …”