Convergence for Translation: Drug‐Delivery Research in Multidisciplinary Teams

Traverso, Giovanni; Kirtane, Ameya R.; Schoellhammer, Carl M.; Langer, Robert

doi:10.1002/anie.201712512

Cited by 8 publications

(3 citation statements)

References 41 publications

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“…While there are numerous methodologies for targeting of any therapeutic agent to a particular tumor, [9–11] inhibiting its reactivity until it reaches the targeted region is still a considerable challenge [12] . This is much more of an issue for highly reactive singlet oxygen species, which also has a very short half‐life [13, 14] .…”

Section: Figurementioning

confidence: 99%

Targeted Singlet Oxygen Delivery: A Bioorthogonal Metabolic Shunt Linking Hypoxia to Fast Singlet Oxygen Release

Wang

et al. 2022

Angewandte Chemie

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Singlet oxygen can be generated by thermal cycloreversion of aromatic endoperoxides. However, for any practical potential of chemically generated singlet oxygen within a therapeutic context, the time and place of the release of this cytotoxic species must be tightly regulated. We now show that using a bimodular design with a hypoxia responsive unit and fluoride‐triggered endoperoxide unit, a bioorthogonal metabolic shunt can be established, where an enzymatically generated submicromolar fluoride signal plays a crucial role. Thus, cellular nitroreductase is repurposed in a bioorthogonal enzymatic activity, where it releases fluoride ions upon the reduction of a targeted compound. The fluoride ions released in the initial reaction remove the silyl stopper, yielding a highly accelerated release of singlet oxygen. The result is a remarkable difference in cytotoxicity between hypoxic and normoxic conditions as evidenced by microscopy, viability assays and the use of control compounds.

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Section: Figurementioning

confidence: 99%

Targeted Singlet Oxygen Delivery: A Bioorthogonal Metabolic Shunt Linking Hypoxia to Fast Singlet Oxygen Release

Wang

et al. 2022

Angewandte Chemie

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“…It may be that improving the effectiveness of PEs requires engineering technologies that co-localize the active and PE at the target epithelium. A focus on the final formulation requires convergence between formulation science, delivery science and engineering [51]. As academic research shifts from PEs towards nanoparticles and devices, there is less emphasis on addressing these hurdles to translation.…”

Section: An Outlook On Pes In the Delivery Fieldmentioning

confidence: 99%

Transmucosal Absorption Enhancers in the Drug Delivery Field

Maher

Casettari

Illum³

2019

Pharmaceutics

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Drug delivery systems that safely and consistently improve transport of poorly absorbed compounds across epithelial barriers are highly sought within the drug delivery field. The use of chemical permeation enhancers is one of the simplest and widely tested approaches to improve transmucosal permeability via oral, nasal, buccal, ocular and pulmonary routes. To date, only a small number of permeation enhancers have progressed to clinical trials, and only one product that includes a permeation enhancer has reached the pharmaceutical market. This editorial is an introduction to the special issue entitled Transmucosal Absorption Enhancers in the Drug Delivery Field (https://www.mdpi.com/journal/pharmaceutics/special_issues/transmucosal_absorption_enhancers). The guest editors outline the scope of the issue, reflect on the results and the conclusions of the 19 articles published in the issue and provide an outlook on the use of permeation enhancers in the drug delivery field.

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“…The challenges of controlling the flow of molecular information are well recognized [54], and considerable research aims to develop material systems that provide porosity [55], promote vascularization [56], target/control release [57][58][59][60][61][62][63][64] and allow control of motion, either autonomously [65] or externally controlled [66]. Given the importance of controlling the flow of molecular information in biology, we anticipate that there will remain great interest in creating structures to control the speed and directionality of molecular transport [2,67,68].…”

Section: Introduction: a Roadmap For Biofabrication?mentioning

confidence: 99%

Electrobiofabrication: electrically based fabrication with biologically derived materials

Kim

et al. 2019

Biofabrication

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While conventional material fabrication methods focus on form and strength to achieve function, the fabrication of material systems for emerging life science applications will need to satisfy a more subtle set of requirements. A common goal for biofabrication is to recapitulate complex biological contexts (e.g. tissue) for applications that range from animal-on-a-chip to regenerative medicine. In these cases, the material systems will need to: (i) present appropriate surface functionalities over a hierarchy of length scales (e.g. molecular features that enable cell adhesion and topographical features that guide differentiation); (ii) provide a suite of mechanobiological cues that promote the emergence of native-like tissue form and function; and (iii) organize structure to control cellular ingress and molecular transport, to enable the development of an interconnected cellular community that is engaged in cell signaling. And these requirements are not likely to be static but will vary over time and space, which will require capabilities of the material systems to dynamically respond, adapt, heal and reconfigure. Here, we review recent advances in the use of electrically based fabrication methods to build material systems from biological macromolecules (e.g. chitosan, alginate, collagen and silk). Electrical signals are especially convenient for fabrication because they can be controllably imposed to promote the electrophoresis, alignment, self-assembly and functionalization of macromolecules to generate

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Convergence for Translation: Drug‐Delivery Research in Multidisciplinary Teams

Cited by 8 publications

References 41 publications

Targeted Singlet Oxygen Delivery: A Bioorthogonal Metabolic Shunt Linking Hypoxia to Fast Singlet Oxygen Release

Targeted Singlet Oxygen Delivery: A Bioorthogonal Metabolic Shunt Linking Hypoxia to Fast Singlet Oxygen Release

Transmucosal Absorption Enhancers in the Drug Delivery Field

Electrobiofabrication: electrically based fabrication with biologically derived materials

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